Protein Alignment Raf and Lrrk

DIOPT Version :10

• Sequence 1: NP_525047.1
• Gene: Raf / 31221
• FlyBaseID: FBgn0003079
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Alignment Length: 680
• Identity: 168/680 - (24%)
• Similarity: 255/680 - (37%)
• Gaps: 205/680 - (30%)

  Fly   173 LRQLTPDMCEVSTTHSGRHIIPWHTDIGTLHVEEIFVRLLDKFP-IRTHIKHQIIRKTFFSLVFC 236
            |.::.|.|.:|:             .:..|.|:.|.:.|.|.:| :.|...|.           .
  Fly  1581 LAEIRPHMSQVA-------------KLLALTVDHIDLLLEDWYPSLGTRFVHT-----------S 1621

  Fly   237 EGCRRLLFTGF-YCSQCNFRFHQRCANRVPMLCQPFPMDSYYQLLLAENPD------------NG 288
            ||  |.|.|.. .|.:|.::...:..|.        |.|.....:....|.            :|
  Fly  1622 EG--RFLITRLVLCPRCLWKLQLQQNNE--------PSDREVPPVGCNRPSRSSRRGAGAYFLHG 1676

  Fly   289 VGFPGRGTAVR-----FNMSSRSRSRRCSSS---GSSSSSKPPSSSSGNHR----QGRPPRISQD 341
            ||.||...|:.     .|.::| |.||...|   ||.:.|.....|:|:.|    .|.|.....|
  Fly  1677 VGDPGEDGALNVFSAYLNATAR-RERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPD 1740

  Fly   342 DRSNSAPNVCI-----NNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTLKHNRPRAR 401
               ||  |||.     ..|.||.::.:.|            |..|...:.|...       |...
  Fly  1741 ---NS--NVCYAWMIEECILSVYNQSKIS------------CPVHLEQSMAQLA-------PDVI 1781

  Fly   402 SADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHW-------HGPVAVKTLNV 459
            .||..:|:             .|.:|.|:.|..:|.|:||.|::|:.       ..|||:|.|..
  Fly  1782 FADIPDKH-------------TIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQP 1833

  Fly   460 KTP----SPAQLQAFK----------------------NEVAMLKKTRHCNILLFMGCVSKPSLA 498
            ..|    ..:.|.|||                      .|:|:|...:|.||:..:|...|| ||
  Fly  1834 VPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP-LA 1897

  Fly   499 IVTQWCE--G-SSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFL---- 556
            :|.:...  | .:|.:|...|......:|...:..|.|:.::|||.:.||:|||||.|:.:
  Fly  1898 LVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELP 1962

  Fly   557 --H-ED-----LSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYA 613
              | ||     :.:||.|:|: :.:|..||.|......|   :||||:||......|:.:.|.::
  Fly  1963 QPHTEDSPRNLVHIKIADYGI-SRQTAPSGAKGFGGTEG---FMAPEIIRYNGEEEYTEKVDCFS 2023

  Fly   614 FGIVMYELLAECLPY-GHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRP 677
            ||:.:||.::...|: ||.|.|:.||    .| .||.::|..:..|.....|...|....|:.||
  Fly  2024 FGMFIYENISLRQPFEGHESIKECIL----EG-SRPALTQRETQFPTCCLDLMVLCWHEQPRRRP 2083

  Fly   678 LFRPLLNMLE-----NMLRTLPKIHRSASEPNLTQS--QLQNDE----FLYLPS----------- 720
            ....::::|.     ::|..:...|.......:.||  .:.:||    .|:|||
  Fly  2084 TASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCS 2148

  Fly   721 ---------------------PKTPVNFNN 729
                                 ||||.|..|
  Fly  2149 PSGSLLQCNSISCSPQPQVAPPKTPENGAN 2178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_525047.1	RBD_RAF	142..212	CDD:340514	7/38 (18%)
		C1_Raf	221..269	CDD:410361	9/48 (19%)
		STKc_Raf	435..687	CDD:270964	87/300 (29%)
Lrrk	NP_001262772.1	ANKYR	78..>287	CDD:440430
		ANK repeat	146..177	CDD:293786
		ANK repeat	179..209	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	364..465	CDD:463710
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR	<544..>768	CDD:443914
		leucine-rich repeat	547..569	CDD:275380
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:404697
		leucine-rich repeat	855..901	CDD:275380
		LRR_4	900..941	CDD:463713
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	993..1211	CDD:476819
		COR	1230..>1393	CDD:406489
		STKc_LRRK	1801..2095	CDD:270902	88/303 (29%)