Protein Alignment Ptp4E and Ptprh

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001416083.1
• Gene: Ptprh / 171125
• RGDID: 620553
• Length: 1286
• Species: Rattus norvegicus
• Alignment Length: 1504
• Identity: 378/1504 - (25%)
• Similarity: 585/1504 - (38%)
• Gaps: 348/1504 - (23%)

  Fly   148 TTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLE-----GNETLQ 207
            |.||:|..||..:.:::.|..:.|..|..             || |...:|.::     |:...|
  Rat    27 TAAPNPVINLRTETQTNTSITLRWEVPDG-------------TD-PQNLTYWIQWLRDGGSNNTQ 77

  Fly   208 L------SAKELTPGGSYQVQAYSVYQGKESVAYTSRNF--TTKPNTPGKFIVWFRNETTLLVLW 264
            :      :...|.|..||:   :||:..|:.|:.:.:..  ||..|......|..:|.|.:.:.|
  Rat    78 ITTGTRVTVDRLAPASSYE---FSVWAEKDGVSGSPQTLIATTASNKVSNLRVEGQNTTAISLSW 139

  Fly   265 QPPFPAGIYTHYRVSITPDDAIQSVLY--------VEREGEPPGPAQAAFKGLVPGREYNISVQT 321
            .||              .:.:.|.:.|        .:.|.......:....||.||..|..||:
  Rat   140 DPP--------------ENSSSQDLTYWAQCIGYDGKNETRHTKDTRVTVDGLDPGTSYECSVR- 189

  Fly   322 VSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFN 386
            |.:|...|...|....|...:|.|:..:...||:.|  :.|:||...|..|.............|
  Rat   190 VEKDGVYSTWETKNTTTASNKVSNLRVEGQNTTAIS--LSWDPPENSSSQDLTYWAQCIGYDGQN 252

  Fly   387 VPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSL---GGFLDDRS 448
            ..|......|..|.   |:||.:||..|:...|.|.|...:...|..|.|||:|   |    ..:
  Rat   253 ETRHTKDTRVTVDG---LDPGTSYECSVRVEKDGVYSTWETKNTTTAPNPVRNLRVEG----QNT 310

  Fly   449 NALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAV 513
            .|:.:||:|.|.
  Rat   311 TAISLSWDPPEN----------------------------------------------------- 322

  Fly   514 QALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTM 578
                    |::.|:|                      .|...:.     |:   .:|.||.
  Rat   323 --------SSSQDLT----------------------YWAQCIG-----YD---GKNETRH---- 345

  Fly   579 ATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAP 643
             |.:|.:|:..|.||:.||..|.....||.|...:......|.|.:||.::..:|..:.|.|..|
  Rat   346 -TKDTRVTVDGLDPGTSYECSVRVEKDGVYSTWETKNTTTAPNPVRNLRVEGQNTTSISLSWDPP 409

  Fly   644 EGS---DFSEYVVRYRTDASPWQRISGLHENEARIK--DMHYGERYLVQVNTVSFGVESPHPLEL 703
            |.|   |.:.:....|.|.....|    |..:.|:.  .:..|..|...|.....||.|....:
  Rat   410 ENSSSQDLTYWAQCIRYDGQNETR----HTKDTRVSVDGLDPGTSYECSVRVEKDGVYSTWETK- 469

  Fly   704 NVTMPPQPVSNVVPLVDSRNLT---LEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSP 765
            |.|..|.||.|:  .|:.:|.|   |.|..|: :.....|.:|.  :..|.:.:|.|:    .:.
  Rat   470 NTTTAPNPVRNL--RVEGQNTTSISLSWDPPE-NSSSQDLTYWA--QCIRYDGQNETR----HTK 525

  Fly   766 SVRIPIEDLSPGRQYRFEVQASSNGIRS--GTTHLSTRTMPLIQSDVFIANAGHEQGQDET-ITL 827
            ..|:.::.|.||..|...|:...:|:.|  .|.:.:|.:.|:....|        :||:.| |:|
  Rat   526 DTRVTVDGLDPGTSYECSVRVEKDGVYSTWETKNTTTASNPVRNLTV--------EGQNTTAISL 582

  Fly   828 SYTPTPADSTRFDIYRFSM-----GDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGV 887
            |:.| |.:|:..|:..::.     |    |::.:...||  :::..||.||..|..:|.....||
  Rat   583 SWDP-PENSSSQDLTYWAQCIGYDG----KNETRHTKDT--RVTVDGLDPGTSYECSVRVEKDGV 640

  Fly   888 ASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNV---- 948
            .|....:.....|.|:.:|:........|:|.|..|..          |:.::.....|.:
  Rat   641 YSTWETKNTTTAPNPVRNLRVEGQNTTAISLSWDPPEN----------SSSQDLTYWAQCIGYDG 695

  Fly   949 ------TKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQT--LTA 1005
                  ||:|.:|:.||.|..:|..:|.|....:..|                    ::|  .|.
  Rat   696 KNETRHTKDTRVTVDGLDPGTSYECSVRVEKDGVYST--------------------WETKNTTT 740

  Fly  1006 PPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDY-FRITCQNADDAADVSSYEFPVNATQGKID 1069
            .|..|...:........::..|  :|.|.....|. :...|...|...:...    ...|:..:|
  Rat   741 APNPVRNLRVEGQNTTSISLSW--DPPENSSSQDLTYWAQCIRYDGQNETRH----TKDTRVSVD 799

  Fly  1070 GLVPGNHYIFRIQAKSALGYGA-EREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGY-- 1131
            ||.||..|...::.:....|.. |.::..|:             |..|:.||.   ||...||
  Rat   800 GLDPGTSYECSVRVEKDGVYSTWETKNTTTV-------------PAAVNITSC---ISTSGGYGI 848

  Fly  1132 ---FSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSS 1193
               :|...|...::.:    :||:        .|.                     :.|||.
  Rat   849 ILTWSCPSGSYETFEV----EVGR--------KWS---------------------SQNGSL--- 877

  Fly  1194 LEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAA 1258
                        |.|   |.....|....:|...:...::..|    |.|:|.|.....|.::|.
  Rat   878 ------------CGK---GMTVLDLEPAQSYTATVTTVSNSLK----VQSAPATCRTESTAVIAG 923

  Fly  1259 TVSAVLLVAMV--LVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIM 1321
            .:..:||:.::  |::|:.:.|    |:..:...:..:|.....|.|.      .|||::|.|..
  Rat   924 AIVGILLLFILVGLLIVFLKRR----RKKQQPKEVPKDLVFRFPGDIL------AKDFADHVREN 978

  Fly  1322 SADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINA 1386
            ..||:..|:||:::|...|:.|:...|....|..|||:.|:||||.||..|||:.::.|||||||
  Rat   979 EKDSNCGFAEEYQQLALEGQGQSQMTALALENVSKNRYRNVLPYDWSRVPLQPLHEEPGSDYINA 1043

  Fly  1387 NYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFY 1451
            ::|||..||:|||.|||||..|..:||||.||..|..:|||..|.|.|:.||:.|||:|.....:
  Rat  1044 SFMPGLWSPKEFIATQGPLPHTVSDFWRMVWEQQSHTLVMLANCMESGQVKCEHYWPLDAQPCTH 1108

  Fly  1452 GDIKVQLIIDTHYHDWSISEFMVSRNCESRIM--RHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI 1514
            |.::|.|:.:....:|::....:....|.:.:  |.||:..|||.|||..|..|:.|.:..|..:
  Rat  1109 GQLQVTLVSEEVTENWTVRHLQLFHMKEQQTLSVRQFHYVAWPDHGVPYSPDPLLAFQKLLRQWL 1173

  Fly  1515 GTDM--RPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCI 1577
            ...|  .|.||||||||||:||.||||.:|:.:.....||.|..|..||:.|..|||||.|||.:
  Rat  1174 DQTMDGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVDPFSFVKKMRESRPLMVQTEAQYVFL 1238

  Fly  1578 HQCLLAVLE 1586
            |||:|..|:
  Rat  1239 HQCILRSLQ 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	45/206 (22%)
		fn3	247..328	CDD:394996	18/88 (20%)
		FN3	319..>749	CDD:442628	97/440 (22%)
		fn3	708..796	CDD:394996	23/92 (25%)
		fn3	902..978	CDD:394996	18/85 (21%)
		fn3	1013..1092	CDD:394996	14/80 (18%)
		PTP_tm	1127..1247	CDD:465889	19/124 (15%)
		R3-PTPc	1358..1579	CDD:350396	103/224 (46%)
Ptprh	NP_001416083.1	None