DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and ptprb

DIOPT Version :10

Sequence 1:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_001131088.2 Gene:ptprb / 100192375 XenbaseID:XB-GENE-991728 Length:2326 Species:Xenopus tropicalis


Alignment Length:1768 Identity:485/1768 - (27%)
Similarity:755/1768 - (42%) Gaps:397/1768 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 NTTIPASDIGKDIKFSRAL-PG--TEYNF------WLYYTN-STHREQLTWTVNIT--TAPDPPA 155
            |.|:  ||.| .||:||.: ||  ||..|      .||... ||...:|:.:...|  |.|:..|
 Frog   646 NVTL--SDTG-SIKYSRTVHPGTPTEITFTGLTPGHLYQVGISTIAGELSTSRMATGQTIPEKVA 707

  Fly   156 NLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKE-------L 213
            :|.......:|..::|.|| ||.:..:.|.:...|        ::..|.|:....:|       |
 Frog   708 DLKAVSNGLRSLRLSWVPP-SGDWDKYNIVLYNNT--------AVLVNTTIDKKYREYVIQDIGL 763

  Fly   214 TPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFR----NETTLLVLWQPPFPAGIYT 274
            .||..|:. ...|..||.......:..|..|     .::..|    ||::|.::|  ..|...:.
 Frog   764 IPGRQYEA-VVIVESGKFKNLARCKGRTAPP-----AVMDLRLKHANESSLTIMW--VMPVAEWD 820

  Fly   275 HYRVSITPDD--AIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYL 337
            :|.||:...|  .:..||..|.:       :..|..|..||:|..:|.::|.|.:|......|  
 Frog   821 NYVVSLADRDLTPVNKVLSKEAK-------EFTFNHLAQGRKYIATVTSISGDLSSRASVEGR-- 876

  Fly   338 TVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPD 402
            |||.:|.|:..:...|| ||....|  .:...:.|:|||:|...:.:......:|..:.|..:. 
 Frog   877 TVPAQVTNLNVENQGTT-SSLHADW--TKAPGDVDSYQVLLIHEKIVIKNETVSNEINKYSFHS- 937

  Fly   403 ILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVR--SLGGFLDDRSNALHISWEPAETGRQDS 465
             |:||..|.|||.|::..::|.....|....|..|.  ::..|  .||:.|.|||:|| .|..|.
 Frog   938 -LKPGGLYSVVVTTVSGGISSRQTVSEGRTVPSSVNRVTINNF--GRSDYLSISWQPA-AGDVDI 998

  Fly   466 YRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRY 530
            |.::...|.|         :.....|:.::.|.:..||.|||.|.:.|...| |...|.|....:
 Frog   999 YFVTLSHQNN---------ILPSLAISKSVNECSFSSLTAGRLYNVTVTTKS-GKYENHSYSQEW 1053

  Fly   531 TRPAAPLIQEL------RSIDQGLMLSWRSDVNSRQDRYEVHYQRNG---TREERTMATNETSLT 586
            |.|:|  :|.|      ||  ..|..||...|.. .|.|:|..:.|.   ..::.|...||...|
 Frog  1054 TVPSA--VQGLAVNNAARS--DYLKASWLRAVGD-FDIYQVTIKNNNDFIQIKDVTKTENECVFT 1113

  Fly   587 IHYLHPGSGYEV---------KVHAISHGVRSEP----------------------------HSY 614
              .|.||..|.:         |..|::.| |:.|                            |..
 Frog  1114 --NLVPGRLYSITVMTKSGNYKASAMASG-RTFPEAVKKLTLAERSSEELHVTWSRADGDVDHYE 1175

  Fly   615 FQAVFPK----PPQNL------------------------------------------TLQTVH- 632
            .|.:|..    ||..|                                          |::.:| 
 Frog  1176 IQLLFNDMKVFPPITLNNTADEYKFTSLTPGRLYKIVVLTFSGEAQRAMFVEALTVPSTVKNIHI 1240

  Fly   633 -----TNLVVLHWQAPEGSDFSEYVVR------------------------------YRTDAS-- 660
                 ||.:.::| .|.|.|...|.|.                              |:.|..  
 Frog  1241 SPNGMTNSLKVNW-TPGGGDVDSYTVSIFHHNSPIGSHTTSKHIFEHTFQNLNPGELYKVDVQTN 1304

  Fly   661 -----------------------------------PWQRISGLHE---------------NEA-- 673
                                               .||...|:.:               |::  
 Frog  1305 SGSLHKSLESFGRTIPATVHSLSADNAYSSHLLIVSWQSAKGVTDRYDILLLSDHGIVITNKSVP 1369

  Fly   674 ------RIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSR-NLTLEWPRP 731
                  :.:|:..|::|.:||.|||.|:.|. .:|......|..||:|....:|. :|:..|...
 Frog  1370 IMAKSHKFEDLVPGKKYRIQVFTVSGGLFSA-AVETEGQTVPAAVSDVKITGNSTDSLSFTWNSS 1433

  Fly   732 DGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSS--PSVR-IPIEDLSPGRQYRFEVQASSNGIRS 793
            :|.:|.|.:..:..|          ..|.|..|  |.:| ...:.|.|||.|:. |..:.:|..:
 Frog  1434 EGELDSYGIFLYNPD----------NSLHDRKSGNPDLRHCSFQGLLPGRLYKM-VIVTHSGSLT 1487

  Fly   794 GTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLA 858
            ..:.:..||:|...|.:.::|    :...|::..::.|...|   .|||...:.:|...:|||:.
 Frog  1488 NESSIHGRTVPAPVSSLQVSN----RNTSESLWFTWAPALGD---VDIYELILYNPNGTEKEKIQ 1545

  Fly   859 NDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAP 923
            :....:..|..|.||:||.:.::|.||.:.: ....:.|..|.|.:.:....|....:::.|..|
 Frog  1546 DKDLTESHFQNLVPGRLYTLVIFTHSGDLFN-KATAVGRTAPQPPNSVSFADVKINSLSIMWLGP 1609

  Fly   924 AG--EYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSV 986
            ..  :|.|||||:...|........::.::....:.||.|...|||.|...||:..         
 Frog  1610 PDWTDYDDFELQWSPKDLLVVVNPYSIGRSKGRIINGLYPGRQYTFGVQSVSGNTG--------- 1665

  Fly   987 STLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITC-QNADD 1050
                ::.:|  |.:.|:...|.|:.:..........::..|:...::    .|.:.:.| :|..|
 Frog  1666 ----KTLSP--AIFGTVRTKPDKIHHLHCRPQTSTAISCSWTPPDSD----FDGYSVECRRNGSD 1720

  Fly  1051 AADVSSYEFPVNATQGK----IDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSV 1111
              ||   ||.....:.|    |..|||...|:..|:..||   ....:.|:...|.....|.|..
 Frog  1721 --DV---EFSKRIEKDKSSITISTLVPHKRYVVSIKVHSA---DMTSQVIEDSAITMIDRPPPPP 1777

  Fly  1112 TPLEVSR-----TSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKN----ASGLEMPSWQDVQA 1167
            ..:.|::     :.|:|...|...:||:.:|.|:.:|:|::|..|.:    .:.|.:||:.|.:.
 Frog  1778 LLIRVNKKDTFISKSSIHFRFNCSWFSDTNGAVKYFTVIVSEADGNDNQRPEASLPLPSYADYKT 1842

  Fly  1168 -------YTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGT------ANCDKHQAGYCNGPLR 1219
                   .|.:.|.:..|  ||        ..::::....:||      ..||:::..||:|||.
 Frog  1843 NKSTKIYQTSYFPSRCAE--NP--------DYNIQSYKIKLGTGMELLGGKCDQNENKYCDGPLS 1897

  Fly  1220 AGTTYRIKIRAFTD----------EDKFTDTVYSSPITTERSDTVIVAATVSA-----VLLVAMV 1269
            ..|:|||.:||||.          |..::||.:|.|||||......|...||.     ::::.:.
 Frog  1898 PRTSYRISVRAFTQLFTEEMRTFPEPLYSDTFFSLPITTEAEPLFGVIEGVSGGMFVIIMIIVLT 1962

  Fly  1270 LVVVYCQHRCQLIRRASKLARMQDELAALPE-----GYI-----TPNRPVHVKDFSEHYRIMSAD 1324
            ::::|.|.:.::..:......:..::..:|.     |:|     ..:||:....|.||:..:..|
 Frog  1963 VLLIYRQKKKRVYEQDPMTTHLSSQIERIPSVHLNVGHIQIGDRISSRPILTAQFEEHFSKLQTD 2027

  Fly  1325 SDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYM 1389
            |::..|.|:|.||..||||:...|.||.||.|||::||||||.:|.||..||||..||||||:||
 Frog  2028 SNYLLSREYENLKDFGRDQSSDTALLPENRGKNRYSNILPYDSTRVKLANVDDDPCSDYINASYM 2092

  Fly  1390 PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDI 1454
            ||.|..||:|.|||||.:|:::||:|.||.|...|||:|:|.|:||.|||.|||:|:.:.:|||:
 Frog  2093 PGINFRREYIATQGPLPATKDDFWKMVWEQNVHIIVMVTQCTERGRAKCDHYWPMDQDSYYYGDL 2157

  Fly  1455 KVQLIIDTHYHDWSISEFMVSRNCES------RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDV 1513
            .||::.::...:|:|.||.:   |..      |::||||:|.|||.||||..|||::|||..||.
 Frog  2158 IVQMLSESVLPEWTIREFKI---CSEDQIDAPRLVRHFHYTVWPDHGVPETTQSLIQFVRTVRDY 2219

  Fly  1514 IG--TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVC 1576
            |.  ....|.:|||||||||:||||.|||:||.:...|.|||||.|..:|..|::|||||.|||.
 Frog  2220 INRTPGSGPTVVHCSAGVGRTGTFIVLDRMLQQVDTVDSVDIFGAVRDLRIHRMYMVQTECQYVY 2284

  Fly  1577 IHQCLLAVLEGKE 1589
            ::||:..||..::
 Frog  2285 LYQCVRDVLRARK 2297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628 66/255 (26%)
fn3 247..328 CDD:394996 21/86 (24%)
FN3 319..>749 CDD:442628 133/620 (21%)
fn3 708..796 CDD:394996 23/91 (25%)
fn3 902..978 CDD:394996 20/77 (26%)
fn3 1013..1092 CDD:394996 18/83 (22%)
PTP_tm 1127..1247 CDD:465889 40/146 (27%)
R3-PTPc 1358..1579 CDD:350396 123/228 (54%)
ptprbNP_001131088.2 beta-trefoil_Ricin_PTPRB-like 18..132 CDD:467787
Herpes_BLLF1 <131..520 CDD:282904
FN3 528..597 CDD:473895
fn3 613..690 CDD:394996 18/46 (39%)
fn3 705..779 CDD:394996 18/83 (22%)
fn3 793..872 CDD:394996 23/92 (25%)
fn3 881..954 CDD:394996 22/77 (29%)
fn3 981..1045 CDD:394996 24/74 (32%)
fn3 1057..1133 CDD:394996 21/82 (26%)
fn3 1146..1219 CDD:394996 6/72 (8%)
fn3 1233..1306 CDD:394996 12/73 (16%)
FN3 1326..1399 CDD:473895 13/72 (18%)
fn3 1412..1491 CDD:394996 22/89 (25%)
fn3 1500..1573 CDD:394996 20/79 (25%)
fn3 1588..1669 CDD:394996 20/93 (22%)
fn3 1681..1760 CDD:394996 19/90 (21%)
PTP_tm 1798..1935 CDD:465889 40/146 (27%)
R-PTPc-B 2060..2287 CDD:350465 124/229 (54%)
Blue background indicates that the domain is not in the aligned region.

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