Protein Alignment Raf and ksr1a

DIOPT Version :10

• Sequence 1: NP_525047.1
• Gene: Raf / 31221
• FlyBaseID: FBgn0003079
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_001919049.4
• Gene: ksr1a / 100150814
• ZFINID: ZDB-GENE-091113-34
• Length: 970
• Species: Danio rerio
• Alignment Length: 831
• Identity: 195/831 - (23%)
• Similarity: 320/831 - (38%)
• Gaps: 237/831 - (28%)

  Fly     9 GDSDLYDPLAEELHN---------VQLVKHVTRENIDALNAKFANLQEP--------PAMYLIEY 56
            |::.:|...||.|.:         |:|..|.:...|...:.:...|:.|        ..::|:..
Zfish   232 GEAHIYHGYAESLTDPSPYYTSRPVRLHGHTSTPPITPPSRRRHRLKPPCTPPPPSRKVLHLLPN 296

  Fly    57 QELT-SKLHELEAKEQELMERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVH-HGND 119
            ..|| ||.||                    |.|..|.::.|    ..:.:::.:....|. :||.
Zfish   297 ITLTRSKSHE--------------------SQLGHRIEDTP----TNKCVKKNKLFLNVQINGNG 337

  Fly   120 LTDSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVS 184
            ..||....|.....|....|            .|:...:.|                ||.:.|
Zfish   338 CEDSPSRSPTLSVRTPGAAP------------ATAPYTLPG----------------TPTLQE-- 372

  Fly   185 TTHSG-RHIIPWH--------TDIGTLHVEEIFVRLLDKFPIRTHIKHQIIRKTFFSLVFCEGCR 240
             .||| |:.:..|        .|||..                  :.|:...|::.|.. |:.|:
Zfish   373 -EHSGLRNNVTVHRSSPQALRRDIGLA------------------VTHRFSTKSWLSQT-CQVCQ 417

  Fly   241 RLLFTGFYCSQCNFRFHQRCANRVPMLC-------------QPFPMDSYYQLLLAENP-DNGVGF 291
            :.:..|..|..|..:.|.:|....|. |             :..|.|       ..|| |.....
Zfish   418 KNMIFGVKCKHCRLKCHNKCTKEAPP-CRISFLPITKIRRTESVPSD-------INNPVDRPPEA 474

  Fly   292 PGRGT---AVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRIS----------QDDR 343
            |..||   |:.........::..|||..||::....||....:|..||.::          :|:|
Zfish   475 PQFGTLPKAITKKDQPPVLNQLDSSSNPSSTTSSTPSSPAPFQQSNPPSVTPPPNPSPKGHRDNR 539

  Fly   344 SNSA-------------PNVCINNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTLKH 395
            .:..             |:||.::|  :.|:.....:.:..|.:...   |:...:......|:.
Zfish   540 FHFPAACYFQHRQQFIFPDVCSSSI--LHSDGLPDTVNEIDPSVEEM---HAEQDEEDDREELEE 599

  Fly   396 NRPRARSADESNKNLLLRDAKSSEE---------------------------------------- 420
            .......|:|..:..:..:.:..||
Zfish   600 EEEEELEAEEDEEEEVAVEEEDEEEELEDEEDLEDLNGGSEGECEGDELDDLPSARGGHWKGPIS 664

  Fly   421 -----------NWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEV 474
                       .|:|..|::.:|..||.|.:|.|:|..|||.||::.|.:...:...|:.||.||
Zfish   665 RKASQTSVYLQEWDIPFEQLDLGELIGKGRWGRVHRGRWHGEVAIRLLEIDGNNQDHLKLFKKEV 729

  Fly   475 AMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDY 538
            ...::|||.|::|||| |::.|.|||:|.:|:|.:||..|..::....:|....|.:::.:||.|
Zfish   730 MNYRQTRHENVVLFMGACMAPPHLAIITSFCKGRTLYSVVRDTKNTLDINKTRQIAQEIVKGMGY 794

  Fly   539 LHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSG-------EKQANQPTGSILWMAPEV 596
            ||||.|:|:||||.|:| |:...|.|.||||...    ||       |.:...|.|.|.::|||:
Zfish   795 LHAKGIVHKDLKSKNVF-HDTNKVVITDFGLFGI----SGVVQEGRRENELKLPHGWICYLAPEI 854

  Fly   597 IRM------QELNPYSFQSDVYAFGIVMYELLAECLPYGHISNK--DQILFMVGRGL-LRPDMSQ 652
            :|.      ::..|:|..:||||||.:.|||.|...|   |:::  :..::.||.|. :|..:::
Zfish   855 VRKMSPGNNEDRLPFSNAADVYAFGTIWYELQARDWP---ITSQPVEATIWQVGSGEGIRRVLAE 916

  Fly   653 VRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEP 703
            :  :..:.:..:...|..|..::||.|..|.:|||.    |||::|..|.|
Zfish   917 I--NLGKEVTEILSACWSYDSRNRPTFTHLADMLEK----LPKLNRRLSHP 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_525047.1	RBD_RAF	142..212	CDD:340514	13/78 (17%)
		C1_Raf	221..269	CDD:410361	12/60 (20%)
		STKc_Raf	435..687	CDD:270964	95/268 (35%)
ksr1a	XP_001919049.4	None