DRSC/TRiP Functional Genomics Resources

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Protein Alignment PsGEF and LOC1271591

DIOPT Version :10

Sequence 1:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster
Sequence 2:XP_061498690.1 Gene:LOC1271591 / 1271591 VectorBaseID:AGAMI1_007425 Length:3047 Species:Anopheles gambiae


Alignment Length:3092 Identity:573/3092 - (18%)
Similarity:906/3092 - (29%) Gaps:1146/3092 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 HR-HSSSSAVVEESRGRRRG-VGVPGVGDANKENFGVHFMSSP-----FGNASLIALQDLSNVHG 65
            || .|.:......::|..|. ....|||...:..|....:|.|     |.||:          |.
Mosquito   570 HRVPSDAIGYASPTKGASRSPAAAAGVGGCGQLFFDGPLLSGPGRNRSFRNAN----------HS 624

  Fly    66 KSPQRRSFSE-GSGPRQ--------------ATPQLAALRCLPRTTGGAVALEDSQLSSSRMGDT 115
            :..|.....| |...||              ..|.:.....|| ..||:       .|.|..|..
Mosquito   625 RRLQYGQLDETGRAERQNGCVRDEIGGEALYFRPNVTRKSSLP-VLGGS-------CSYSPGGSA 681

  Fly   116 TLDRMLDAIIESARKEVR--CTKTLPGAGATTSTTILADNAEWSETSVHEMEV-RTPTHLKRQRV 177
            ...:..|||.|...:.:.  |.|.|..|..|.:............||....:. ||||       
Mosquito   682 RNLKCSDAINEIRLQSLNKYCNKLLSAATGTAAVIASPSYRGGGATSTGSTDANRTPT------- 739

  Fly   178 VRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSSSASSDLD-------EDEQQVAKRS 235
                   ...|..:||.....:||.|..:.|:      ..||...|:.       |.|.:..:|.
Mosquito   740 -------VGGTHGRTQRRPIDELEDLSFIDSS------DLSSVGDDIHINNGTDCERECRTQQRK 791

  Fly   236 SLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRDLQR 300
            ...|.....|:|.||..   :..::.:|.....|..|                       :...|
Mosquito   792 QHPSIIAGAPAHPTTPP---AVGAAGDGTRPTVADGR-----------------------KPFAR 830

  Fly   301 SHGSGNGSINAYVKVALSGGAQPPGYGGHSS---GGSMSSGYQRTAV-------HRHSGRPYFDQ 355
            ..|.|..::         |.|....|.|.||   ....|||.:..|:       ||.:.    ||
Mosquito   831 GVGVGGATV---------GFAHCNNYSGSSSDELSSVCSSGVEPLALACDSAESHRRNS----DQ 882

  Fly   356 RFNFQISSGEETAGQYLQLAVWHR---DRHLNSVPVTQSEWQARVKSGTERRTAERLAKL----- 412
            ::..|           ..|||.:|   :||.::   ...::|| ...|.:.|.|.....|     
Mosquito   883 QWQSQ-----------QPLAVKYRTQCNRHDSN---ASDDYQA-APHGEQLRVAGVGGALHTSSA 932

  Fly   413 ----------EN-----AGNEAKRSEFLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHS 462
                      ||     .|:|:.|....|.|           ||.|..:...| :......|.|.
Mosquito   933 SSSAVVCPGSENGGEVCVGSESGRLSATGGS-----------SGRSDSNNNYH-RGSSNGDSEHQ 985

  Fly   463 QPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISI 527
            |      |.|.|:....:.|.:|:..:.....:||     |.|..|.|.|.              
Mosquito   986 Q------QQQYQQQHQEQQQQQQKYTTVLSNNSAV-----KSVCVGGGVGG-------------- 1025

  Fly   528 SIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQS 592
                          :|.:|..:.::..:.|...::.:       ||:...|...|....:..|..
Mosquito  1026 --------------EPGRPGGIGEQTPYDRAVTDDCY-------PPSSSYATVRTLGYGSACSSP 1069

  Fly   593 SASKANESNAN---------HLNNGTSGGR-----RQSTM------------------PNSGGS- 624
            .:|.|..:..|         |:..|.:..|     |.:|:                  |:|||: 
Mosquito  1070 DSSPAQHAGLNCFGRSNTQFHVATGGTNDRSIMEKRNNTLDRLQRLVKKTTSSSADKQPSSGGAA 1134

  Fly   625 -SVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRVEK----IEAGLSADRCGILPGDY 684
             :.|.|.      |..|.|:||....|...|.......|||..|    :|..|......:.....
Mosquito  1135 GTSGNAA------TGATKTERLRELTELLKGNRAPPVPPPRRSKHAHSVERTLDRRNTALSTSSL 1193

  Fly   685 VIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHISTRLGAAVGL 749
            :.....|...:.||:.:|....|:    :::|..|.|.|:....||.......|....|.|.|  
Mosquito  1194 IDTGFLHGSESAPESQLLKAKESR----SVDIPYRFGDGSGQRMSTPSSPLTEHKQINLRANV-- 1252

  Fly   750 GSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTF-- 812
                                                        :||::|:.:   .||.|..  
Mosquito  1253 --------------------------------------------STSNLESLR---ELPPVVSVA 1270

  Fly   813 ---SKESIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERKDLISPNDHRTL------ 868
               .|....|..|:.   |...:||.                   |.:.::.....:|:      
Mosquito  1271 ADECKSDAGPKDDDE---LFAKLSRP-------------------ESRTIVGSYTQKTIPFRSAS 1313

  Fly   869 FQNID----ELLRIAEDILEQ--LCSSDQQDQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRAD 927
            |..:|    :.:|.|...|:.  |.|.|||.                |::.:      |.|.|..
Mosquito  1314 FSQVDYSSGKYIRSALGALKNSILKSKDQQQ----------------TSVDS------NTIPRQS 1356

  Fly   928 CVLVNKSR--------------------QTGSEFIAFITEPAVPRKRPDLTMFIHRPL----QHF 968
            |.:|..:|                    |.....:|.:|     .|:.:|.:.: .||    :::
Mosquito  1357 CKVVEAARSCSPTELRGGQVDRESQVSVQPEDTDVAKLT-----IKKTELNINL-APLDDYGRYY 1415

  Fly   969 REILKLMQLLAGNCHVDTE--------EHKNFSTVINE-----LQAAYREITVSSGLMEPL-GEG 1019
            .:.:...:.||.|.:.|.|        ||.  ..|.||     .||....:..|..::||| .||
Mosquito  1416 DDRIDGGKDLASNRNSDIETIVEDPVAEHN--ENVENEGSGVQQQANLSVMQASEMVLEPLVEEG 1478

  Fly  1020 RPLLTL---QDLESRMVFTKC-----------KPFTLAVQGRQWIFGGDLSRVE-GRSVKPYWTL 1069
            .|:...   :|.|.....|.|           ..::.|....|||   |.|..| |:        
Mosquito  1479 IPITPTSLSKDDECLQQATTCLIPVPVYDCVVSEWSTARPSEQWI---DASTTEYGK-------- 1532

  Fly  1070 LFSDIIVFAKVSRDRVL---FITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCA 1131
             |||.:...|...:..:   .:..||.|:|   :..||..|.|             .|||.....
Mosquito  1533 -FSDCLGSIKEVNENAVNEPVLAAEPEPLA---EENFHAEKIT-------------VESPPQIIE 1580

  Fly  1132 PDLTRTPKRGARRKSLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPL 1196
            |                                |..:.|.....||          |:.:|    
Mosquito  1581 P--------------------------------QESVELSEDGAGS----------DLADT---- 1599

  Fly  1197 SDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTN--NSHGHVHSATGVATDRTADRSHGHNHGIHG 1259
             :.|...:..|.|......||...:.:..:.|.  :..|..|..:.|..|              |
Mosquito  1600 -NEGSNGSDEGMMICTPPVSIICTEPESNEFTTIVDGSGSTHKVSVVLGD--------------G 1649

  Fly  1260 GHVEQIELLIDEKCRILNK-TGTPKSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQL 1323
            ..||.:|:   .|....|: .|.|::|  .|:|.:..:...:.:::|...|......:.|.:|..
Mosquito  1650 NEVEVVEV---RKRHSNNEDMGDPQNS--RLSNDVDEKRRLESRKSRRKGIYIQWPAIDANNELE 1709

  Fly  1324 IFNSDSE-----QDERITYWTRQ---QLEKRTKELNLAKENGGLSARPNFGGKRLSGVEELSMSA 1380
            ..|:||.     :|..:: |..|   |:.::...|:|:.|     :..:..||...|        
Mosquito  1710 SDNNDSAGGTAGEDVNVS-WNPQHLGQVNEKDSSLDLSGE-----SFTDLSGKDAVG-------- 1760

  Fly  1381 TSDIYSTSEAEGVTSVISQSHS--------TTSDS---------------QITVRSSPIVLDKLA 1422
                |:......|       ||        ||.||               .:|.:||....|.| 
Mosquito  1761 ----YANDRESAV-------HSPERYLLDPTTPDSDPGKPIWPKGSNRRQSLTYQSSDEKDDTL- 1813

  Fly  1423 VCRHCHKNCQQSGPGGARPGGGGGVNNSSSTPVLLCNSLKVQHSQSSPNRCCKLSNGIAGATEMA 1487
                         |..|.|      ..:..|.:|..:|:....|..:.:|....::...|.||..
Mosquito  1814 -------------PVPALP------VRTLKTLLLRSDSVSDNESDRASSRDRTSASPAPGGTEAD 1859

  Fly  1488 NPKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDD 1552
            ..:.|.|...|.               ..:::.:..::.|...:.:.   |.:|:::::|:    
Mosquito  1860 LRRYSKRPLRGP---------------YGQMLEAEMKKPTSKVQYNE---ILEELTRNESQ---- 1902

  Fly  1553 SVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSPKP----LPPPRRTRV 1613
              |..|:.:|:.|.|:..:..:..||                :|..|..|:.    ||.|...|.
Mosquito  1903 --GGNPSVARNRGAGSQSMDETNDRH----------------SGKAGSKPRKASANLPVPTHVRT 1949

  Fly  1614 VAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAKYAACHC--RC 1676
            .                              |||:|.|.|.|     |...||:|...|:.  |.
Mosquito  1950 A------------------------------SSPSKLSDSSS-----SYSASPSKRYLCNIEQRS 1979

  Fly  1677 TPEDFTHAQLS-PDKME--------HQTCKLL--------ESPKQTTTTLEQKQEDEQLSLMLIG 1724
            |..|.:...|: ..|:|        |.|.|.|        |.|.:..:......:.::.||..:.
Mosquito  1980 TDSDKSDKSLTGAGKLESKKFSFDSHLTDKSLKRGGSDVHEKPTKQRSVSSASDKQQKRSLDEVR 2044

  Fly  1725 LAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLT--------------KTSTHVWDNSGCS 1775
            |:|         ..|.|.|.:.  |:...|.||..:..              |..|......|..
Mosquito  2045 LSQ---------NSRTPSERSF--TLLNTPETPKGLAASPELLAELLKGSSEKLITEQLTGGGGG 2098

  Fly  1776 SNGGGTSTTSTAT------------TTT----------------------------KQPRQA--- 1797
            |.||..|:...|:            |.|                            |.|..|   
Mosquito  2099 SGGGRGSSGGNASNALPSAVLNCLDTRTHVVVELFNTEKSYVESLQTIVLKYLNQLKSPENAGLV 2163

  Fly  1798 -------------IIENIPE----------DSCDESPL--------------------------- 1812
                         .|.||.|          ||.|:..:                           
Mosquito  2164 DVQTVDEIFFMVPAILNIHERFLEELRRRLDSWDKMQMIGDAFVDVFSRPVILDTYTSFVNNWNR 2228

  Fly  1813 --DEEPPYRPMSSALRRF---------GTMS-------SLEKLPS-----------------DDR 1842
              |.....|....|..||         |.:|       .::|.|:                 |.:
Mosquito  2229 AKDAIRSARQKCPAFARFLEAMAREHKGKLSLDNLLIKPVQKFPNYELIFTRLIKHTDVTHPDQK 2293

  Fly  1843 -MDEADELDDDLDSFKPNGHDGNSPQNEEDDEDADSERALVQ--------NDLGASSSSGVIVNG 1898
             :.||.:|..|:..|.       :.:.:|..|:...|.||.:        |||.....:.::.:.
Mosquito  2294 PLQEALKLVHDILMFL-------NCKEKEALENGQRETALRELEGVIEGMNDLVTPERAFLLFDL 2351

  Fly  1899 EGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWNAGDAQQQHQQGTASETDEQMDECTSGA 1963
            ..:.||..|.:       :..||..:...:...:.|          :.||..:|:.   .|....
Mosquito  2352 VSMPSGQVTRK-------ERGFFLFNDLLVITSIKR----------RSGTIRKTNM---TCPGSV 2396

  Fly  1964 TS----GEEVWGTPTSGGD-----NDDQDLQLINSENTHSSPTKSSTSLNDDDDTELMMDELLMA 2019
            .|    .:..:.|..|..|     :.|::::.|..|..|         |.:|.      .:|:..
Mosquito  2397 ASTLDTNKYKYLTKISLDDLEIVKSKDENVRRIMKEIEH---------LTEDS------SKLIQI 2446

  Fly  2020 PPMTASTIRGLLPRFYRRRLEPLFEE-ETESDEEKTQQDSDDIKKGEATTNGHYLEDSAGSSSDS 2083
            ..:|||.      |.....||....| :.|...:..::.::|.:.       :.||.:..:||..
Mosquito  2447 SDLTASL------RCPHGSLEEAIRELQREIQRQLAERQTNDAQL-------NVLELTWNTSSGI 2498

  Fly  2084 ESVPPAPPLVPRPVVPDREEDPSAEGQQENLAMEDQEDLHSSVERL-LPNLATSAMGPRPLLTTR 2147
            :::         .||..:   |....|.|.:..|.::.|.:||||. :|....|.    |:..||
Mosquito  2499 QNM---------TVVFSK---PEKRTQWEEIFAEAKQKLANSVERCQIPEFFVSV----PIRKTR 2547

  Fly  2148 -------LLPTTAIDPQPPAVLVASSCEYLLDQRPSSVPGRDLAGGSIGTTTMTSSRPTPLSPAK 2205
                   ..||..:...   |.|.:|                  .|.:|...:.|..|.|     
Mosquito  2548 AGLQFTCASPTLGVQKD---VWVCNS------------------DGYVGQVCVLSLVPEP----- 2586

  Fly  2206 AAATPIGMNATMTTKTTTTTMMTPS--RAPSSTISTISSASDTTSSGGRASGRPPRFV----PPP 2264
               :....|.....:....:.:..|  |.|:|::..::.|....|.....|.||....    |..
Mosquito  2587 ---SVTSCNGVCNARILCVSSVPASEERVPNSSLLNVNIAIVDASVNSGVSNRPNNATVVSSPSK 2648

  Fly  2265 PPPRRLLLTQTDLIAGQAKTELPRKKSGATADSGCSVAVGDAAS-----ASDPTAIGSRTMPSTP 2324
            ...|:.....||..:......|....|....|||.|....||.|     ||:.:...|.::  ||
Mosquito  2649 VAERKGSFKSTDSSSSSTPRALTNNDSNVQLDSGSSSEESDAESQPERVASNQSCTTSASL--TP 2711

  Fly  2325 ------STSSLASAVAPKRPSSTII---------------------------------------- 2343
                  ||:|..:|...:...||:.                                        
Mosquito  2712 NHRQQDSTASTNAAEETENQQSTMWLGTEDGCIHVYNCTDNIRIKKNKIKIPHVSAVYSILYLDN 2776

  Fly  2344 ---------ETCLLGAPRP---ASATSSATASRMAKPI----------------------RQSPP 2374
                     :.|:....|.   .|:..:.|...::.|:                      .::..
Mosquito  2777 RVFVSLANGDICVYSRDRTGWNVSSPLTVTVGTVSNPVVKLLNVHGKLWCAIQGTIKVLNTKTLQ 2841

  Fly  2375 TQHQSQPRGQSCPAAVPAPSTAAPDAPTVPM---PHAGC------------GLSPRLEMRLALNH 2424
            ...|.|....|.|.   ...|...|...:.:   .|..|            .|:|.:...|:...
Mosquito  2842 IDSQIQISNDSKPI---TNMTVLNDYVWISVQNSAHIKCCHHESFEIIFEVNLAPSVNKMLSNCD 2903

  Fly  2425 DILGDEDLICYEPGPDLTTILG-HDLSTFHRLTGRDLLSRSATNRVQPKEAVISYSQQRNSKMDT 2488
            ||:......|..    :|::|. .||.......| .||:..|.|            ..:.|.|  
Mosquito  2904 DIIRQHKAACLR----VTSLLACKDLIWVGTSAG-VLLTIGAHN------------VAKGSSM-- 2949

  Fly  2489 PTVNRRPRPLSAGALGGSTSNSNPNNSRSS--SSHGNSPLGGGLTRAGVEPVG-------QQQLV 2544
            |.|...|.. ..|.:...|...:|:...:.  :|.|:.|.|||   ...:|.|       ||.|:
Mosquito  2950 PAVTGLPHG-HTGHVRFLTFVESPDGDSAELLASEGSVPSGGG---PSTQPGGKSNKASLQQDLL 3010

  Fly  2545 VQAGGGSAGRVGGGSG-----SAGGNSTACSSNRGGS 2576
            |         :.||.|     |||.|:.:..:.|..|
Mosquito  3011 V---------ISGGDGYEDFRSAGNNTLSEVAGREDS 3038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PsGEFNP_996333.4 DUF4799 <99..209 CDD:318308 24/112 (21%)
C2 286..>381 CDD:425499 22/107 (21%)
PDZ_canonical 645..716 CDD:483948 14/74 (19%)
RhoGEF 835..1007 CDD:470622 38/220 (17%)
PRK12323 <2304..>2415 CDD:481241 28/210 (13%)
LOC1271591XP_061498690.1 None

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