Protein Alignment Syx4 and STX1A

DIOPT Version :10

• Sequence 1: NP_525057.2
• Gene: Syx4 / 31269
• FlyBaseID: FBgn0024980
• Length: 333
• Species: Drosophila melanogaster
• Sequence 2: NP_004594.1
• Gene: STX1A / 6804
• HGNCID: 11433
• Length: 288
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 67/286 - (23%)
• Similarity: 141/286 - (49%)
• Gaps: 23/286 - (8%)

  Fly    70 KDRSSSKMTQYGSN--------------VDDILNPYTEIRQQLAQIAANLETMNRMAQTV----N 116
            |||:....|...|:              :|:......|||..:.:||.|:|.:.|....:    |
Human     2 KDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPN 66

  Fly   117 LRTFNENEMDELHNKNLRLGNQLMTRFNDFKANLPAE---NDYSLEARMKRTLFYGLHQTFINLW 178
            .....:.|::||.:...:..|::.::....:.::..|   |..|.:.|:::|....|.:.|:.:.
Human    67 PDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVM 131

  Fly   179 HKNELFLQNYETKVKKNLRLHTKIINSEASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMM 243
            .:......:|..:.|..::...:|.....:.:|:|.::|:....:|....:.::...:|.|.|:.
Human   132 SEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIE 196

  Fly   244 DRFNELRRLEKSIEEVHALFMRIQTLVMEQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKKA 308
            .|.:|:.:||.||.|:|.:||.:..||..|.|:|.|:|::.:.|..:|::...:..:|.::|.||
Human   197 TRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKA 261

  Fly   309 RKKKIMLIV--ILAAVLLVLLLVGIY 332
            |:||||:|:  ::..:::...:.||:
Human   262 RRKKIMIIICCVILGIVIASTVGGIF 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx4	NP_525057.2	COG5074	<187..313	CDD:227406	35/125 (28%)
		SNARE_syntaxin1-like	238..298	CDD:277201	21/59 (36%)
STX1A	NP_004594.1	SynN	30..181	CDD:238105	28/150 (19%)
		SNARE_syntaxin1	191..259	CDD:277233	22/67 (33%)