DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PsGEF and PsGEF

DIOPT Version :10

Sequence 1:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster
Sequence 2:XP_061507031.1 Gene:PsGEF / 3289835 VectorBaseID:AGAMI1_000312 Length:2142 Species:Anopheles gambiae


Alignment Length:2390 Identity:905/2390 - (37%)
Similarity:1200/2390 - (50%) Gaps:745/2390 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 GRRRGVGVPGVGDA--NKE--------------NFGVHFMSSPFG--NASLIALQDLSNVHGKSP 68
            ||:|.:.|..|..:  .||              :|.:.:  ||.|  |...:||:.|::.....|
Mosquito   128 GRKRALPVSPVSASFNQKEQIENIRETYATTLPSFDIEY--SPCGVKNIPFLALRGLASTEFDKP 190

  Fly    69 QRRSFSEGSGPRQ---------------------------ATP---QLAALRC------------ 91
            .|...::...|..                           .||   :::.:||            
Mosquito   191 GRYFSADEKAPTPKKIKAFVKPMLVDNFSTEFVEDNLNPCVTPLSSKMSEIRCSKTNYNRTFSTV 255

  Fly    92 --------LPR------TTGGAVALEDSQLS--SSRMGDTTLDRMLDAIIESARKEVRCTKTLPG 140
                    ||.      ::.....:|:::||  ||.|||.|||:|:|||:|||:||...|...|.
Mosquito   256 NKTANVFLLPSAPLIAPSSSDIDNIENTELSLNSSEMGDLTLDKMIDAILESAKKENHWTTQRPN 320

  Fly   141 AGATT-------------------------------------STTILADNAEWSETSVHEMEVRT 168
            ...:.                                     .||::  |.|.|:  ::|.||:|
Mosquito   321 RSLSVKSKLSKLSSPTYTPADDPAADLYLEQSLPLQMLRHDRETTMI--NEETSK--LNEREVKT 381

  Fly   169 P------------------------------------THLKRQRVVRRKN--------------- 182
            |                                    .||:||:.||||:               
Mosquito   382 PDIKHEKLCSTVINISKADYTRQSITKHIRASPLETACHLRRQKAVRRKHKLEAANNDAILYANT 446

  Fly   183 ---------------PH------KTTTINQTQS-----HQAKKLE-----------------PLQ 204
                           |:      |...||:.|:     :|.::.|                 |:.
Mosquito   447 DEYRLDNNQITSPETPYIPCSQSKFIQINEMQTPNRNDYQGQEQENPPTQFKLSDNATPDIRPID 511

  Fly   205 L----------VPSTKRCLSFSSSSASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSS 259
            |          :..:::||.||.:...:.:|       ||.|:||           ||||..|.:
Mosquito   512 LQGTSTPTGGSIEISRKCLDFSPTLGDNSID-------KRRSVAS-----------TTSSRYSRA 558

  Fly   260 SSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRDLQRSHGSG----NGSINAYVKVALSGG 320
            |:..||   .|.||::::||..: .:::|:||||||:||||:...|    |..|||||||||.  
Mosquito   559 STLTGA---CSVRGTLELSIYLE-PDRRLHVHVIRCKDLQRNCFPGSTATNNVINAYVKVALI-- 617

  Fly   321 AQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLNS 385
                ..|..:.......|:|||.|||:|..||:||||.|:|...:|   :.:|||||||||    
Mosquito   618 ----HIGDTNQTTEKELGFQRTTVHRNSNNPYYDQRFIFEIYPNDE---RRIQLAVWHRDR---- 671

  Fly   386 VPVTQSEWQARVKSGTERRTAERLAKLENAGNEAKRSEFLGCSTFPLNELVHPDSGVSAGSYKLH 450
                                            |.||||||||::||:..:...|..   |:|:|.
Mosquito   672 --------------------------------EIKRSEFLGCTSFPIKNVTVQDIN---GAYRLQ 701

  Fly   451 AQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNS 515
            .|:|      .:.|.....:...:.:|::.::....:|:.:..|.::..:....:.||:..|:|.
Mosquito   702 PQSC------LTNPTTPILETMCENSESSMEELINNEDNSSAKATSINTSTTVSLPTGAILGNNG 760

  Fly   516 AAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANS 580
            .    |.|.||                      |||||:||||||||||||||||||..|..:|:
Mosquito   761 H----NGEEIS----------------------LSKKAIHQRDADENLFLRFLELDPSPDATSNN 799

  Fly   581 TTT--QAQATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTK 643
            ...  |...|..:||.|....|..      |:|    :|.|:              ||||||:||
Mosquito   800 AIVGQQVPTTPRRSSISTCGPSKP------TAG----TTNPS--------------GRTPFTITK 840

  Fly   644 RLTRTEERGFGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQ 708
            ||||..:|||||||||||||||||||.||||||.||||||||:||||||||||||.|||||||:|
Mosquito   841 RLTRMGDRGFGFSIVWTHPPRVEKIETGLSADRAGILPGDYVVFVDKHNVVTMPEQDVLNLIRTQ 905

  Fly   709 GSSLTLEIFRR--SGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHTLAT-----TATGTTTV 766
            |::|.||||||  |.:|.             .:|.|......:.|.:.:::.     .:||..|.
Mosquito   906 GNTLLLEIFRRPQSASGP-------------QLSNRTNGVRNISSGQTSISNHGGMINSTGNITS 957

  Fly   767 MSLQRTTSTRIQ-----PLAN----SMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVP--V 820
            .::. ::|..:|     |.|:    .::|.:||||.|  |||.|||:||||||||||||||.  .
Mosquito   958 FNVS-SSSAHVQADDGEPFASPSPFGVARSSTACSNT--SIEIAKRKLHLPQVTFSKESIVQQYP 1019

  Fly   821 TDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAEDILEQ 885
            .|:||:||.|||||||:|..|::||::|||.||.|||||||||||:.||||||||.||:||||||
Mosquito  1020 DDHRRKFLYQLISREQHFINAINFGIERFVNPLRERKDLISPNDHKILFQNIDELSRISEDILEQ 1084

  Fly   886 LCSSDQQDQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAV 950
            :.   |.|.|||::|||||||||.||:||||:|||||:|:||||||||||.:..:|:.|||||.|
Mosquito  1085 II---QDDTEPQIHFASRVYLSKNTALCAAYRKYCNGLKKADCVLVNKSRNSICDFMKFITEPPV 1146

  Fly   951 PRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITVSSGLMEP 1015
            ||||||||.|||||||||||||||:|::|.:|.||:|||.||:.:|:|||.|||||||..|||||
Mosquito  1147 PRKRPDLTTFIHRPLQHFREILKLVQMIASHCRVDSEEHANFNNIISELQIAYREITVGGGLMEP 1211

  Fly  1016 LGEGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKV 1080
            :|||||||||||||:||||||||||.||..||||||||||||:||||||||||||||||::||||
Mosquito  1212 IGEGRPLLTLQDLEARMVFTKCKPFQLASHGRQWIFGGDLSRIEGRSVKPYWTLLFSDILLFAKV 1276

  Fly  1081 SRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRK 1145
            |||||||||||||.::.:.||||::|||.||||:|:|||.|..||||.:||||||||||:..:::
Mosquito  1277 SRDRVLFITEEPITLSTITDSCFNIRKKNTEFRITIDPNARQIESPTVHCAPDLTRTPKKNFKKR 1341

  Fly  1146 SLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMK 1210
            .:.|||||.||||||||||.||||||||.|||||:||||||||:|.:.:|.:|||.|..|..|:|
Mosquito  1342 YISLRAPSTELKAVWQNLLTRQIFLVNATLGSTPMSSPLDSPDILQSFLPFTDIGTTVTSAASVK 1406

  Fly  1211 LPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGGHVEQIELLIDEKCRI 1275
            :.||:|:.:|.||               :||:.                 ..::::.|||||||.
Mosquito  1407 VGSLNSMQIKNQQ---------------SGVSK-----------------VPKRVDELIDEKCRK 1439

  Fly  1276 LNKTGTPKSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTR 1340
            |||||.|:.||||||.||||||:||        |..| :.:.::.|||:      :|     |:.
Mosquito  1440 LNKTGVPQGSALHLAQWMKGQLNKQ--------IIES-DPIDSDPEQLV------ED-----WSV 1484

  Fly  1341 QQLEKRTKELNLAKENGG-LSARPNFGGKRLSGVEELSM----------SATSDIYSTSEAEGVT 1394
            :|:..|:|||||...:|. ..:.|.:.|.....:.:.:.          ||..|     :.|...
Mosquito  1485 EQVTNRSKELNLVNSDGSPFRSAPRYNGSSNGTLVKNNTINDQPFIDDNSACDD-----DDEDNK 1544

  Fly  1395 SVISQSHSTTSDSQITVRSSPI--VLDKLAVCRHCHKNCQQSGPGGARPGGGGGVNNSSSTPVLL 1457
            ||   |.||||||||||||||:  .||.:::||.|.|||:..             .||.||    
Mosquito  1545 SV---SKSTTSDSQITVRSSPLSNKLDTISMCRQCLKNCKSR-------------FNSPST---- 1589

  Fly  1458 CNSLKVQHSQ-SSPNRCCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSSTITGELSSKVVAS 1521
             |||.||.|. :|.|.|| :||...|:       :.:::...|.|::|.|:.|:.|.        
Mosquito  1590 -NSLIVQQSHCTSSNHCC-VSNSTTGS-------SLDKSINSTSSISSSSTLTMPGR-------- 1637

  Fly  1522 SSRRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVS 1586
                                                    ::||..|.|                
Mosquito  1638 ----------------------------------------QNAGCSNHV---------------- 1646

  Fly  1587 SLPNGHCSAGVGGGSPKPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGS 1651
                 .|:..:               .|.|..:       |.:.|.| :|.::.:.|..      
Mosquito  1647 -----ECAKKI---------------FVTQTAE-------NYEHKQI-SINDSYKTMCQ------ 1677

  Fly  1652 GSGSATGTGSVGGSPAKYAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESP-------------K 1703
                              .:|||:||.:||..:.||||...|:..|:||:.             |
Mosquito  1678 ------------------ISCHCKCTAKDFEKSTLSPDNCLHERVKILENACNVSSRNVSIQQVK 1724

  Fly  1704 QTTTTLE---------------------------------QKQEDEQLSLM-LIGLAQLAPAATL 1734
            |..|.:.                                 .|.:|...||| ||||||:.|.::|
Mosquito  1725 QNPTKMNGFPFNGFPFNPSLKERNAQESCIRDVYKIEDNVNKNDDTAWSLMSLIGLAQINPTSSL 1789

  Fly  1735 CGQERIPKEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSSNGGGTSTTSTATTTTKQPRQ-AI 1798
            ...:  |.|  ..|||||||||||:         :.|:||........||..:......|.. ::
Mosquito  1790 VQLD--PFE--VLPTIAVVPPTPDA---------FGNAGCIRKPMLPWTTIESNHLQLAPSTLSV 1841

  Fly  1799 IENI-----PEDSCDESPLDE--EPPYRPMSSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSF 1856
            .||.     .|.|.|.||.||  |||||.::.:|:|:||:||||::||:|        .||..:|
Mosquito  1842 TENSEVALNDEYSPDNSPEDEIVEPPYRALNPSLKRYGTISSLERVPSED--------TDDNKTF 1898

  Fly  1857 KPNGHDGNSPQNEEDDEDADSERALVQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFF 1921
                         ..|||::.:..:|..:: ..:::...:|        ||.|||       :|.
Mosquito  1899 -------------SSDEDSECDIKIVTKEV-YDNNTQTFLN--------WTARAG-------NFI 1934

  Fly  1922 EESRAFIDKYLGR---------WNAGDAQQQHQQGTASET------DEQMDECTSGATSGEEVWG 1971
            ||||||||:||||         .|..|.::..::..:..|      :|:..|..:.|||||||||
Mosquito  1935 EESRAFIDRYLGRRDNSTEEVEANNNDWEKCREKRVSEHTSSIGCDEEEAFEGETSATSGEEVWG 1999

  Fly  1972 TPTSGGDNDDQDLQLINS-ENTHSSPTKSSTSLNDDDDTELMMDELLMAPPMTASTIRGLLPRFY 2035
            ||||||:||  |:|:..| |.|||||||||:|...|||||||||||||||||||||:|||||   
Mosquito  2000 TPTSGGEND--DMQIFGSIEQTHSSPTKSSSSNTGDDDTELMMDELLMAPPMTASTVRGLLP--- 2059

  Fly  2036 RRRLEPLFEEETESDEEKTQQDSDDIKKGEATTNGHYLEDSAGSSSDSES 2085
            ||:|||||||::||.|      |||..|   ..:|.  ::.||:|...:|
Mosquito  2060 RRKLEPLFEEDSESSE------SDDDSK---PLSGR--DNQAGASYAKQS 2098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PsGEFNP_996333.4 DUF4799 <99..209 CDD:318308 49/252 (19%)
C2 286..>381 CDD:425499 47/98 (48%)
PDZ_canonical 645..716 CDD:483948 59/70 (84%)
RhoGEF 835..1007 CDD:470622 122/171 (71%)
PRK12323 <2304..>2415 CDD:481241
PsGEFXP_061507031.1 None
Blue background indicates that the domain is not in the aligned region.

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