Protein Alignment CG12179 and alms1

DIOPT Version :9

• Sequence 1: NP_572175.3
• Gene: CG12179 / 31393
• FlyBaseID: FBgn0025388
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_690375.6
• Gene: alms1 / 561882
• ZFINID: ZDB-GENE-030131-4837
• Length: 2105
• Species: Danio rerio
• Alignment Length: 1604
• Identity: 328/1604 - (20%)
• Similarity: 551/1604 - (34%)
• Gaps: 518/1604 - (32%)

  Fly    44 LDRF------MALSSTASSGASGSTHS-----CALGSVPPPGCASMEHE-------SRPESGHRR 90
            |.||      :.||||.|| :.||.|.     .::|:.  ....|:|.:       |||.|....
Zfish   673 LGRFSDVSSSVNLSSTLSS-SQGSYHGEQSMRASVGAA--SSVVSLEVDNYAPYWTSRPTSPPHT 734

  Fly    91 RTKSSDHRSPDERGEAKEQLRELSVSPPPSKHKISQFT----------SPKSEVT---------- 135
            |..:.:.|.|       ..|..|.:...||. .::.||          ||....|
Zfish   735 REFNIEDRIP-------LYLLNLGIDQSPST-ILNPFTRRGPIREPEFSPTDLCTIKGSIGTPTK 791

  Fly   136 KTKPNEYTIIPIVLASSPSFRSVAVTQT---------MSQSAED-----IRTPTKSPQMQNKKTQ 186
            .|:|:|...:.....||.|..|...:.:         :||.|.|     |.|...:.|:|:  |.
Zfish   792 STQPSEVDSLQKETFSSSSQHSTESSASVSHHLSVHELSQPATDSSVKVILTQADAAQLQS--TS 854

  Fly   187 TPESVLKSHKRLEWDPSADVGYCKRAMSMSNISTLERSVL---EDCSWRQPTQQ-------RPEA 241
            .|.:.|:         .:|....:|:.|:....:..|.|:   :|......|..       |.|:
Zfish   855 HPSTTLQ---------QSDAAESERSFSLPVPESGPREVVKADDDSLVGSGTLHEIRRLLGRAES 910

  Fly   242 NLDGVQPLLAEEPSPMLDKPTPPLA--------------------CSTFVNRSERTKSLNSGMES 286
            .:.|...|.:...|..|.:....|.                    .|..:.||    |.:|.::.
Zfish   911 LVSGRSSLTSSPGSHRLSESDTSLVSLGRNARGYHTDTSLSAGGNLSLLLTRS----SSDSALKG 971

  Fly   287 SLSSNKGDPR------KKCQRKSRRQDSEVSSCQTDCRSSSQKESTQGSSEAKDIRG--NFTTEG 343
            ||||::|...      |.......|::|..:   .|.|.:.::...:|.|.|...:|  ..||.|
Zfish   972 SLSSSQGPQHIDLTTVKPAALSLSREESLKA---RDLRVTPRRAEPEGCSAADPDKGKPTTTTSG 1033

  Fly   344 TQCSYNRNDTEIDSIMEEEESIDRRKKDDLRISSRVQDPQISSRRPSVS--SSRRESLSSYRRDD 406
            ||.:       :.||   ..|:.:.::|      ..:|..|.|...|:|  |:..||||
Zfish  1034 TQIN-------LPSI---AVSVPQNEED------TSEDAPIGSSENSLSHVSAEAESLS------ 1076

  Fly   407 SRLNSPNSSRLGSEVSSRVESSRSSSRRESQTNSVYGSLSASSFDYHMHMAQEVEVLKHNQRRQQ 471
               :|.:.|.|.:.|:..::|       ||..:.|  :...|:.|.....|:|..::|.:.||.:
Zfish  1077 ---DSSSESSLAARVAKLLQS-------ESPVSMV--TSRPSTADPEDSRAREWILMKVSGRRCE 1129

  Fly   472 EMEV--EPKKQLEKEQHQNDMQQGEPKGRELKDKNHHS--GREQQEIQPLMRDQRKAEQRHEKDH 532
            .:|:  |.:|::|:.:.:..:.....|.....:.:..|  |.|.|:.:..: ..|..|.|  ...
Zfish  1130 SLELNTEDRKRIEEIKRELLLNTKYTKWSSDSEGSAQSSIGLESQQTKGYV-GLRNMENR--LSD 1191

  Fly   533 QLEREQQG----IQQLSKGQRKAKKRE---KEREQERQYTAAQFEKIRSNRRHVNKENQKPENPV 590
            ||::....    :|.|     :||..|   :|....:.:|:.   .|.:.||     ...|::|.
Zfish  1192 QLQKAPSNPLSTVQDL-----EAKVHEIALREGFSTKPFTSI---TISTTRR-----TPSPQSPP 1243

  Fly   591 VNPSTGVTASTSTTSLDVGSGSR-PGGELDLG---------IDLLCSLVKSRSLSQGQKKKLVRD 645
            .:|.||....|     :|||.:. |.|..|..         ||       .:..::.:::..:.|
Zfish  1244 HSPVTGTLKIT-----NVGSANETPAGTKDSDREKETEGQHID-------EKKTTEDKQENTITD 1296

  Fly   646 IARRISCLE--LTESSTSSRS--------LSSSSKEQLK------------------VPTGS--- 679
            .|:|:|.::  :|.|:.:::|        ||...|.|::                  ||:.:
Zfish  1297 KAQRMSHIDYNVTSSTFNNKSHLSHIHVTLSPKPKNQIRFEKSTQNISQDVALQRPIVPSVADPQ 1361

  Fly   680 ------------------LQQVAATNTNQSNAR-------SSSKAERIAPPVPAPRKRAAIGSSS 719
                              .::|...||.:.:||       ||:.:.|:.........:.|.|:::
Zfish  1362 LEPMHRISTLNHVSSYEYRERVQGQNTGRVSARFPARHTQSSAPSNRLDMKSRTLSGQTAYGTAA 1426

  Fly   720 PLPESVSYSGSTSGSGEVI----TQKTNIPNRNASTDADIEPLDLQDWLNPMTLSEIEFEERLKG 780
             :|..:.|  ...||.|:.    ......|.|:.:|.....| |..|.:.|      .|.:.:.|
Zfish  1427 -VPTLLPY--KPHGSSELFYMPQVDPELSPGRSDTTVESSHP-DSDDAVPP------HFNKDILG 1481

  Fly   781 GTDSE-------RRRQLHWVKTEINRMQEFKNLLENISLPSKSQKKANTESATAAQI-PSSMRCM 837
            ..:.|       .:..::..:|.:|:          :|......|.|:|..:||.:: ..:|..:
Zfish  1482 SREQEDNTITPKHKEGIYSKRTNMNK----------VSSGDCPPKSASTFVSTAPEVSKKNMETV 1536

  Fly   838 GDQKERPDKE-YLLRQEMSAEAESKEMENSETTTTPPPPVRIESVGVNVTNSDPSTLPAPPPTQP 901
            |...|..||| :.:...|.|: .|.:..:...:||..|.:                     |.:|
Zfish  1537 GIDAEYNDKEDHFVPLNMEAD-NSMDHVHFHNSTTQEPKI---------------------PREP 1579

  Fly   902 PPPPPHLNQRNLQNRKKMATPLLVSGSSTSGGGRSESVCSFVQQRQRQFREHYQNQQQQQFVLLQ 966
            .......|:|..:..||        |...:....|..:.|.:.|..|:|.|.:..::
Zfish  1580 HYSSSQPNRRPYRGNKK--------GKDRTPHDVSLEITSSLDQLWRRFNEKWSTEE-------- 1628

  Fly   967 QQKLYQLQKQLNQQKDILIQRQQHCGQCAQCGHQRT----CIHQQNCP-------RRQQEAEEQ- 1019
                   .:.:|..:..|:.|.:...:..   |..|    .:.|.:..       .|.||.|||
Zfish  1629 -------SRSINDGETSLLDRLERLSRLI---HNTTPTDHSVQQSSDSGNGEYDRMRNQEEEEQR 1683

  Fly  1020 -------------------------PDEREQYMQ---------MQYAQAAGSAYATPHQSGSSGA 1050
                                     |.||::.::         .:..|.|..|:....:...|
Zfish  1684 ERVQLKAPPKHAWVQDEGQGKVHLCPAERDESVETSSSVSTVDTERLQRAFGAHRVAREGMKS-- 1746

  Fly  1051 DKNEAIYYQVVNSQGVASYVQAT---MVSTETQNEASATGGAGGSAI------------------ 1094
            |.:....|..:|::..:....:|   .||..|.|...:|..||..:.
Zfish  1747 DGSLLRLYNSINAKKTSRRKPSTKDAAVSVTTDNTDDSTVSAGSLSSSSTSFHHSQRGVYSLKTK 1811

  Fly  1095 --------------------------TRSTTTTTNSSSSMMCISSDMSVPMGMMN-----TCETT 1128
                                      ||...|...|..:...:||......|:.|     |..|.
Zfish  1812 KSKVKLVSKSVQAGDLEIVINGTRKHTRDVGTVFPSPGAFKNVSSSNKFGSGLQNGIPIPTASTA 1876

  Fly  1129 TTTTTHQYDDVACQRVRR------------------GHKETTMNAES------------------ 1157
            ....|....|.:.:.||.                  |.||.....||
Zfish  1877 KPIQTALKRDSSNKSVRTRYPHGVSWFVSADELKFDGRKENQPQNESEPSISQAWFEPYSRTRPW 1941

  Fly  1158 --------MQRQTLQVRPRAISYVIQFTPTG-SSEVIEKPP-----SLQDQLQLARPEFCANAKQ 1208
                    .:||..|.:.|...     |.|. .:::.:|..     |||:.|:|.||||.:.:::
Zfish  1942 RESSREPLRERQNQQEQERQTE-----TRTAMETDISDKTSALVRLSLQEALELHRPEFVSRSRE 2001

  Fly  1209 RKAIL------NEMQMIRNARRQELDNVLSQSTSMEALNRHLEQLPPPANTRVRLFTTREMKAIT 1267
            |...|      ..:|.|.|..|:||.|       ..|.:|.|...|.|   |.|:...:||...:
Zfish  2002 RMKRLGLLVEERRLQAIFNREREELFN-------FPAPSRPLRAAPVP---RKRVVPRKEMVQRS 2056

  Fly  1268 SKRCKNLPEVLAAQSRQEEEQRR---RSNRLMRDVFNKRLKSRV 1308
            .::...||||   |.|:|||:||   ||.||...:|||::.:||
Zfish  2057 REKYAKLPEV---QKRREEEKRRAEYRSYRLTAQLFNKKVTNRV 2097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12179	NP_572175.3	ALMS_motif	1190..1309	CDD:291955	47/128 (37%)
alms1	XP_690375.6	ALMS_motif	1980..2101	CDD:291955	47/131 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10748
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000