DRSC/TRiP Functional Genomics Resources

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Protein Alignment Torsin and CLPB

DIOPT Version :10

Sequence 1:NP_572178.1 Gene:Torsin / 31399 FlyBaseID:FBgn0025615 Length:340 Species:Drosophila melanogaster
Sequence 2:NP_110440.1 Gene:CLPB / 81570 HGNCID:30664 Length:707 Species:Homo sapiens


Alignment Length:330 Identity:86/330 - (26%)
Similarity:133/330 - (40%) Gaps:61/330 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 PLQSVD----PLTIGAVGAV-----ALGAYFKEHTYCRFAECCDDRNIPARIDELERSLERTLIG 76
            |||..:    ||.....|.|     ...|.::|....|.||  :.|..|     ||:.|:..:||
Human   292 PLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAE--ERRRFP-----LEQRLKEHIIG 349

  Fly    77 QHIVRQHIVPALKAHIASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQ 141
            |......:..|::...........|||..|.|..|.||..:|:|.|..|: |.::..::.  |..
Human   350 QESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMH-KDAKKGFIR--LDM 411

  Fly   142 ADFPKESEVSNY--------RVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAF 198
            ::|.:..||:.:        ..:....:...|:.||.::.:||||||....|...:..|.|....
Human   412 SEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRL 476

  Fly   199 VDGTDNT----KAIFIFLSNTAGSHIASHLGSV------MKNGRLRE---DTRLSD--------- 241
            .||...|    .||||..||.|...||.|...:      |...|:.|   |.::||         
Human   477 TDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFK 541

  Fly   242 ---FEPLLRKAAYNMDGGMKKTTMIESHVIDHFIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQ 303
               ..|:| ||.:..|..:.:        |:..:.|||...:.:|:.:..||..|.:..||.:|.
Human   542 ENVIRPIL-KAHFRRDEFLGR--------INEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNI 597

  Fly   304 KIIED 308
            .::.|
Human   598 TLLWD 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorsinNP_572178.1 P-loop containing Nucleoside Triphosphate Hydrolases 55..175 CDD:476819 29/127 (23%)
CLPBNP_110440.1 Autoinhibitory. /evidence=ECO:0000269|PubMed:32573439 92..126
ANKYR <132..321 CDD:440430 7/28 (25%)
ANK 1 133..162
ANK repeat 137..164 CDD:293786
ANK repeat 166..197 CDD:293786
ANK 2 166..195
ANK 3 265..295 2/2 (100%)
ANK repeat 265..290 CDD:293786
ANK 4 298..327 6/28 (21%)
ClpA <339..655 CDD:440308 72/276 (26%)
Regulatory, slows ATPase and disaggregase activities. /evidence=ECO:0000269|PubMed:36170828 507..535 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

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