Protein Alignment Torsin and TOR3A

DIOPT Version :10

• Sequence 1: NP_572178.1
• Gene: Torsin / 31399
• FlyBaseID: FBgn0025615
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_071766.2
• Gene: TOR3A / 64222
• HGNCID: 11997
• Length: 397
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 91/299 - (30%)
• Similarity: 157/299 - (52%)
• Gaps: 21/299 - (7%)

  Fly    47 YCRFAECC--DDRNIPARIDELERSLERTLIGQHIVRQHIVPALKAHIASGNKSRKPLVISFHGQ 109
            ||.|.:||  .|..|......||..|...|.|||:|:|.::..::.::.: .:..|.|.:||||.
Human   105 YCSFKDCCPRGDCRISNNFTGLEWDLNVRLHGQHLVQQLVLRTVRGYLET-PQPEKALALSFHGW 168

  Fly   110 PGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQADFPKESEVSNYRVKINNAVRDTLRSCPRSLFI 174
            .||||||||..:.:.:|..|..|:.|..::....||....|..|:.::.:.:|:|.:.|.::|||
Human   169 SGTGKNFVARMLVENLYRDGLMSDCVRMFIATFHFPHPKYVDLYKEQLMSQIRETQQLCHQTLFI 233

  Fly   175 FDEVDKMPSGVFDQLTSLVDYNAFVDG--TDNTKAIFIFLSNTAGSHIASHLGSVMKNGRLREDT 237
            |||.:|:..|:.:.|...::..| .:|  .::...||:||||..|..|...:..::|.|..||:.
Human   234 FDEAEKLHPGLLEVLGPHLERRA-PEGHRAESPWTIFLFLSNLRGDIINEVVLKLLKAGWSREEI 297

  Fly   238 RLSDFEPLLR-KAAYNMDGGMKKTTMIESHVIDHFIPFLPMEKAHVIKC-----LEAELLRWRRD 296
            .:...||.|: :....:|.|...:.:::.::||:||||||:|..||..|     |..|||
Human   298 TMEHLEPHLQAEIVETIDNGFGHSRLVKENLIDYFIPFLPLEYRHVRLCARDAFLSQELL----- 357

  Fly   297 PKQANNQKIIEDIINSSISYDRTHSLFAISGCKTLEKKV 335
                ..::.:::|....:...:...||:..|||::.:::
Human   358 ----YKEETLDEIAQMMVYVPKEEQLFSSQGCKSISQRI 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Torsin	NP_572178.1	P-loop containing Nucleoside Triphosphate Hydrolases	55..175	CDD:476819	38/119 (32%)
TOR3A	NP_071766.2	Torsin	115..234	CDD:399367	38/119 (32%)