DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and Ptpn13

DIOPT Version :10

Sequence 1:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_035334.2 Gene:Ptpn13 / 19249 MGIID:103293 Length:2451 Species:Mus musculus


Alignment Length:1981 Identity:408/1981 - (20%)
Similarity:630/1981 - (31%) Gaps:703/1981 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 QQLQKQRHNHHHYYQNSQQQQKHFVWLVVGILT---IFLAQHANAADLVINVPNASSNANAFYRI 91
            |:|.:...:.|..:...:.|    ..:::|:.:   :....|.....||:..|...:...:|.: 
Mouse   764 QRLTEYGVHFHRVHPEKKSQ----TGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISFSK- 823

  Fly    92 DYSPPFGFPEPNTTIPASDIGKDIKFSRALPGTEYNF----------WLYYTNSTHREQLTWTV- 145
                                 |.|.......|.::.|          .|:..:|.|:.||.... 
Mouse   824 ---------------------KKITLQNTSDGIKHAFQTDSSKACQYLLHLCSSQHKFQLQMRAR 867

  Fly   146 -------NITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLP-----FERSY 198
                   :|..|.....||..:   |...|...|...:|..:...|..|.:..|.     .:|..
Mouse   868 QSNQDAQDIERASFRSLNLQAE---SVRGFNMGRAISTGSLASSTINKLAVRPLSVQAEILKRLS 929

  Fly   199 SLEGN--ETLQLSAKELTPGGSYQ-------------------------------VQAYSVYQGK 230
            |.|.:  :.||.|:||.|...|::                               .||::...||
Mouse   930 SSEWSLYQPLQNSSKEKTDKASWEEKPRGMSKSYHDLSQASLCPHRKQVINMEALPQAFAELVGK 994

  Fly   231 ----------------------ESVAYTS-----RNFTTKPNT--PGK-FIVWFRNETTLLVLWQ 265
                                  :|||..:     ||..:..:|  ||: ::|.....::.....|
Mouse   995 PLYPMARSDTESLAGLPKLDNSKSVASLNRSPERRNHESDSSTEDPGQAYVVGMSLPSSGKSSSQ 1059

  Fly   266 PPFPAGIYTHYRVSI--TPDDAIQ--------------SVLYVEREGE-----------PPGPAQ 303
            .||......|.|.||  :|:..|.              .::..|:.|.           |.|||.
Mouse  1060 VPFKDNDTLHKRWSIVSSPEREITLVNLKKDPKHGLGFQIIGGEKMGRLDLGVFISAVTPGGPAD 1124

  Fly   304 AAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTY 368
              ..|.:...:..|||.:||.:..|...........||.|..|........|       :.|.|.
Mouse  1125 --LDGCLKPGDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPS-------KVPSTP 1180

  Fly   369 SEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYP-----DILEPGRTYEVVVKTIADNVNSWPASG 428
            ..|                   |||...|...|     ..::|...            ..||.. 
Mouse  1181 VHF-------------------ANGMKSYTKKPAYMQDSAMDPSED------------QPWPRG- 1213

  Fly   429 EVTLR--PRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTN---ASEV--------- 479
              |||  |.....|.|.|.:.|.:       ::..|.:|..:| ..|.|   ||.:         
Mouse  1214 --TLRHIPESPFGLSGGLREGSLS-------SQDSRTESASLS-QSQVNGFFASHLGDRGWQEPQ 1268

  Fly   480 ---PAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQEL 541
               |:|       .:||.:.|.|...                   ||.|...|  |..:.||:.|
Mouse  1269 HSSPSP-------SVTTKVNEKTFSD-------------------SNRSKAKR--RGISDLIEHL 1305

  Fly   542 RSIDQGLMLSWRSD--VNSRQDRYEVHYQRNGTREERTMAT-NETSLTIHYL---HPGSGYEVKV 600
            ...|     |.:.|  ..|.||     :|.:......:::| |:||......   .||..:||::
Mouse  1306 DCAD-----SDKDDSTYTSSQD-----HQTSKQEPSSSLSTSNKTSFPTSSASPPKPGDTFEVEL 1360

  Fly   601 H--------AISHGVR-SEPHS--YFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVR 654
            .        :::.||. |..|.  |.:|:.||                                 
Mouse  1361 AKTDGSLGISVTGGVNTSVRHGGIYVKAIIPK--------------------------------- 1392

  Fly   655 YRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSF-------------------------- 693
                        |..|::.||   |.|:|.|. ||.||.                          
Mouse  1393 ------------GAAESDGRI---HKGDRVLA-VNGVSLEGATHKQAVETLRNTGQVVHLLLEKG 1441

  Fly   694 -----------GVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDE 747
                       |.:||.|.:......|:.|:...|                ||..|:.    ..|
Mouse  1442 QVPTSRERDPAGPQSPPPDQDAQRQAPEKVAKQTP----------------HVKDYSF----VTE 1486

  Fly   748 EDRVE---FKNVTQL------------EDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTH 797
            ::..|   |||.:.|            |.::...||  ::.|.||     :..|.|..|..|...
Mouse  1487 DNTFEVKLFKNSSGLGFSFSREDNLIPEQINGSIVR--VKKLFPG-----QPAAESGKIDVGDVI 1544

  Fly   798 LSTRTMP---LIQSDVFIANAGHEQ--------------GQDETITLSYTPTPADSTRFDIYRFS 845
            |.....|   |.|.||..|..|...              .:.:|..|:...:||:|........|
Mouse  1545 LKVNGAPLKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEIDTTFLNPLYSPANSFLNSSKETS 1609

  Fly   846 MGDPTIKD----------------------KEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVA 888
            ....:::.                      :|..::.:|.....|...|.|:.|||      .||
Mouse  1610 QPSSSVEQGASSDDNGVSGKTKNHCRAPSRRESYSDHSESGEDDSVRAPAKMPNVT------RVA 1668

  Fly   889 SLP----------VQRLYRL-------------HPLPISDLKAIQV-------AAREIT-LHWTA 922
            :.|          :..::.|             ||.|: |:...|.       |..:.| .|:|.
Mouse  1669 AFPHEAPRSQEESICAMFYLPRKIPGKLESESSHPPPL-DVSPGQTCQPPAECAPSDATGKHFTH 1732

  Fly   923 PAGEYTDFEL---------QYLSADEEAPQLLQNVTKNTEITL-----QGLRPYHNYTFTVV--- 970
            .|.:.:..|.         .:|...|...:||..:.|:.:.:|     :|.:....|...|:   
Mouse  1733 LASQLSKEENITTLKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDP 1797

  Fly   971 -VRSGSIQGTD----FADVSVSTLMRSSAP--ISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWS 1028
             ...|.::..|    ..|..|:.:..:.|.  :.|:.:|:....|::              .|..
Mouse  1798 AKGDGRLKAGDRLIKVNDTDVTNMTHTDAVNLLRAAPKTVRLVLGRI--------------LELP 1848

  Fly  1029 LEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAER 1093
            ..|...|...| ..:||...:       ..|.::..||...|:|    ||..|..:||   .|..
Mouse  1849 RMPVFPHLLPD-ITVTCHGEE-------LGFSLSGGQGSPHGVV----YISDINPRSA---AAVD 1898

  Fly  1094 EHIQTMPIL------------------APPVPEPSVTPLEVSRTSSTIEISFRQGY----FSNAH 1136
            ..:|.:.|:                  |..:..|||. |:|:|....:..:.|...    |:.|:
Mouse  1899 GSLQLLDIIHYVNGVSTQGMTLEDANRALDLSLPSVV-LKVTRDGCPVVPTTRAAISAPRFTKAN 1962

  Fly  1137 GMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTI 1201
            |:                :.:| ||.|           .|:.|.|.|...||      |..|..:
Mouse  1963 GL----------------TSME-PSGQ-----------PALMPKNSFSKVNG------EGVHEAV 1993

  Fly  1202 GTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFT----DTVYSSPITTERSDTVIVAATVSA 1262
                        |  |...|::.::|..|...|.|.:    |.:|..|...|...:::......|
Mouse  1994 ------------C--PAGEGSSSQMKESAGLTETKESNSRDDDIYDDPQEAEVIQSLLDVVDEEA 2044

  Fly  1263 VLL-------------------------------------------------VAMVLVVVYCQHR 1278
            ..|                                                 |.:..:....|..
Mouse  2045 QNLLNQRHATRRACSPDPLRTNGEAPEEGDTDYDGSPLPEDVPESVSSGEGKVDLASLTAASQEE 2109

  Fly  1279 CQLIRRASKLAR-------------------MQDELAALPEGYITPNRPVHVKDFSEHYRIMSAD 1324
            ..:...|::.:|                   ..:||||||...:.|:............|.:...
Mouse  2110 KPIEEDATQESRNSTTETTDGEDSSKDPPFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGL 2174

  Fly  1325 SDFRF-SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANY 1388
            .|... |:|.|.|:.:.....|.......||.|||:.||||||.:|.   |:.|:.|  ||||::
Mouse  2175 LDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRV---PLGDEGG--YINASF 2234

  Fly  1389 MPGHNSPREF--IVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP--VDRVAM 1449
            :......:||  |..||||.:|..:||:|.||.||..|.|:|:..|..:.||.:|||  :....|
Mouse  2235 IRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTM 2299

  Fly  1450 FYGDIKVQLIIDTHYHDWSISEFMVS-------RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFV 1507
            ....:::.|:     ....:..|:|.       :..|.|.:.|.:||.|||...|..|..|:.|:
Mouse  2300 ANERLRLALL-----RMQQLKGFIVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSQPDDLLTFI 2359

  Fly  1508 RAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQ 1572
            ...|.:..:.  |:|.|||||:|||||.|.:|.:|..|.:....||..:|..||.:|..|||||.
Mouse  2360 SYMRHIRRSG--PVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEG 2422

  Fly  1573 QYVCIHQCLLAVLEGKEHLLADSLELHANDG 1603
            |||..:|.:|.||   .||.|:  |..|..|
Mouse  2423 QYVFCYQVILYVL---THLQAE--EQKAQPG 2448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628 65/352 (18%)
fn3 247..328 CDD:394996 24/108 (22%)
FN3 319..>749 CDD:442628 95/505 (19%)
fn3 708..796 CDD:394996 22/102 (22%)
fn3 902..978 CDD:394996 19/101 (19%)
fn3 1013..1092 CDD:394996 16/78 (21%)
PTP_tm 1127..1247 CDD:465889 26/127 (20%)
R3-PTPc 1358..1579 CDD:350396 86/231 (37%)
Ptpn13NP_035334.2 KIND 3..190 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..227
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..457
FERM_F1_PTPN13 564..659 CDD:340715
B41 566..774 CDD:214604 2/9 (22%)
PH-like 770..870 CDD:473070 17/125 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..966 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1063 11/55 (20%)
PDZ1_PTPN13-like 1081..1172 CDD:467285 18/92 (20%)
PTN13_u3 1168..1356 CDD:465189 54/274 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1199..1356 45/217 (21%)
PDZ2-PTPN13_FRMPD2-like 1354..1440 CDD:467254 22/134 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1478 7/52 (13%)
PDZ3_PTPN13_FRMPD2-like 1489..1578 CDD:467181 23/95 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1602..1662 6/59 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1695..1726 6/31 (19%)
PDZ4_PTPN13-like 1760..1844 CDD:467182 15/83 (18%)
PDZ5_PTPN13-like 1855..1941 CDD:467183 23/101 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2024 8/46 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2051..2139 4/87 (5%)
PTPc-N13 2202..2435 CDD:350445 92/244 (38%)
Blue background indicates that the domain is not in the aligned region.

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