DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2701 and ascc2

DIOPT Version :9

Sequence 1:	NP_570025.1	Gene:	CG2701 / 31261	FlyBaseID:	FBgn0024973	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_956736.1	Gene:	ascc2 / 393414	ZFINID:	ZDB-GENE-040426-1223	Length:	768	Species:	Danio rerio

Alignment Length:	824	Identity:	224/824 - (27%)
Similarity:	367/824 - (44%)	Gaps:	169/824 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LPLDELKFALS-GKDGVRRNVPALDEHWVQREKPFASYLCMLSSYGRLKSG--AALEEWTFAANN 78
            :|||||..... |..|..|.:|||  |..::|:     .|.|......:.|  |.:||:...|..
Zfish     6 VPLDELHVTEHFGPQGKERTLPAL--HPDRKEE-----RCFLPFKPPPEDGTPALVEEFLEHAQF 63

  Fly    79 FRGDMEFLLSLTQHEFWSYMVYDESAMAAVVTFLQRANPYYRQTDVSRDKELDQAHL-------- 135
            ...|:::||:|...:||..:|:|||....:.::|:.|           .:.||.:.|
Zfish    64 ISEDLDWLLALPHDKFWCQVVFDESLQGCLDSYLRHA-----------PRGLDPSGLSSSPAVAD 117

  Fly   136 LYGQLLDLVVRLIMRLCTGKESDSEWISPKQHGSLLYSNYLISVPLLFDLLIAVGDAEPENVELL 200
            :...:...:..:.:|:.|.|||...:|:|.....::|:|||..:|.:.||.:..|..   |.:||
Zfish   118 MQRNIHRSMFMVFLRMATHKESKEHFITPAVFAEIIYNNYLFDIPKILDLCVLYGKG---NSQLL 179

  Fly   201 RQIFDKVLEVQPEYQKDLKEALIFYESAF-LSMQ---IQVENEGCEGAGGGASLDVDL------- 254
            .::.|.:...||.|..||.|.:......| :.:|   ||.|:   .|||....|:.:.
Zfish   180 HKMIDNIFTQQPSYYGDLNETIPSIIQVFDIILQKCGIQSED---TGAGQPLKLNANRCLTAMTM 241

  Fly   255 -ETPYDDVVLFAMDCAYTLRLLLLLCPQLLETIEQLRLAPSIANFYDMTVPMLYKNIYLVNPGAS 318
             |....|:|.:..|...|:...|.:.|:...|.:|......:.:||:|.||.|.|.:...|...|
Zfish   242 PEEELADLVSYMCDTCTTIHSFLDIFPEACSTFKQHNFLNRLPSFYEMAVPDLEKAVKKRNFDKS 306

  Fly   319 ----SLRWLNETRQQYIFIVRRVVS---LQ--MESGRG-----QQLVEVMQECLSAQNFVVDYQR 369
                ..|.::.:|::.:.|...::.   ||  :|....     :.|::.....|..:.|:.||..
Zfish   307 LQEDMWRRVSYSRKKMVEIAHLLLQHACLQPILEGSENVASFVEDLLQNFTTFLQEKRFLADYDE 371

  Fly   370 QFPLEHDMKLLIQRCPNIKNYEVDFVVSGYQKALASC------PNGIMAD------------DMA 416
            ||||..|:.||.|..|::......:::.|.:.|..|.      |:.|.:.            |:|
Zfish   372 QFPLADDISLLQQAFPHLDETRTSYLLQGVESAWESVGKKRSFPSAISSSNHRAGAKSKTGRDLA 436

  Fly   417 SN---GVQVTGNVQDEEFKNGDSSRTSPQPSPTANGTTRDI---DLE--VTAVLEVLPDLGSGFI 473
            ::   |..|:|  ..||.:..::...:|:...  ||....:   :||  ::.:.::|||||.|||
Zfish   437 ASPTEGAGVSG--VREELRGAEAVSYTPRKGD--NGAVCTVSAGELESLLSHIRDLLPDLGEGFI 497

  Fly   474 RRLLIRYD-NSEQVIAAILDDNLPPDLAQMDRQ-----EVYIPPDPQDKQQRQTGLRHFNVHDGD 532
            ...|..|. |||.||..||:|.|.|.|.::||.     :..:||....:.         ||.|.|
Zfish   498 LACLEEYGYNSELVINNILEDKLAPSLDKLDRAMARPVKNELPPVLSTRS---------NVFDDD 553

  Fly   533 RYDVLTRDQPECI-IKQGKGLPGAPRNAEQL---LDDKRDLKQLKERYQKY-AMVEETTLERG-- 590
            .:||..||:.:.. |.:|:      |..|.:   ||||:.:::.:.|||.| .:|:|..:...
Zfish   554 EFDVFNRDRLDMSRIWKGR------RQGESVRATLDDKQHIEEQRARYQAYQTVVDEIPIANNPS 612

  Fly   591 ----------EYDDEYDDSYEAQNEGQAPPVSLLRGRLQEAASSSAYNAQDELEN---------- 635
                      :|||:|||:|:|...|                 ::..:.:|||.|
Zfish   613 GDQDNAFGLDDYDDDYDDTYDANQIG-----------------ANDLDEEDELLNRRPFTIPQVL 660

  Fly   636 ----------DDEESSGGHSDPEPSMRTNRDFCENPEVIRARYEQRQLSKYGQKSGGHGASPSVV 690
                      ||||..  ..|...:::.:. |.::|.|:|.|.|.|:.:...:|......:.:||
Zfish   661 RTSKQVQEFDDDEEED--EEDKNEAVKKDH-FIQDPAVLRERAEARRAAMQSRKGYRPPPASNVV 722

  Fly   691 GAPKGQGQSQQTQRSRGQKEAHKSTRANHNRKAGAAFKRSKGMM 734
            |.|||:||:|:|.:.|.:|||.||..|||||::.|..||:|||:
Zfish   723 GGPKGRGQTQETIQDRRRKEASKSRGANHNRRSMADRKRNKGMI 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2701	NP_570025.1	CUE_ASCC2	455..493	CDD:270547	19/40 (48%)
ascc2	NP_956736.1	CUE_ASCC2	479..518	CDD:270547	18/38 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588154
Domainoid	1	1.000	112	1.000	Domainoid score	I6151
eggNOG	1	0.900	-	-		E1_KOG4501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41774
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3539
OMA	1	1.010	-	-		QHG55054
OrthoDB	1	1.010	-	-		D311659at2759
OrthoFinder	1	1.000	-	-		FOG0007799
OrthoInspector	1	1.000	-	-		oto39271
orthoMCL	1	0.900	-	-		OOG6_105169
Panther	1	1.100	-	-	LDO	PTHR21494
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5011
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800