DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myc and MYCN

DIOPT Version :10

Sequence 1:NP_525062.2 Gene:Myc / 31310 FlyBaseID:FBgn0262656 Length:717 Species:Drosophila melanogaster
Sequence 2:NP_005369.2 Gene:MYCN / 4613 HGNCID:7559 Length:464 Species:Homo sapiens


Alignment Length:300 Identity:65/300 - (21%)
Similarity:108/300 - (36%) Gaps:96/300 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   457 FNLPYTPASSSPVKSVANSRYPSPSSTPYQNCSSAS----------PSYSP-------------- 497
            |..|......:||.:       :|:|.|....:.||          |..:|              
Human   193 FPFPVNKREPAPVPA-------APASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHK 250

  Fly   498 -LSVDSSNVSSSSSS---------------------SSSQSSFTTSSSNKGRKRSSLKDPGLLIS 540
             ||....:..|.|..                     |||.:...|:.:...|.:::...||...|
Human   251 ALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQS 315

  Fly   541 SSSVY---LPGVNNKVTHSSMMSKKSRGKKVVGTSSGNTSPISSGQDV--------DAMDRNWQR 594
            |..:.   || ::.:..:::                  .||....:|.        :|..|..:.
Human   316 SELILKRCLP-IHQQHNYAA------------------PSPYVESEDAPPQKKIKSEASPRPLKS 361

  Fly   595 RSGGIATSTSSNSSVHRKDFVLGFDEADTIEKRNQHNDMERQRRIGLKNLFEALKKQIPTIRDKE 659
            .....|.|.|..:|          |..|: |:|..||.:|||||..|::.|..|:..:|.:...|
Human   362 VIPPKAKSLSPRNS----------DSEDS-ERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNE 415

  Fly   660 RAPKVNILREAAKLCIQLTQEEKELSMQRQLLSLQLKQRQ 699
            :|.||.||::|.:....|..||.:|.::::  .||.:|:|
Human   416 KAAKVVILKKATEYVHSLQAEEHQLLLEKE--KLQARQQQ 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MycNP_525062.2 bHLHzip_Myc 626..702 CDD:381406 26/73 (36%)
MYCNNP_005369.2 Myc_N 10..372 CDD:460045 33/204 (16%)
Interaction with AURKA. /evidence=ECO:0000269|PubMed:27837025 19..47
Interaction with AURKA and FBXW7. /evidence=ECO:0000269|PubMed:27837025 61..89
9aaTAD. /evidence=ECO:0000269|PubMed:34342803 76..84
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 129..172
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..294 17/104 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 334..392 16/86 (19%)
bHLHzip_N-Myc_like 378..464 CDD:381462 28/78 (36%)
Leucine-zipper 433..454 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

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