Protein Alignment Cmtr1 and CMTR1

DIOPT Version :10

• Sequence 1: NP_572148.2
• Gene: Cmtr1 / 31355
• FlyBaseID: FBgn0029693
• Length: 788
• Species: Drosophila melanogaster
• Sequence 2: NP_055865.1
• Gene: CMTR1 / 23070
• HGNCID: 21077
• Length: 835
• Species: Homo sapiens
• Alignment Length: 794
• Identity: 304/794 - (38%)
• Similarity: 450/794 - (56%)
• Gaps: 87/794 - (10%)

  Fly    25 YSNKAMEMMKKMGYENDKGLGKSNQGRLEPIIAVQQDGRRGFGLKL------------DTVQSSA 77
            |::.:.::|.|||:...:||||.:|||.:.:.|..|.||||.||.|            |..:.||
Human    87 YNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSA 151

  Fly    78 GQ---WDPACEELEIPEPVLWLHNPGSRADAYSLDQLMGHLVTGEKKLTLDGETRYCDPAILHHI 139
            .:   |.|.| ..|||:                ..::...:|.|::|:.::.||.:|...:||.:
Human   152 CEQVSWFPEC-TTEIPD----------------TQEMSDWMVVGKRKMIIEDETEFCGEELLHSV 199

  Fly   140 LNAKTVFDDLNDNEKRRARSRCNPFETIRSSIFLNRAAVKMANIDSMCNFMFTNPRDPAGQTLV- 203
            |..|:|||.|:..|.||||:|.||:|.||...||||||:||||:|.:.:.|||||||..|:.||
Human   200 LQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVK 264

  Fly   204 -APDELLYFTDMCAGPGGFSEYVLYRKSWEAKGFGFTLRGANDFKLEKFFAASPESFDTFY---G 264
             ...|||||.|:||||||||||||:||.|.|||||.||:|.||||||.|::||.|.|:.:|   |
Human   265 DREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGG 329

  Fly   265 VKEDGNIFDESNQDSLNEYIRMHTP-QGVHFAMADGGFSVEGQKNIQEILSKQLYLCQFLTALKI 328
            :..||:|....|..:...::..:|. :||||.|||||||||||:|:||||||||.|||||.||.|
Human   330 IDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSI 394

  Fly   329 LRPNGSFVCKVFDLFTPFSVGLVYLMYKCFQQIAIIKPNSSRPANSERYLVCKYKRSDAETAGIV 393
            :|..|.|:||.||||||||||||||:|.||:::.:.||.:|||||||||:|||..:...:  .:.
Human   395 VRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGID--DVR 457

  Fly   394 AYLNTVNLMLSDESQLDENDVLEIFNANELAEDEDFLRYIIDSNNAIGKKQIVGLRKIAAFAQNL 458
            .||..||:.|:.....| :||..:.....:..|.:|..|:|.||.:....||..|.||.||.|:.
Human   458 DYLFAVNIKLNQLRNTD-SDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDT 521

  Fly   459 ELKETKQSEVRQECLKRWGLPDKLRQAPENKPTDRLLDELLADWANERSWLSLPATEMKGVASLN 523
            .|.|.:|:|:|:|||:.||:||:.|.||.:........||            :..||: .:.|..
Human   522 TLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFEL------------IQGTEI-DIFSYK 573

  Fly   524 AT---------IKNVADWYFVPVGREETNINACSLFLCKSRGNLLRYT----EHKKWELVETAFE 575
            .|         |:.|.|:..:..|.|:.       ||. ..|....||    :..:|..::...|
Human   574 PTLLTSKTLEKIRPVFDYRCMVSGSEQK-------FLI-GLGKSQIYTWDGRQSDRWIKLDLKTE 630

  Fly   576 VQPRSIFFGQIVYEFYGEGRTIQRMAALHIIDGICLGGVDIRRRPYRERVSMCDKFARSLNKPYR 640
            :...::...:||:|..|||:..::::|:||:|.:.|.|.|:|.:.:.:|:.:.:||.::::||.|
Human   631 LPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSR 695

  Fly   641 KDRTFGALRSKPLFRLQDMGSFFANMRHYVLKDNS--QRLGFALDDNKFFVPGGIMMFCELTNNY 703
            .|  ...:|.|.::||::|...|..:...::|.:|  .:|.:...|::.|||.|:.:...:...:
Human   696 PD--MNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPW 758

  Fly   704 VSAHSRSRGQLYYFNVRNKESYYKDQIPRNKADEIFASFRFSFSCRLLWKWTD-LRQVEELATED 767
            ....|:|..:.:::|.:.|:|.:  .:|   ||.| |.|...:..||.|:|.| :|..:....:|
Human   759 TMGFSKSFKKKFFYNKKTKDSTF--DLP---ADSI-APFHICYYGRLFWEWGDGIRVHDSQKPQD 817

  Fly   768 NPKILFRSDFVKFI 781
            ..| |.:.|.:.||
Human   818 QDK-LSKEDVLSFI 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cmtr1	NP_572148.2	G-patch	25..69	CDD:396249	19/43 (44%)
		FtsJ	172..383	CDD:426399	136/216 (63%)
CMTR1	NP_055865.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67
		Bipartite nuclear localization signal. /evidence=ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000305|PubMed:24402442	2..19
		G-patch	87..129	CDD:396249	18/41 (44%)
		FtsJ	232..448	CDD:426399	135/215 (63%)
		Adenylation_DNA_ligase_like	<625..716	CDD:448381	27/92 (29%)
		Interaction with POLR2A. /evidence=ECO:0000269|PubMed:18533109	727..835		30/111 (27%)