DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2865 and SERTAD4

DIOPT Version :9

Sequence 1:	NP_001259184.1	Gene:	CG2865 / 31217	FlyBaseID:	FBgn0023526	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001362357.1	Gene:	SERTAD4 / 56256	HGNCID:	25236	Length:	356	Species:	Homo sapiens

Alignment Length:	335	Identity:	73/335 - (21%)
Similarity:	112/335 - (33%)	Gaps:	117/335 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DSDMFGPPR--------------CSPPIGYHHHR--------SRVPMISPKLRQREERKRILQLC 77
            ::|.:|.|.              ..||:...|:|        |::.....|..:.|:....|..|
Human    30 EADSYGGPSPPGPAQAPLQGDRGAGPPLAGSHYRGISNPITTSKITYFKRKYVEEEDFHPPLSSC 94

  Fly    78 AHK---------------MERIK---DSEANLRRSVCINNTYCRLNDELRREKQMRYLQN---LP 121
            :||               :|::|   |.|..|||||.|||...|::.|:       .:||   .|
Human    95 SHKTISIFEERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEI-------IMQNNWCFP 152

  Fly   122 RTSDSGASTE---LARENLFQPNMDDAK-------------PAGNSTSN---NINAN-GKPSSSF 166
            ..|.:|.|.:   :|::..::.....||             ..|....|   ::||| |..|::.
Human   153 ACSFNGTSAQEWFMAQDCPYRKRPRMAKEECEKFHACCFYQECGGHYLNLPLSVNANVGSASTAA 217

  Fly   167 GDAFGSSNGSSSGRGGICSLENQPPERQQLGTPAGASAPEAANSAPLSVSGSASERVNNRKRHLS 231
            .....||:.|||        .:.||          ...|..:......| ||||
Human   218 SSPSASSSSSSS--------SSSPP----------LPLPSCSRQVDFDV-GSAS----------- 252

  Fly   232 SCNLVNDLEILDRELSAINAPMLLIDPEITQGAEQLEKAALSASRKRLRSNS-----GSEDESDR 291
              ...:|.:|...|:...|...|.:.          |||.|:..:....:|.     ..|...:.
Human   253 --IYKSDGQIPANEIFVTNVRSLGVQ----------EKAKLNDEKANDDTNRDGGPLSHEPVGND 305

  Fly   292 LVREALSQFY 301
            |..|...|||
Human   306 LAFECKGQFY 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2865	NP_001259184.1	SERTA	73..109	CDD:283648	18/53 (34%)
SERTAD4	NP_001362357.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..53		2/19 (11%)
		SERTA	108..142	CDD:368713	13/33 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..238		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..302		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2E2MX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830