DRSC/TRiP Functional Genomics Resources

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Protein Alignment Raf and MAP3K11

DIOPT Version :10

Sequence 1:NP_525047.1 Gene:Raf / 31221 FlyBaseID:FBgn0003079 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_002410.1 Gene:MAP3K11 / 4296 HGNCID:6850 Length:847 Species:Homo sapiens


Alignment Length:343 Identity:102/343 - (29%)
Similarity:153/343 - (44%) Gaps:80/343 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   410 LLLRDAK-SSEENW--------------NILA-------------EEILIGPRIGSGSFGTVYRA 446
            :|.|||. |.:|.|              |.::             :|:.:...||.|.||.|||.
Human    70 VLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRG 134

  Fly   447 HWHGP-VAVKTLNVKTPSPAQL--QAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGS 507
            .|.|. ||||...........:  ::.:.|..:.....|.||:.... |:.:|:|.:|.::..|.
Human   135 SWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGG 199

  Fly   508 SLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAK---NIIHRDLKSNNIFL--------HEDLS 561
            .|.:  .::..:...:.|::...|:|:||.|||.:   .:||||||||||.|        .|..:
Human   200 PLSR--ALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKT 262

  Fly   562 VKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLA--- 623
            :||.|||||   ..|....|.: ..|:..|||||||:   .:.:|..|||::||::::|||.   
Human   263 LKITDFGLA---REWHKTTQMS-AAGTYAWMAPEVIK---ASTFSKGSDVWSFGVLLWELLTGEV 320

  Fly   624 -----ECL--PYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRP 681
                 :||  .||...||          |..|    :.|..|:...:|..||....|..||.|..
Human   321 PYRGIDCLAVAYGVAVNK----------LTLP----IPSTCPEPFAQLMADCWAQDPHRRPDFAS 371

  Fly   682 LLNMLE----NMLRTLPK 695
            :|..||    .:||.:|:
Human   372 ILQQLEALEAQVLREMPR 389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RafNP_525047.1 RBD_RAF 142..212 CDD:340514
C1_Raf 221..269 CDD:410361
STKc_Raf 435..687 CDD:270964 88/276 (32%)
MAP3K11NP_002410.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11..38
SH3_MLK1-3 45..102 CDD:212992 8/31 (26%)
STKc_MLK3 113..379 CDD:271049 91/288 (32%)
Leucine-zipper 1 403..424
Leucine-zipper 2 438..459
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..643
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..847
Blue background indicates that the domain is not in the aligned region.

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