Protein Alignment PsGEF and arhgef10

DIOPT Version :10

• Sequence 1: NP_996333.4
• Gene: PsGEF / 31224
• FlyBaseID: FBgn0264598
• Length: 2777
• Species: Drosophila melanogaster
• Sequence 2: XP_009291354.2
• Gene: arhgef10 / 334278
• ZFINID: ZDB-GENE-030131-6210
• Length: 1412
• Species: Danio rerio
• Alignment Length: 1560
• Identity: 282/1560 - (18%)
• Similarity: 482/1560 - (30%)
• Gaps: 525/1560 - (33%)

  Fly   411 KLENAGNEAKRSEFLGCSTFPLNELVHPD-SGVSAGSYKLHAQACPPP--TSRHSQPKANAGQDQ 472
            :.:::|:||           |..:...|: .|:|.          |||  :|....|...|..:.
Zfish    27 EFDDSGDEA-----------PEADRPPPEPEGISV----------PPPCSSSVRDAPVNEASPNP 70

  Fly   473 KQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDP 537
            :....|..|......|.||.         .:|:|                       :::.|:..
Zfish    71 EHTFNAEADLPPPPQDFPAN---------NRPLA-----------------------EALFKQSD 103

  Fly   538 LLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNA 602
            |.|..|..|.:|...|...|..|         |:|||:|.............|...:||...|..
Zfish   104 LPPLPPPPPTELCPGAAEGRKID---------LNPPAEGTDVHRMQDENKGASVVCSSKPKVSPY 159

  Fly   603 NHLNNGTSGGR---RQSTMPNS-GGSSVGGAVRQQQG---------------------------- 635
            :.::.|....:   .||..|:| ..:.:.|.|::..|
Zfish   160 SVIDIGPIQQQLPSEQSGPPSSPSANQIEGVVQEVSGSPGLSSGYSVPVPCGYATPSNVPVIPPT 224

  Fly   636 -RTP-----FTMTKRLTRTEERGFGFSIVWTHPPRVEKIEAGLS------ADRCGILPGDYVIFV 688
             .||     |:|.:.:|...........|::....|.|.|..|:      |:...:...|.||:.
Zfish   225 YTTPVLIRHFSMDEDVTVVGAVNTPVDSVFSEECPVIKEEDALTKWVSDPANTAWMESPDEVIYD 289

  Fly   689 D----KHNVVTMPEADVLNLIR--SQGSSLTLEIFRRSGAGATTITSTDL----GQNNV------ 737
            |    .....|.|:..:.:.:.  .:|.|.:|:....|....:...::|:    |:|.:
Zfish   290 DVPRENSGSTTDPDEMIYDDVEFGEEGGSSSLDNGWSSSEFESYEENSDVENGHGENGLPDAFVR 354

  Fly   738 --------HISTRLGAAVGLGSEEH------TLATTATGTTTVMSLQRTTSTRIQPLANSMSRPA 788
                    |:|..|...     :||      .|.....||..:..|:.....::|.|..:
Zfish   355 GRAPSKKTHLSEDLARL-----KEHYERKMRDLMANTVGTVELQQLKHKHEQKMQRLVKA----- 409

  Fly   789 TACSGTTSSIEAAKRRL-------------HLPQVT-FSKES--------------IVPVTDN-- 823
             |..||...::..|..:             |..:.: |.:||              :.|..|.
Zfish   410 -AKDGTKDGLQKTKAAVRKGRSFIRTRSLCHEKKPSCFDEESDLFIEVECFNVDPVLGPAPDGLT 473

  Fly   824 -----RRRFLLQLISREQNFTAALHFGVDRFVQPLGE-RKDLISPNDHRTLFQNIDELLRIAEDI 882
                 ||..|.:::..|:::..||...::::.:||.| ...|:|....:.:|..|.|:|:.  ..
Zfish   474 QHQVMRRCILEKILESEKSYLEALKRILEQYEKPLAEIEPRLLSDRKRKVVFHRIREILQC--HA 536

  Fly   883 LEQLCSSDQQDQEPQMNFASRVYLS--KTTAICAAYKKYCN------GIKRADCVLVNKSRQTGS 939
            |.|:..:.:.....::.....|:::  ..:.:..||.:|.|      |:.|..|.    ::....
Zfish   537 LFQMALASRVSDWDELEMIGDVFVASFSKSMVLDAYSEYVNNFSLAMGVVRKACA----AKPCFL 597

  Fly   940 EFIAFITEPAVPRKRPDLTMF--IHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAA 1002
            :|:....|.:..|    ||::  :.:|:|.|.:.:.|:|.:..|..|...:.......:.||:.
Zfish   598 DFLKHRQETSKDR----LTLYGLMMKPIQRFPQFILLLQDMLKNTPVGHADRLPLQMALTELEV- 657

  Fly  1003 YREITVSSGLMEPLGEGRPLLTLQDLESRMVFTKCKPF---TLAVQGRQWIF------------G 1052
                     |.|.|.| |.....|..|.|.:.......   .|...|.:::.            .
Zfish   658 ---------LAEKLNE-RKKEADQRCEIRHIAKAMNEHYLNKLLSSGSRYLIRSDDMVETVYNDR 712

  Fly  1053 GDLSRVEGRSVKPYWTLLFSDIIVFA----KVSRDRV-------------LFITEEPIPIA---- 1096
            |::.:.:.|.|     .|.:|:::.|    :.|:|.|             .|:.:..:|::
Zfish   713 GEIIKTKERRV-----FLLNDVLMCATPNRRPSQDGVSVGAGGEGVPSGQRFLLKWSVPLSFVEV 772

  Fly  1097 -------NVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKSLI------ 1148
                   .:|||.|.......:..:...|| :|...| |....||          ::||
Zfish   773 VEFGSSEEMVDSRFPPSHSGDKVVINAKPN-KLYMGP-GQLYQDL----------QNLIHDLGLV 825

  Fly  1149 --LRAPSLELKAVWQNL-----------LQRQIFLVNAALGST--------------PLSSPLDS 1186
              :......||..:||:           |||.|......:.:.              ....|...
Zfish   826 NQISTMISSLKGNYQNVNGTVAQDWVSGLQRLILKKEEEIRAADRCRIQLQLPGKQDKYGRPTFF 890

  Fly  1187 PDVLNTLVP-LSDIGLTTASMGSMKLPSLDSIH--------------------LKQ----QQKQQ 1226
            ..|.||..| :....::...|..:.|.. |:|.                    |||    ..|.|
Zfish   891 TAVFNTFSPSIKQTWISNLQMAKLALQE-DNIQGWFCAEDDGNQMRKQNHPLLLKQMAVVMSKLQ 954

  Fly  1227 R------TNNSHGHVHSATGVATDRTAD---RSHGHNHGIHGGHVEQIELLIDEKCRILNKTGTP 1282
            .      .:|...||:      ||.|||   ..||
Zfish   955 EFKVECAVHNPEPHVN------TDSTADLPVMGHG------------------------------ 983

  Fly  1283 KSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTRQQLEKRT 1347
                   ..|: ........|..:.|:..|...|:.     .||.:|    ||...|...|::..
Zfish   984 -------CVWV-ASCTNHMGQVSIVALQNSNPKVTE-----CFNVES----RILCMTHVPLDEPL 1031

  Fly  1348 KELNLAKENGGLSARPNFGGKRLSGVEELSMSATSDIYSTS--------------EAEGVTSVIS 1398
            |.:....||......|..    ..|:||.|:|    :|.:|              :...||.::.
Zfish  1032 KNVEGKPENRNACDMPTV----CLGMEEGSIS----VYKSSQRSKKVRLQHFFSPDKSSVTCLVY 1088

  Fly  1399 QS--------------HSTTSDSQITVRSSPIVLD--------KLAVCRHCHKNCQQSGPGG--- 1438
            .|              :|.|.|. ..|.|...||.        .|.|..|.     .:..||
Zfish  1089 TSGCLYAGLVSGSLVIYSRTDDG-FWVESGACVLKLGVLPVKALLVVGEHI-----WASSGGQIF 1147

  Fly  1439 --------------------------ARPGGGGGVNNSSSTPVLLCNSLKVQHSQSSPNRCCKLS 1477
                                      ...|.|..::.|:.:.:.|.::..:.|.|.. |....::
Zfish  1148 IISTQTNTVERQFEAHQEEGMIVSHMVVAGVGIWISFSTGSTLRLFHTETLDHLQDI-NIATAVN 1211

  Fly  1478 NGIAGATEMANPK-----NSNRTGTGTGSVTSMSSSTITG--ELSSKVVAS------------SS 1523
            |.:.|...::...     .....||..|...::|...:.|  :::.:.:.|            .:
Zfish  1212 NILPGQQRVSVSSLLVCHGLLLVGTNLGVTVALSVPRLQGIPKVTGRGMVSFHAHHGPVKFLTMA 1276

  Fly  1524 RRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSL 1588
            ......:::.:|.|.:...||.|.||: :..||..|.:.|.|...||:..|      |..|..||
Zfish  1277 TAVCNVSQATMATLTSSTPSQCQPEAS-ELEGATLNQNCSRGSHAPVLQDS------PSSSCGSL 1334

  Fly  1589 PNGHCSAGVGGGSPKPLPPPRRTRVVAQMCQEPPR-PKANQQVKAIVTITETARIMRSSPTKGSG 1652
            .....|...|   |:       ...:..:..||.. .||.|          |.|:..||....||
Zfish  1335 ALSQASLEHG---PE-------DGAIYDLLNEPAHFQKAKQ----------TDRVSASSVLVVSG 1379

  Fly  1653  1652
            Zfish  1380  1379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PsGEF	NP_996333.4	DUF4799	<99..209	CDD:318308
		C2	286..>381	CDD:425499
		PDZ_canonical	645..716	CDD:483948	16/82 (20%)
		RhoGEF	835..1007	CDD:470622	36/182 (20%)
		PRK12323	<2304..>2415	CDD:481241
arhgef10	XP_009291354.2	PHA03247	<24..228	CDD:223021	46/262 (18%)
		RhoGEF	479..663	CDD:238091	41/203 (20%)
		PH_19	686..840	CDD:465965	28/170 (16%)
		WD40_2	948..1409	CDD:465964	98/527 (19%)