Protein Alignment Ptp4E and Ptp10D

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_061506139.1
• Gene: Ptp10D / 1274091
• VectorBaseID: AGAMI1_005906
• Length: 1864
• Species: Anopheles gambiae
• Alignment Length: 1741
• Identity: 945/1741 - (54%)
• Similarity: 1203/1741 - (69%)
• Gaps: 147/1741 - (8%)

  Fly    60 ILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALPGT 124
            ::.:.|||....|||||.:|......::|||:||.||.|.|.||.||.:.|:|.:|:||..||||
Mosquito    61 LVVLLLAQQCYGADLVIEIPGNQGLDDSFYRLDYYPPIGNPAPNATIASRDVGDEIQFSNGLPGT 125

  Fly   125 EYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGL 189
            .||||||||||||::.|||||:|||||||||||:|..||.|:..|.|.||..|.||.|::::|||
Mosquito   126 RYNFWLYYTNSTHKDWLTWTVSITTAPDPPANLTVIPRSGKNVIINWSPPAQGNYSSFKLKILGL 190

  Fly   190 TD-LPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTK---------- 243
            :| ....::.::|.|: .|...::||||.:||||||::|.|||||||||||||||
Mosquito   191 SDNFATNQTVAIEDNQ-FQYMVRDLTPGATYQVQAYTLYDGKESVAYTSRNFTTKRYRHKDLLDI 254

  Fly   244 -----PNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQ 303
                 ||||||||||||||||||||||||:||||||||:|||.|.||:.|||||::|||||||||
Mosquito   255 KILREPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDALGSVLYVQKEGEPPGPAQ 319

  Fly   304 AAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTY 368
            ||||||||||.|||||||:||||. |:||||:|.|||.|.:|||||:...|.:||:|.||.|:..
Mosquito   320 AAFKGLVPGRAYNISVQTMSEDEI-SLPTTAQYRTVPLRPMNVTFDKKSITENSFKVMWEAPKGT 383

  Fly   369 SEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLR 433
            ||||.|||.||||||...|.|..|.:..:.::.|.|:||:||:|||||::..|.||||||:|||:
Mosquito   384 SEFDKYQVSLSTSRRQQAVLRNDNENMAWLEFKDNLDPGKTYQVVVKTVSGKVTSWPASGDVTLK 448

  Fly   434 PRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHE-QTNASEVPAPFPVAAESQITTNLTE 497
            |.||:.|..:.|.::..:.|||:|.|...||.||||||| :||..:         .|.::||.|.
Mosquito   449 PLPVKQLQSYTDSKTGVITISWKPDELSTQDEYRISYHELETNNGD---------SSTMSTNQTS 504

  Fly   498 YTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDR 562
            :.|:|||.||.|.:.|||||:.:.||.:.|...|||::|:|::|:||.:||.:||:|||||:||:
Mosquito   505 FALESLLPGRNYSVTVQALSRKMESNETVIFVVTRPSSPIIEDLKSIREGLNISWKSDVNSKQDK 569

  Fly   563 YEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLT 627
            |||.|.||.|.:.:|:.|.|:.|....|:||:||||||.|:|||:|||||||||||:|.||:|:|
Mosquito   570 YEVTYTRNDTNDGKTVLTTESRLVFTNLYPGAGYEVKVFAVSHGLRSEPHSYFQAVYPNPPRNMT 634

  Fly   628 LQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDA-SPWQRISGLHENEARIKDMHYGERYLVQVNTV 691
            ::.|.:|.|::||:.||.|:|:||.:||||:: ..|.|:..:...||.:.||..||:|.:|||||
Mosquito   635 IEKVTSNSVLVHWKPPERSEFTEYSIRYRTESEKQWIRLPSVKATEADVTDMTPGEKYTIQVNTV 699

  Fly   692 SFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNV 756
            |:|||||:|.::|.|:.|.||||:.|||||.|:|||:|||:|.|:.|.:.||||::.::|..||.
Mosquito   700 SYGVESPNPQQVNQTVRPNPVSNIAPLVDSNNITLEFPRPEGRVETYIIHWWPTEQPEQVSMKNF 764

  Fly   757 TQLEDL---------------SSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLI 806
            |::..:               ..|.||:.|.||..|..|.|::|..|.|:.|..|.|.|||||||
Mosquito   765 TEVNTILPYPGTLSDDEKTVEEPPLVRLLIGDLMSGVMYNFKIQTISYGLTSDLTKLQTRTMPLI 829

  Fly   807 QSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLT 871
            ||:|.|.|..|.:   :.:||||||||..|::||:||||:|||:|.|||||||||:||::|:|||
Mosquito   830 QSEVVIVNNMHTR---DMVTLSYTPTPQQSSKFDLYRFSLGDPSIPDKEKLANDTDRKVTFTGLT 891

  Fly   872 PGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLS 936
            ||:|||:|||||||.|:|.|:||..|:.|.||:.|:|..:....|.|.|..|.||||.||:|||.
Mosquito   892 PGRLYNITVWTVSGKVSSQPIQRQDRMFPDPITMLEATSINDTWIALKWDIPKGEYTSFEVQYLM 956

  Fly   937 ADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQ 1001
            .|.   ..:||.|.|..||:..|:|:.|||.|||||||          :.|:::|.|.||||::|
Mosquito   957 NDS---HYVQNYTVNNHITITDLKPHRNYTITVVVRSG----------TESSVLRVSLPISANFQ 1008

  Fly  1002 TLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQG 1066
            |..|.||::|.|.|.|:||.|:||||||.|.||:|.|..|.|| ...|.:......:|..|..:|
Mosquito  1009 TKEALPGRMDKFAPIDIQPSEITFEWSLPPNEQNGIIRQFTIT-YGLDGSQHTQVKDFRPNELRG 1072

  Fly  1067 KIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGY 1131
            .|..|.||..|:||||||:|:|||.|....|.|||||||.||..|.|.||..:::||||.||:.|
Mosquito  1073 SIKALQPGKSYVFRIQAKTAIGYGPEHIWKQKMPILAPPKPETQVVPTEVGSSATTIEIRFRKHY 1137

  Fly  1132 FSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEA 1196
            ||:.:|:|.:||||||||..|||||||||||:|||:|:||.|||.||||.||..|:        .
Mosquito  1138 FSDQNGVVTTYTIIIAEDDSKNASGLEMPSWRDVQSYSVWPPYQVIEPYYPFKNSS--------V 1194

  Fly  1197 EHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITT-------ERSDTV 1254
            |.|||||.|||..:.|||||||::||||::|:||||..||||||.||.||.|       :.:.::
Mosquito  1195 EDFTIGTENCDAKKTGYCNGPLKSGTTYKVKVRAFTAPDKFTDTAYSYPIRTALLSVDAQDNTSL 1259

  Fly  1255 IVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYR 1319
            ||:.||..:::..:|.||::.:.|....|:.:: .|..|.: :||:..|..:|||.||:|:||||
Mosquito  1260 IVSITVPLLIIAMLVGVVLFLRRRRHTGRKTTE-QRTNDNM-SLPDSTIETSRPVLVKNFAEHYR 1322

  Fly  1320 IMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYI 1384
            :||||||||||||||||||:||||.|:||:||||||||||||||||||||||||||||::|||||
Mosquito  1323 MMSADSDFRFSEEFEELKHIGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDEEGSDYI 1387

  Fly  1385 NANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAM 1449
            ||||:||||||||||||||||||||::||||||||||||||||||.|||||||||.|||.|.|.:
Mosquito  1388 NANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRTFEKGREKCDHYWPHDTVPV 1452

  Fly  1450 FYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI 1514
            :||||||.|:.|:||.||.|:|||::|..:.||:||||||||||||||.|||:|.|||||||:.:
Mosquito  1453 YYGDIKVTLLNDSHYPDWVITEFMMTRGEQQRIIRHFHFTTWPDFGVPNPPQTLARFVRAFRERV 1517

  Fly  1515 GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQ 1579
            |.|.|||:||||||||||||||.||||||.|..||||||||||:|||||||:||||||||:||||
Mosquito  1518 GPDQRPIVVHCSAGVGRSGTFITLDRILQQIQVSDYVDIFGIVWAMRKERVWMVQTEQQYICIHQ 1582

  Fly  1580 CLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDADLMTNKDE 1644
            |||.||||||   ....|:|.|.|||                                      |
Mosquito  1583 CLLVVLEGKE---GTEREIHDNQGYE--------------------------------------E 1606

  Fly  1645 DEDQEQQQQQQLQLATEVKPKGSNDDEEDE---EDDDDDDDDQQPLNNETTATLSSASCSSSTHD 1706
            ..|.:||.::||.:      :..:|||.||   .:....:.....:.|.......||:
Mosquito  1607 PRDDDQQSEEQLLI------ENRSDDELDEVAAREQHQQNGTAGGIENHELDRRRSAT------- 1658

  Fly  1707 VHVVLQEAIEKPKQEQERICAGTQSHADTESDNTDSDDDDEDGDGKVAKDG 1757
            |.:|..|.:   ..:|....||         :.|:.:..||:.:.:|..||
Mosquito  1659 VEIVDNELV---MMQQANFTAG---------ETTEEELLDEEEEVEVTVDG 1697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	166/255 (65%)
		fn3	247..328	CDD:394996	70/80 (88%)
		FN3	319..>749	CDD:442628	227/431 (53%)
		fn3	708..796	CDD:394996	41/102 (40%)
		fn3	902..978	CDD:394996	36/75 (48%)
		fn3	1013..1092	CDD:394996	39/78 (50%)
		PTP_tm	1127..1247	CDD:465889	76/119 (64%)
		R3-PTPc	1358..1579	CDD:350396	178/220 (81%)
Ptp10D	XP_061506139.1	None