Protein Alignment Syx4 and STX3

DIOPT Version :10

• Sequence 1: NP_525057.2
• Gene: Syx4 / 31269
• FlyBaseID: FBgn0024980
• Length: 333
• Species: Drosophila melanogaster
• Sequence 2: XP_016873680.2
• Gene: STX3 / 6809
• HGNCID: 11438
• Length: 299
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 58/256 - (22%)
• Similarity: 133/256 - (51%)
• Gaps: 11/256 - (4%)

  Fly    84 VDDILNPYTEIRQQLAQIAANLETMNRMAQTVNLRTFNE----NEMDELHNKNLRLGNQLMTRFN 144
            :|:..:...|.|..:.:|:.::|...::...:......|    :::::|..:..:..|.:..:..
Human    42 MDEFFSEIEETRLNIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLK 106

  Fly   145 DFKANLPAEND---YSLEARMKRTLFYGLHQTFINLWHKNELFLQNYETKVKKNLRLHTKIINSE 206
            ..:.::  |.|   .|.:.|::::....|.:.|:.:..|......::..:.|..::...:|...:
Human   107 SMEKHI--EEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKK 169

  Fly   207 ASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMMDRFNELRRLEKSIEEVHALFMRIQTLVM 271
            .:::|:|.::|:....:|....: :::..:|.|.|:..|..::.|||.||:|:|.:||.|..||.
Human   170 TTDEELEEMLESGNPAIFTSGII-DSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDIAMLVE 233

  Fly   272 EQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKKARKKKIMLIVILAAVLLVL-LLVGI 331
            .|.|::..:|.:......||:|..||..:|.::|.:||||.|::||::..:|.:| |::|:
Human   234 NQGEMLDNIELNVMHTVDHVEKARDETKKAVKYQSQARKKLIIIIVLVVVLLGILALIIGL 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx4	NP_525057.2	COG5074	<187..313	CDD:227406	36/125 (29%)
		SNARE_syntaxin1-like	238..298	CDD:277201	22/59 (37%)
STX3	XP_016873680.2	Syntaxin	44..236	CDD:459942	36/194 (19%)
		SNARE	204..270	CDD:473982	23/65 (35%)