Protein Alignment CG42541 and GEM

DIOPT Version :10

• Sequence 1: NP_996345.3
• Gene: CG42541 / 31344
• FlyBaseID: FBgn0260658
• Length: 1418
• Species: Drosophila melanogaster
• Sequence 2: NP_005252.1
• Gene: GEM / 2669
• HGNCID: 4234
• Length: 296
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 85/282 - (30%)
• Similarity: 119/282 - (42%)
• Gaps: 71/282 - (25%)

  Fly   916 SMPAESRRPRLAEMRRSAIHAGDPDMTYYRLRSFSITSHGICNLGDSLRSRRSRSINSVTSTGTS 980
            |:||:.|...:.:         :|....:|.| .|.|....|        |||.|.:|..|..:|
Human    23 SIPADGRHLMVQK---------EPHQYSHRNR-HSATPEDHC--------RRSWSSDSTDSVISS 69

  Fly   981 NSGVDRHNSNASGASGEVIDGDPNVPAYKIAMLGASGVGKTTLTYQFT----TSDYIC------A 1035
            .||    |:                 .|::.::|..||||:||...|.    :.|..|      .
Human    70 ESG----NT-----------------YYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDT 113

  Fly  1036 YDLSLDDDYGQKTVSVLVDNIETDLE---IIDHPACEMSTEAFCATYNIDLFVVVYSVIDRNTFA 1097
            |:.:|..| |:....:|:|..|...|   :.||          |.... |.:::|||:.||.:|.
Human   114 YERTLMVD-GESATIILLDMWENKGENEWLHDH----------CMQVG-DAYLIVYSITDRASFE 166

  Fly  1098 AAERVLQYLKENEMLLSRGAILVANKTDLQRHRVVTRQMGRKVAKEIACKFIETSSGLDHNVDEL 1162
            .|..:...|:..........|||.||:||.|.|.|:...||..|....|||||||:.:.|||.||
Human   167 KASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKEL 231

  Fly  1163 LVGIVAQVKL-------NPQRL 1177
            ..|||.||:|       |.:||
Human   232 FEGIVRQVRLRRDSKEKNERRL 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42541	NP_996345.3	Amelogenin	<477..>550	CDD:197891
		RGK	1008..>1175	CDD:206715	63/186 (34%)
GEM	NP_005252.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		12/39 (31%)
		RGK	76..296	CDD:206715	65/190 (34%)
		Calmodulin-binding. /evidence=ECO:0000250	266..285