DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and Ptprd

DIOPT Version :10

Sequence 1:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:XP_036019731.1 Gene:Ptprd / 19266 MGIID:97812 Length:1966 Species:Mus musculus


Alignment Length:1779 Identity:422/1779 - (23%)
Similarity:654/1779 - (36%) Gaps:501/1779 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 GFPEPNTT-------IPASDIGKDIK--FSRALPGTEYNFWLYYTNSTHREQLTW----TVNITT 149
            |.|:|..|       :..|:....||  .|.::.||.....|....|...:|..:    |.:..|
Mouse   159 GNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGT 223

  Fly   150 APDPPANLSV-QLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKEL 213
            ....||||.| :||..:..     ||   |:|                         :..:..|:
Mouse   224 RYSAPANLYVRELREVRRV-----PP---RFS-------------------------IPPTNHEI 255

  Fly   214 TPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRV 278
            .||||..:...:|                  .:|..::.|......|..  :...|.|     |.
Mouse   256 MPGGSVNITCVAV------------------GSPMPYVKWMLGAEDLTP--EDDMPIG-----RN 295

  Fly   279 SITPDDAIQSVLY----VEREGEPPGPAQAAFKGL--VPGREYNISVQTVSEDETSSVPTTARYL 337
            .:..:|..||..|    :...|.....||...|.|  .||      ...|:|...:|:       
Mouse   296 VLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPG------TPVVTESTATSI------- 347

  Fly   338 TVPERVLNVTFDEAYTTSSSFRVRWEPPRT----YSEFDAYQVMLSTSRRIFNVPRAANGDSVYF 398
                   .:|:|.......|:.:....|:.    |.|.|.    ::|:|  ::|.    |.|.|.
Mouse   348 -------TLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDG----IATTR--YSVA----GLSPYS 395

  Fly   399 DYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLR---------PRPV--RSLGGFLDDRSNALH 452
            ||        .:.||.   .:|:...|||..|..:         ||.|  |.|.      |..:.
Mouse   396 DY--------EFRVVA---VNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLS------STTIL 443

  Fly   453 ISW-EPAE-TGRQDSYRISY-------------HEQTNASEVPAPFPVAAESQITTNLTEYTLDS 502
            :.| ||.| .|:...||:.|             |.             .|:||||      |:.:
Mouse   444 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN-------------VADSQIT------TIGN 489

  Fly   503 LLAGRRYLIAVQAL-SKGVASNASDITRYTR---PAAPL-IQELRSIDQGLMLSW---RSDVNSR 559
            |:..:.|.:.|.|. |.|....:|||...|:   |..|| .:.....:..::|||   |||..: 
Mouse   490 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIA- 553

  Fly   560 QDRYEVHYQRNGTREERTMATNE--TSLTIHYLHPGSGYEVKVHAIS-------------HGVRS 609
              .||:.| |:|.:.|....|.|  ||..:..|.|.|.|..::.|.|             ..::|
Mouse   554 --SYELVY-RDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQS 615

  Fly   610 EPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAP----EGSDFSEYVVRYRT----DASPWQRIS 666
            :|.:        |||:::..:..:..:::.||.|    :....:||.::|..    |..| ..|.
Mouse   616 KPSA--------PPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSLKYAAVDGEDFKP-HEIL 671

  Fly   667 GLHENEAR--IKDMHYGERYLVQVNTVSFGVESPHPLELNVTM---------PPQPVSNVVPLVD 720
            |:..:..:  ::.:.....|.:.| |....| .|.|..|:|.:         ||:.|.  |..|:
Mouse   672 GIPSDTTKYLLEQLEKWTEYRITV-TAHTDV-GPGPESLSVLIRTDEDVPSGPPRKVE--VEAVN 732

  Fly   721 SRNLTLEWPRP-----DGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIED------- 773
            :..:.:.|..|     .|.:..|.:.:   .:.:..|.|....|:|:.....:...:|       
Mouse   733 ATAVKVSWRSPVPNKQHGQIRGYQVHY---VKMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI 794

  Fly   774 ---LSPGRQYRFEVQA---SSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPT 832
               |.|...|...|.|   ..:|.||....:|| |..:......:.|    ..|..|..:.:.| 
Mouse   795 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVST-TGAVPGKPRLVIN----HTQMNTALIQWHP- 853

  Fly   833 PADS-TRFDIYRFSMGDPTIKDKEKLA----NDTERKLSFSGLTPGKLYNVTVWTVSG----GVA 888
            |.|: .....||...|.   ||.|.|.    ::.|...:.:.:..|..|   |:.:|.    |..
Mouse   854 PVDTFGPLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATDIHKGASY---VFRLSARNKVGFG 912

  Fly   889 SLPVQRLYRLHPLPI---SDLKAIQVAAREITLHWTAPA-----GEYTDFELQYLSADEEAPQLL 945
            ...|:.:.....:|.   .:|.:....:..:.|.|..|.     |..|.:.|.|  .|...|.|.
Mouse   913 EEMVKEISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGVITKYTLLY--RDINVPLLP 975

  Fly   946 QN---VTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPP 1007
            ..   |..:|.:||.||:  .:.|:.|.||:.:.:|              ..|.|.|.|..|.|.
Mouse   976 MEHLIVPADTSMTLTGLK--SDTTYDVKVRAHTSKG--------------PGPYSPSVQFRTLPV 1024

  Fly  1008 GKVDY---FQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKID 1069
            .:..:   |....|....|...|  |..|.:.....|:|.   .||...|.  |....|||..|.
Mouse  1025 DQAVFAKNFHVKAVMKTSVLLSW--EIPENYNSAMPFKIL---YDDGKMVE--EVDGRATQKLIV 1082

  Fly  1070 GLVPGNHYIF--------------RIQAKSALGYGAEREHIQTMP-------------ILAPPVP 1107
            .|.|...|.|              |:.||:|      .:.::|.|             :..|.||
Mouse  1083 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA------PDVLRTKPAFIGKTNLDGMITVQLPDVP 1141

  Fly  1108 EPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWL 1172
                                       |:..::.|.|||..  .|.:.|..:..|:......:  
Mouse  1142 ---------------------------ANENIKGYYIIIVP--LKKSRGKFIKPWESPDEMEL-- 1175

  Fly  1173 PYQAIEPYNPFLTSNGSRKSSLE-----------AEHF----TIGTANCDKHQAGYCNGPLRAGT 1222
                    :..|.....::.|:.           |.||    |..|...|||..|:.|..|::|.
Mouse  1176 --------DELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQ 1232

  Fly  1223 TYRIKIRAFTD--EDK------FTDTVYS-----SPITTERSDTVIVAATVSAVLLVAMVLVVVY 1274
            .|...:.|..|  |.|      ::|.|.|     .|||.|....:.|...|.||:.:..:::.: 
Mouse  1233 EYVFFVLAVMDHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI- 1296

  Fly  1275 CQHRCQLIRRAS----KLARMQDELAALPEGYITPNR---------------------------- 1307
                  |:.::|    |.|..:...::||.....|:.                            
Mouse  1297 ------LLYKSSKPDRKRAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPALSSNSVPYASL 1355

  Fly  1308 ----------------------------------PVHVKDFSEHYRIMSADSDFRFSEEFEELKH 1338
                                              |:.:.:.::|...:.|:.:.:||:|:|.: .
Mouse  1356 IGSVSSLSSQTTTQSIYDNNSLPRFARKGMASHPPIPILELADHIERLKANDNLKFSQEYESI-D 1419

  Fly  1339 VGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQG 1403
            .|:......:||..|:||||:.|::.|||||..|..::...||||:||||:.|:.....:|.|||
Mouse  1420 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG 1484

  Fly  1404 PLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWS 1468
            .|..|..:||||.||..|..:||:|:..|:.|.||||||| .|....:|.::|.|:.......:.
Mouse  1485 SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYC 1548

  Fly  1469 ISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGR 1531
            :..|.:.:|  .|.|.:|.|.||.|||.||||.|...:.|:|..:.....|..|::|||||||||
Mouse  1549 VRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGR 1613

  Fly  1532 SGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSL 1596
            :|.||.:|.:|:.|.....|||:|.|..||.:|.:|||||.||:.||..||      |.:...:.
Mouse  1614 TGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL------EAVTCGNT 1672

  Fly  1597 ELHANDGYEVTKIYLERQPQTKMG 1620
            |:.|.:.|    .|:::..|.:.|
Mouse  1673 EVPARNLY----AYIQKLTQIETG 1692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628 52/255 (20%)
fn3 247..328 CDD:394996 19/86 (22%)
FN3 319..>749 CDD:442628 113/506 (22%)
fn3 708..796 CDD:394996 22/105 (21%)
fn3 902..978 CDD:394996 22/86 (26%)
fn3 1013..1092 CDD:394996 24/92 (26%)
PTP_tm 1127..1247 CDD:465889 31/147 (21%)
R3-PTPc 1358..1579 CDD:350396 97/222 (44%)
PtprdXP_036019731.1 I-set 31..123 CDD:400151
Ig strand B 48..52 CDD:409390
Ig strand C 61..65 CDD:409390
Ig strand E 85..92 CDD:409390
Ig strand F 103..108 CDD:409390
Ig strand G 116..119 CDD:409390
IgI_2_RPTP_IIa_LAR_like 135..234 CDD:409400 19/74 (26%)
Ig strand A 135..137 CDD:409400
Ig strand A' 142..146 CDD:409400
Ig strand B 149..158 CDD:409400
Ig strand C 163..169 CDD:409400 2/5 (40%)
Ig strand C' 171..173 CDD:409400 0/1 (0%)
Ig strand D 182..186 CDD:409400 2/3 (67%)
Ig strand E 198..203 CDD:409400 1/4 (25%)
Ig strand F 212..219 CDD:409400 0/6 (0%)
Ig strand G 222..233 CDD:409400 5/10 (50%)
IgI_3_RPTP_IIa_LAR_like 247..328 CDD:409401 20/130 (15%)
Ig strand A 247..249 CDD:409401 1/26 (4%)
Ig strand A' 253..257 CDD:409401 1/3 (33%)
Ig strand B 260..268 CDD:409401 1/7 (14%)
Ig strand C 273..279 CDD:409401 1/5 (20%)
Ig strand C' 281..283 CDD:409401 0/1 (0%)
Ig strand D 286..290 CDD:409401 0/5 (0%)
Ig strand E 295..300 CDD:409401 0/4 (0%)
Ig strand F 307..314 CDD:409401 1/6 (17%)
FN3 312..>744 CDD:442628 117/514 (23%)
Ig strand G 318..327 CDD:409401 2/8 (25%)
fn3 721..820 CDD:394996 20/103 (19%)
FN3 <797..1135 CDD:442628 86/380 (23%)
FN3 930..1021 CDD:238020 26/108 (24%)
R-PTPc-D-1 1388..1671 CDD:350472 115/290 (40%)
R-PTP-D-2 1672..1963 CDD:350476 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

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