Protein Alignment Torsin and TOR1B

DIOPT Version :10

• Sequence 1: NP_572178.1
• Gene: Torsin / 31399
• FlyBaseID: FBgn0025615
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_055321.1
• Gene: TOR1B / 27348
• HGNCID: 11995
• Length: 336
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 121/337 - (35%)
• Similarity: 185/337 - (54%)
• Gaps: 25/337 - (7%)

  Fly     8 LSLCLSVLVILPLPLQSVDPLTIG-AVGAV-ALGAYFK-EHTYCRFAECCDDRNIPARIDELERS 69
            |:|.|:..|:     .:.:|:|:| |:||. |:..|.. ...||||||||.:.. |.....|:..
Human    13 LALLLAARVV-----AAFEPITVGLAIGAASAITGYLSYNDIYCRFAECCREER-PLNASALKLD 71

  Fly    70 LERTLIGQHIVRQHIVPALKAHIASGNKS-RKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSN 133
            ||..|.|||:..:.|..||...  ..||: :|||.:|.||..|||||||::.:|:.::.||.:||
Human    72 LEEKLFGQHLATEVIFKALTGF--RNNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLHPKGLKSN 134

  Fly   134 YVTKYLGQADFPKESEVSNYRVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAF 198
            :|..::....||.|.::..|:.::...:|..:.:|..|:|||||:||:..|:.|.:...:||...
Human   135 FVHLFVSTLHFPHEQKIKLYQDQLQKWIRGNVSACANSVFIFDEMDKLHPGIIDAIKPFLDYYEQ 199

  Fly   199 VDGTDNTKAIFIFLSNTAGSHIASHLGSVMKNGRLREDTRLSDFEPLLRKAAY-NMDGGMKKTTM 262
            |||....|||||||||..|..|........:.||.|||.:|.|.||:|....: |...|:..:.:
Human   200 VDGVSYRKAIFIFLSNAGGDLITKTALDFWRAGRKREDIQLKDLEPVLSVGVFNNKHSGLWHSGL 264

  Fly   263 IESHVIDHFIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQKIIEDII----NSSISYDRTHSLF 323
            |:.::||:||||||:|..||..|:.||:        :|....|.|||:    .....:.|...::
Human   265 IDKNLIDYFIPFLPLEYRHVKMCVRAEM--------RARGSAIDEDIVTRVAEEMTFFPRDEKIY 321

  Fly   324 AISGCKTLEKKV 335
            :..||||::.::
Human   322 SDKGCKTVQSRL 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Torsin	NP_572178.1	P-loop containing Nucleoside Triphosphate Hydrolases	55..175	CDD:476819	40/120 (33%)
TOR1B	NP_055321.1	P-loop containing Nucleoside Triphosphate Hydrolases	55..176	CDD:476819	43/123 (35%)
		ClpA	<172..239	CDD:440308	31/66 (47%)