DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2930 and SLC15A3

DIOPT Version :10

Sequence 1:NP_001284845.1 Gene:CG2930 / 31341 FlyBaseID:FBgn0028491 Length:815 Species:Drosophila melanogaster
Sequence 2:NP_057666.1 Gene:SLC15A3 / 51296 HGNCID:18068 Length:581 Species:Homo sapiens


Alignment Length:727 Identity:138/727 - (18%)
Similarity:249/727 - (34%) Gaps:295/727 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 EFCERFNYYGMRTVLVLYL-SRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILY 203
            |..||..::|:...||||| |....::.:.||....:|....|.|...|..::|.:||:::.:..
Human    42 EMLERAAFFGVTANLVLYLNSTNFNWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVAL 106

  Fly   204 LSLVYICGSVLLTLGA----------------IGP----LNLPMET-------FTMLGLALIALG 241
            ..|:|:..|.||...|                :||    ...|..:       ....||.|:.|.
Human   107 SLLLYLAASGLLPATAFPDGRSSFCGEMPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLA 171

  Fly   242 SGGIKPCVSAFGGDQFKVPEQVKQIT-SFFSLFYFSINAGSLISTTVTPILREDVSCFDDINCYP 305
            :..::..:::||.||  |.:..:..| .||:.||:|||.|:::|..|...:::::|       :.
Human   172 ASSVRSNLTSFGADQ--VMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQQNIS-------FL 227

  Fly   306 LAFGVPAVLMIVSVIIFVLGRSLYKMKPPAGNMVVLVSSTIWTALTTKCKEKKTNPREHWLDYA- 369
            |.:.:|...:.::..||:....::..|||.|:.   |||.:..||...|.:.       |..:: 
Human   228 LGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQ---VSSMLKLALQNCCPQL-------WQRHSA 282

  Fly   370 -DKKYDRQLIDD---------------VKVLMRVLFLYLPLPVFWALFDQQGSRWTFQ------- 411
             |::..|.|.|:               .:||:::|.:.:.|..:|.::.|..|.:..|       
Human   283 RDRQCARVLADERSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIP 347

  Fly   412 ------------ATRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYDVALYPAL---KLVGIRRPL 461
                        |.|..|  .|:.|....|.:.|.:::||.:||.|..:.|.|   ||  :...|
Human   348 NIFPANPANISVALRAQG--SSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKL--LPSAL 408

  Fly   462 QKLTMGGILAGIAFIISGVVELSLEKTYPDLPYSQNIQLRIFNADNCDYFFTSNIPGAENVTVTS 526
            ||:.:|......:.|::||:|  :|:.:                                     
Human   409 QKMALGMFFGFTSVIVAGVLE--MERLH------------------------------------- 434

  Fly   527 LNAYTNKDIYAPGSLDVEFSLSSASEACTISADKIPKVLTDNTAWSLFLNPLNGSGYYWEEDFVD 591
                                                                             
Human   435 ----------------------------------------------------------------- 434

  Fly   592 KPSQSHPLIRNVANVPQELSIRWEKASTGEVVYDDLASKTLLTRVNSAEYVVMVGERNVGTFDVH 656
                   .|.:...|.|::         |||:|            |:|                 
Human   435 -------YIHHNETVSQQI---------GEVLY------------NAA----------------- 454

  Fly   657 TGGVYTLLIKDNNNIYEANLEEVTSPNSVKILWLVPQYVVMTLGEVMFSVTGLEFSYAQAPPSMK 721
                                       .:.|.|.:|||:::.:.|:..|:.||||:|::||.||:
Human   455 ---------------------------PLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQ 492

  Fly   722 SVLQACWLLTVAFGNV----IVVVIA------------------EAALFESQASEFFLFAGLMFA 764
            ..:...:......|::    :|.:::                  ...|:      |||.||:...
Human   493 GAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPKDFGNINNCRMDLY------FFLLAGIQAV 551

  Fly   765 DMLIFMVMAYYY 776
            ..|:|:.:|..|
Human   552 TALLFVWIAGRY 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2930NP_001284845.1 rad23 <15..>83 CDD:273167
2A1704 145..776 CDD:273343 134/720 (19%)
SLC15A3NP_057666.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
MFS_SLC15A3_4 38..562 CDD:340906 137/724 (19%)
Blue background indicates that the domain is not in the aligned region.

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