Protein Alignment CG2681 and Siah2

DIOPT Version :10

• Sequence 1: NP_570022.2
• Gene: CG2681 / 31258
• FlyBaseID: FBgn0024997
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_033200.2
• Gene: Siah2 / 20439
• MGIID: 108062
• Length: 325
• Species: Mus musculus
• Alignment Length: 289
• Identity: 83/289 - (28%)
• Similarity: 119/289 - (41%)
• Gaps: 42/289 - (14%)

  Fly   113 ATLPSPNVVTLRSPLSPPPKPPMLGRTRSTGPADGKGPASNGALSPDSSIIRQSFPEGVITPSKP 177
            :|.||.|....:.|  |||:.|     .:..||.....|:..|..|.||.:    |......|.|
Mouse     6 STGPSANKPCSKQP--PPPQTP-----HAPSPAAPPAAATISAAGPGSSAV----PAAAAVISGP 59

  Fly   178 EKSPATPSEEGPPTVSARHYEGLIEELRCPGCAGAMKAPILLCKSGHSVCEQCTRILLMCPLCKE 242
                  .:..|...||.:|:| |.....||.|...:..|||.|::||.||.||.:.|..||.|:.
Mouse    60 ------GAGGGADPVSPQHHE-LTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRG 117

  Fly   243 PFTNS-RSLTVEALCAKAHFRCGHASGGCQVRMPVVLLPWHEQQCMYKPMKC-FMGRVWGDCRWQ 305
            ..|.| |:|.:|.:.:...|.|.:|:.||.:.:.....|.||..|.|:|..| ..|   ..|:||
Mouse   118 ALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPG---ASCKWQ 179

  Fly   306 GREVQWKEHLEEQH--------DDRLFRSSSADL----EWNLGTRRKPLTGYYVFQAHDEMFNFY 358
            |.......||...|        :|.:|.::..:|    :|   ...:...|:: |....|....|
Mouse   180 GSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDW---VMMQSCFGHH-FMLVLEKQEKY 240

  Fly   359 EIHDRQRVLFTMTCTSNRRDSKYNFAYEV 387
            |.|.:   .|.:......|....||||.:
Mouse   241 EGHQQ---FFAIVLLIGTRKQAENFAYRL 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2681	NP_570022.2	RING_Ubox	206..250	CDD:473075	20/44 (45%)
		Sina	248..442	CDD:460824	39/153 (25%)
Siah2	NP_033200.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		13/43 (30%)
		RING-HC_SIAH2	76..126	CDD:438410	20/49 (41%)
		Sina	123..319	CDD:460824	39/154 (25%)
		SBD. /evidence=ECO:0000250|UniProtKB:P61092	131..323		36/146 (25%)