DRSC/TRiP Functional Genomics Resources

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Protein Alignment Raf and Tnni3k

DIOPT Version :10

Sequence 1:NP_525047.1 Gene:Raf / 31221 FlyBaseID:FBgn0003079 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_796040.3 Gene:Tnni3k / 435766 MGIID:2443276 Length:834 Species:Mus musculus


Alignment Length:749 Identity:184/749 - (24%)
Similarity:284/749 - (37%) Gaps:160/749 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 YLIEYQELTSKLHELEAKEQELMERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVH- 115
            |.|..:.|...|...|.:.|||.....|.:...:.||        :|:.       :|.|:.:| 
Mouse    24 YAIIIERLEDDLQIKENEFQELRHIFGSDEAFSEVSL--------NYRT-------ERGLSLLHL 73

  Fly   116 ----HGNDLTDSLGSQPGSQCGTLTRQ--PKILLRAHLPNQQRTSVEVI-----SGVRLCDA--- 166
                .||..........|.:...|||.  |.:.|..:     :.|:|:|     ||..:..|   
Mouse    74 CCACGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVY-----KDSLELITSLLHSGADVQQAGYG 133

  Fly   167 LMKALKLRQLT--PDMCEVSTTHSGR-------HIIPWHTDIGTLHVEEIFVRLLDKFPIRTHIK 222
            .:.||.:..:.  |:..||...|...       ...|.|  |...:..|....:|.||....::.
Mouse   134 GLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLH--IAAYYGHEQVTSVLLKFGADVNVS 196

  Fly   223 --------HQIIRKTFFSLVFCEGCRRLLFTG----------------FYCSQCNFRFHQRCANR 263
                    |....|.||::|      :||..|                .:||:  |..|    |.
Mouse   197 GEVGDRPLHLASAKGFFNIV------KLLVEGNKADVNAQDNEDHVPLHFCSR--FGHH----NI 249

  Fly   264 VPML------CQPFPMDSYYQLLLAENPDNG--------VGFPGRGTAVRFNMSSRSRSRRCSSS 314
            |..|      .||..::.|....|.....||        |...|..:..:.|:.|.:......:.
Mouse   250 VSYLLQSDLEVQPHVINIYGDTPLHLACYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTY 314

  Fly   315 GSS----SSSKPPSSSSGNHRQGRPP-------------RISQDDRSNSAPN--VCINNIRSVTS 360
            |.:    ......::.:.||| ||..             |:.|....|.|..  |..:..||...
Mouse   315 GKNIDLVKFLLDQNAVNINHR-GRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGE 378

  Fly   361 EVQRSLIMQA----------------RPPLPHPCTDHSNS-------TQASPTSTLKHNRPRARS 402
            :.:::.:|.|                ||....||.::|..       :..||...:|      ..
Mouse   379 KDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIK------SM 437

  Fly   403 ADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHGP-VAVKTLNVKT-PSPA 465
            ..|....||||....|  .:::...||.....|||||||.||:...... ||:|.....| .|.:
Mouse   438 TKEKADVLLLRAELPS--RFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS 500

  Fly   466 QLQAFKNEVAMLKKTRHCNILLFMG-CVSKPS-LAIVTQWCEGSSLYKHVHVSETKFKLNTLIDI 528
            .:..|..||::|.:..|..::.|:| |:..|| .|||||:..|.||:..:|..:....|.:.:.|
Mouse   501 DVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII 565

  Fly   529 GRQVAQGMDYLHA--KNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILW 591
            ...||:||:|||:  :.||||||.|:||.|:||....:.|||.:........:....|| |::.|
Mouse   566 AVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQP-GNLRW 629

  Fly   592 MAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSD 656
            |||||  ..:...|:.::||:::.:.::|||...:|:.|:........|....:..|....:...
Mouse   630 MAPEV--FTQCTRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKP 692

  Fly   657 APQALKRLAEDCIKYTPKDRPLFRPLLNMLENML 690
            ....|.|....|    |:.||.|..::..||..|
Mouse   693 ISSLLMRGWNAC----PEGRPEFSEVVRKLEECL 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RafNP_525047.1 RBD_RAF 142..212 CDD:340514 17/86 (20%)
C1_Raf 221..269 CDD:410361 15/77 (19%)
STKc_Raf 435..687 CDD:270964 83/257 (32%)
Tnni3kNP_796040.3 PTZ00322 2..>156 CDD:140343 34/151 (23%)
ANK repeat 66..98 CDD:293786 6/31 (19%)
ANK 1 66..96 6/29 (21%)
ANKYR 86..371 CDD:440430 61/304 (20%)
ANK repeat 100..131 CDD:293786 7/35 (20%)
ANK 2 100..129 7/33 (21%)
ANK 3 133..162 6/28 (21%)
ANK repeat 134..164 CDD:293786 6/29 (21%)
ANK repeat 166..197 CDD:293786 7/32 (22%)
ANK 4 166..195 7/30 (23%)
ANK repeat 199..231 CDD:293786 8/37 (22%)
ANK 5 199..229 8/35 (23%)
ANK 6 233..262 7/34 (21%)
ANK repeat 268..301 CDD:293786 6/32 (19%)
ANK 7 268..297 6/28 (21%)
ANK repeat 303..336 CDD:293786 5/33 (15%)
ANK 8 303..334 2/30 (7%)
PTZ00322 321..>428 CDD:140343 19/107 (18%)
ANK repeat 338..368 CDD:293786 4/29 (14%)
ANK 9 338..367 4/28 (14%)
ANK 10 380..409 4/28 (14%)
PKc_TNNI3K 468..721 CDD:270966 85/259 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..834
Blue background indicates that the domain is not in the aligned region.

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