Protein Alignment CG3526 and RNF125

DIOPT Version :10

• Sequence 1: NP_726832.2
• Gene: CG3526 / 31277
• FlyBaseID: FBgn0040355
• Length: 229
• Species: Drosophila melanogaster
• Sequence 2: NP_060301.2
• Gene: RNF125 / 54941
• HGNCID: 21150
• Length: 232
• Species: Homo sapiens
• Alignment Length: 191
• Identity: 42/191 - (21%)
• Similarity: 62/191 - (32%)
• Gaps: 55/191 - (28%)

  Fly    16 PRRRQIGHTSGHCNVRCDGCGNNRMTFYRYKCLHC-------------------LDYDLCSDCKE 61
            |.|.:.||      |.|..|....:...::.|.:|                   .:|..|::|
Human    47 PVRTRCGH------VFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAEC-- 103

  Fly    62 NGVSNGLHSLDHPLQCLMDRDALELHFAG--------EPIPIL--CADSFTCPVCGEMGFSVEDL 116
                       ..|.||.:   :..|...        .|:..|  .|....||.| :.....:.|
Human   104 -----------DTLVCLSE---MRAHIRTCQKYIDKYGPLQELEETAARCVCPFC-QRELYEDSL 153

  Fly   117 RTHCQDNHRMARTVCICPVCAAVPLSQPSHIA-HIANHLMFSPSHRATGDPMIDISATSQA 176
            ..||..:||..|....||:|..:|...||..: .:..||..  ||....|..||.:...:|
Human   154 LDHCITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQV--SHTLFYDDFIDFNIIEEA 212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3526	NP_726832.2	ZZ_PCMF_like	30..78	CDD:239078	9/66 (14%)
		zf-Di19	99..149	CDD:428539	15/50 (30%)
RNF125	NP_060301.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		RING-HC_RNF125	34..83	CDD:438204	9/41 (22%)
		Interaction with the C2HC RNF-type zinc finger. /evidence=ECO:0000269|PubMed:27411375	43..45
		zf_C2HC_14	94..126	CDD:465807	7/47 (15%)
		Interaction with the RING-type zinc finger. /evidence=ECO:0000269|PubMed:27411375	109..113		1/6 (17%)
		Linker region. /evidence=ECO:0000269|PubMed:27411375	120..128		0/7 (0%)
		zf-Di19	141..>173	CDD:428539	11/32 (34%)
		Required for interaction with ubiquitin and for autoubiquitination. /evidence=ECO:0000269|PubMed:17990982	210..224		1/3 (33%)