DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2901 and xpr1

DIOPT Version :9

Sequence 1:	NP_570077.1	Gene:	CG2901 / 31338	FlyBaseID:	FBgn0029679	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001016753.1	Gene:	xpr1 / 549507	XenbaseID:	XB-GENE-1015946	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	677	Identity:	272/677 - (40%)
Similarity:	393/677 - (58%)	Gaps:	62/677 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTYESHLTIEWRQQYMRYGDLKELIKQGVENAPSPLTSSDYEVQAYYKAFEETFLTECQSE 65
            |||.:...:|:|.|||:||::|...||::....:.|||...:.:..|:.||..|||.|...|:.|
Frog     1 MKFAEHLSAHITPEWRKQYIQYEAFKEMLYAAQDQAPSIEVTDEDTVKRYYAKFEEIFFQTCEKE 65

  Fly    66 LTGVNNFFLEKLLEARRKHGHLKLQL---LAYSRE----PGHTGSDSSLSQR---------AERS 114
            |..:|.|:.|||.||:|:...|:.:|   |...||    ||       |.||         .||.
Frog    66 LAKINTFYSEKLAEAQRRSATLQNELQSSLDAQRESSAIPG-------LRQRRKAVFALTHEERV 123

  Fly   115 QKKLMTTRQLRYAYAEFYLSLVLIQNYQSLNETGFRKICKKYDKNMRSVAAGRWFVENVLDAPFT 179
            |.:  ..:.|:.|::||||||:|:||||:||.||||||.||:||.:.:.....|.|.:|..|||.
Frog   124 QHR--NIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFY 186

  Fly   180 DVRLLQRMTIEVEDLYTTHLANGDRSLAMEKLRVPPLG--EPTPPSMVFRAGIALGMLIMLLVAT 242
            ..:.:.::..|.|.:.|..|.:|||..||::|||||||  :|.|....||.|:..|:.|:|.:|.
Frog   187 TCKKINQLISETETVVTNELESGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLYCGIFIVLNMAI 251

  Fly   243 AISYWKRAPLEDHTPGLMRLFRGPFTWVIFNFYMAANVAGWQQAGVNHILIFEIDPRSHLQPATF 307
            .::.......:|..| ::|::||.|..:.|.|.:..|..||:||||||:||||::||::|.....
Frog   252 IMAGSHYLLGKDVWP-MVRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHL 315

  Fly   308 LEIACTFGILWALSMLGFLYNDLIGVSDPYVFPLGLILIMVGLLVVPLPIMNWPARWWTIKLVGR 372
            .|||...||||..|:...::...|.: ..::.||.|..:|:..||.|.....:.:|:|.:||:.|
Frog   316 FEIAGFLGILWCFSLFSCIFGLWINL-QMHLNPLILYGLMLLFLVNPTKTFYYKSRFWLLKLLFR 379

  Fly   373 VITAPLHYVGFADFWMGDQMNSLVSCIVDHYYTVRFYA--ISWLRYD-------RVNNCFEPDVM 428
            |.|||.|.|||||||:.||:|||...::|..:.:.||:  :.|...|       .|.|.:...|.
Frog   380 VFTAPFHKVGFADFWLADQLNSLAVILMDLEFMICFYSFELKWGDSDGLVNSANSVCNSYSYGVR 444

  Fly   429 VPITMCLPGWFRFAQCLRRFRDSGSKSMSYLINAGKYSTTFLVVLFSTL------RRNSEGGYAN 487
            . :..|:|.|.||.|||||:||: .::..:|:|||||||||.:|.|:.|      |.:|:   |.
Frog   445 A-VVQCIPAWLRFIQCLRRYRDT-KRAFPHLVNAGKYSTTFFMVTFAALYSTHKERNHSD---AQ 504

  Fly   488 TFSNPYTWL---FLSSCVVATIYCYLWDVIRDFGLFRIMRGERIFLRKQLVYPQ-AFYYFVIVEN 548
            .|.  |.|:   .:|||     |..:||:..|:|||....||..|||:::|||| |:||..|:::
Frog   505 VFF--YLWIIFYLISSC-----YTLIWDLKMDWGLFDRNAGENTFLREEIVYPQKAYYYCAIIQD 562

  Fly   549 LVLRLFWAVEFTILYHNLMTPYN--MRTISSILEITRRFIWNYVRLENEHLFNCGNFRATRDIHL 611
            ::||..|.::.::...||.|...  :.|:.:.||:.|||:||:.|||||||.|||.|||.|||.:
Frog   563 VILRFAWTIQISVTSLNLFTDAGDIISTVLAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISV 627

  Fly   612 AALNPRQERMLESMMDESDGVSNRRKS 638
            |.||...:.:||.|||:.|||.||.||
Frog   628 APLNADDQTLLEQMMDQDDGVKNRVKS 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2901	NP_570077.1	COG5408	1..162	CDD:227695	72/176 (41%)
		SPX_XPR1_like	2..158	CDD:269898	69/171 (40%)
		EXS	260..597	CDD:281164	141/357 (39%)
xpr1	NP_001016753.1	SPX_XPR1_like	2..165	CDD:269898	69/171 (40%)
		SPX	3..169	CDD:281146	70/174 (40%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	158..165		4/6 (67%)
		EXS	269..613	CDD:281164	141/356 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030