DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3078 and UNC93B1

DIOPT Version :9

Sequence 1:	NP_001356930.1	Gene:	CG3078 / 31211	FlyBaseID:	FBgn0023524	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_112192.2	Gene:	UNC93B1 / 81622	HGNCID:	13481	Length:	597	Species:	Homo sapiens

Alignment Length:	521	Identity:	107/521 - (20%)
Similarity:	189/521 - (36%)	Gaps:	120/521 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 LAHGLMNCVLLPVMALQGSNAVWHHREEWLPLG------PEVGSLLLSALFLVAAGMSLPSIRLM 315
            |.:|    |.|.::.:|   .:.|:.|.:..:.      |::.|.:|       .|:::..|..:
Human    73 LTYG----VYLGLLQMQ---LILHYDETYREVKYGNMGLPDIDSKML-------MGINVTPIAAL 123

  Fly   316 KRYGYGPLIVANYMTV-LLFLLSHLYA---------SIYTLLPAYLLLGMTLSGSAGSKAALIVH 370
            .   |.|:::..:.|. ::||...:||         ..|||:|:.:.|||.:.....|....|..
Human   124 L---YTPVLIRFFGTKWMMFLAVGIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITR 185

  Fly   371 FGGKLSCSCDSQQSQAAVDVLHEEHKMFCNRDQKVRRLARWFRVSQDLGLIGGALLASILLACSD 435
            ...|                 :.|:..:..:|      .:..:.....|.....||....:..|.
Human   186 MAQK-----------------YHEYSHYKEQD------GQGMKQRPPRGSHAPYLLVFQAIFYSF 227

  Fly   436 GNFTGDCSGL--VYYGNESWPPQLRDFYNRNEHGDRICGADMCPLRVQSILEAGWANGSSIPSSI 498
            .:.:..|:.|  :|:.|.    .|.|. |...:..:.||                .|...|.|..
Human   228 FHLSFACAQLPMIYFLNH----YLYDL-NHTLYNVQSCG----------------TNSHGILSGF 271

  Fly   499 YAGFIESEPRVAGQSLLWLYVLFSMVSLTLSLLIVVDKVQAIGSSRPERSRDV-SITDTLLFAGP 562
            ....:.:.|| :|..::...||  |....|::|:|:....|  :.||....|: |:....:|..|
Human   272 NKTVLRTLPR-SGNLIVVESVL--MAVAFLAMLLVLGLCGA--AYRPTEEIDLRSVGWGNIFQLP 331

  Fly   563 ------------LAYFV--GTEQAYMMGDFLRAFVTCSLGIGMIAGALIGMGLMQLIVSCTLSML 613
                        :.:|:  |.|..:........:..||:|:..:|..|:...|.....| .|.:|
Human   332 FKHVRDYRLRHLVPFFIYSGFEVLFACTGIALGYGVCSVGLERLAYLLVAYSLGASAAS-LLGLL 395

  Fly   614 LRHVKRIVVILAGFFFHSCLLLALSSWKPSS---DDSALFYVIAASWGACNGMWETLLLSLVTLN 675
            ...:.|.|.::||...|..|...|..|.|..   ..|.:.||.||.||..:.:.:|.|.:|:.:.
Human   396 GLWLPRPVPLVAGAGVHLLLTFILFFWAPVPRVLQHSWILYVAAALWGVGSALNKTGLSTLLGIL 460

  Fly   676 HSSHVTE---------VQAPLLALRFLGLGLTFAGHGFLCESMKIIALVVLLVISVPPYATLEIR 731
            :.....:         .||..:...:||..|..        ..|:..|:|.||.:...|..:|.:
Human   461 YEDKERQDFIFTIYHWWQAVAIFTVYLGSSLHM--------KAKLAVLLVTLVAAAVSYLRMEQK 517

  Fly   732 L 732
            |
Human   518 L 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3078	NP_001356930.1	bZIP	<11..>43	CDD:354818
CG3078	NP_001356930.1	MFS	<496..731	CDD:355786	60/261 (23%)
UNC93B1	NP_112192.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		MFS_unc93B1	64..520	CDD:340966	107/521 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..597
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3097
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700