DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42541 and GEM

DIOPT Version :9

Sequence 1:	NP_996345.3	Gene:	CG42541 / 31344	FlyBaseID:	FBgn0260658	Length:	1418	Species:	Drosophila melanogaster
Sequence 2:	NP_005252.1	Gene:	GEM / 2669	HGNCID:	4234	Length:	296	Species:	Homo sapiens

Alignment Length:	282	Identity:	85/282 - (30%)
Similarity:	119/282 - (42%)	Gaps:	71/282 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   916 SMPAESRRPRLAEMRRSAIHAGDPDMTYYRLRSFSITSHGICNLGDSLRSRRSRSINSVTSTGTS 980
            |:||:.|...:.:         :|....:|.| .|.|....|        |||.|.:|..|..:|
Human    23 SIPADGRHLMVQK---------EPHQYSHRNR-HSATPEDHC--------RRSWSSDSTDSVISS 69

  Fly   981 NSGVDRHNSNASGASGEVIDGDPNVPAYKIAMLGASGVGKTTLTYQFT----TSDYIC------A 1035
            .||    |:                 .|::.::|..||||:||...|.    :.|..|      .
Human    70 ESG----NT-----------------YYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDT 113

  Fly  1036 YDLSLDDDYGQKTVSVLVDNIETDLE---IIDHPACEMSTEAFCATYNIDLFVVVYSVIDRNTFA 1097
            |:.:|..| |:....:|:|..|...|   :.||          |.... |.:::|||:.||.:|.
Human   114 YERTLMVD-GESATIILLDMWENKGENEWLHDH----------CMQVG-DAYLIVYSITDRASFE 166

  Fly  1098 AAERVLQYLKENEMLLSRGAILVANKTDLQRHRVVTRQMGRKVAKEIACKFIETSSGLDHNVDEL 1162
            .|..:...|:..........|||.||:||.|.|.|:...||..|....|||||||:.:.|||.||
Human   167 KASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKEL 231

  Fly  1163 LVGIVAQVKL-------NPQRL 1177
            ..|||.||:|       |.:||
Human   232 FEGIVRQVRLRRDSKEKNERRL 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42541	NP_996345.3	RGK	1008..>1175	CDD:206715	63/186 (34%)
CG42541	NP_996345.3	small_GTPase	1008..1171	CDD:197466	60/175 (34%)
GEM	NP_005252.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..68		12/39 (31%)
		RGK	76..296	CDD:206715	65/190 (34%)
		Calmodulin-binding. /evidence=ECO:0000250	266..285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920