DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3078 and unc-93

DIOPT Version :9

Sequence 1:	NP_001356930.1	Gene:	CG3078 / 31211	FlyBaseID:	FBgn0023524	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001021218.1	Gene:	unc-93 / 175466	WormBaseID:	WBGene00006822	Length:	705	Species:	Caenorhabditis elegans

Alignment Length:	561	Identity:	111/561 - (19%)
Similarity:	211/561 - (37%)	Gaps:	142/561 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 AALAASRRRESINSSIGATSIRRLITLNNRNCRHKVPAHVRQKVWRQFSCLSLA--------HGL 261
            |.|...::||.::.:             .:...:|:...:...:|    .||:|        :||
Worm   220 AKLVRKKKREMMSGT-------------EKERANKIKRKIMSNLW----ILSVAFLFLFTAFNGL 267

  Fly   262 MNCVLLPVMALQGSNAVWHHREEWLPLGPEVGSLLLSALFLVAAGMSL--PSIRLMKRYGYGPLI 324
            .|        ||.|            :..::||..|.||:|..|..||  ||. ::.|.|.....
Worm   268 QN--------LQTS------------VNGDLGSDSLVALYLSLAISSLFVPSF-MINRLGCKLTF 311

  Fly   325 VANYMTVLLFLLSHLYASIYTLLPAYLLLGMTLSGSAGSKAALIVHFGGKLSCSCDSQQSQAAVD 389
            :.......|:::.:|..:..:::||.:..|:..|...|:|.|.|...|  :..:..:.:||..|.
Worm   312 LIAIFVYFLYIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMG--IRYASLNFESQTTVI 374

  Fly   390 VLHEEHKMFCNRDQKVRRLARWFRVSQDLGLIGGALLASILLACSDGNFTGDCSGLVYYGNESWP 454
            |                |...:|.:....|.:.|.:::|.:...|
Worm   375 V----------------RFFGYFFMIVHCGQVVGNMVSSYIFTLS-------------------- 403

  Fly   455 PQLRDFYNRNEHGDRICGADMC----PLRVQSILEAGWANGSSIPSSIYAGFIESEPRVAGQSLL 515
                  |::...|......|.|    |..:..:.|...:|.:..|..:|..       |....|.
Worm   404 ------YSQALRGPEDSIYDSCGYQFPKNLSDLTELAESNLARPPQKVYVA-------VCLAYLA 455

  Fly   516 WLYVLFSMVSLTLSLLIVVDKVQAIGSSRPERSRDVS---------------ITDTLLFAGPLAY 565
            .:.:...::|:.|:.|           ::..|:|.::               |....:...||..
Worm   456 CVIISGMIMSMFLNAL-----------AKDARNRKMAQKFNSEIFYLMLKHLINIKFMLLVPLTI 509

  Fly   566 FVGTEQAYMMGDFLRAFVTCSLGIGMIAGALIGMGLMQLIVSCTLSMLLRHVKRIVVILAGFFFH 630
            |.|.|||:::|.:.:|||.|.|||..|...:...|:...:.|.....|::...|:.:.:.|...:
Worm   510 FNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVN 574

  Fly   631 SCLLLALSSWKPSSDDSALFYVIAASWGACNGMWETLL----LSLVTLNHSSHVTEVQAPLLALR 691
            ..:::.|..|..::.|:.:|||:||.||..:|:|.|.:    ::||...      .:|......|
Worm   575 LLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALVGRQ------SLQFAFTKYR 633

  Fly   692 F---LGLGLTFAGHGFLCESMKIIALVVLLVISVPPYATLE 729
            |   ||:.:.||....:...:.::....:|::.:..:..:|
Worm   634 FWESLGIAIGFALIRHVTVEIYLLITFFMLLLGMCGFLAIE 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3078	NP_001356930.1	bZIP	<11..>43	CDD:354818
CG3078	NP_001356930.1	MFS	<496..731	CDD:355786	54/256 (21%)
unc-93	NP_001021218.1	MFS	250..673	CDD:119392	105/515 (20%)
unc-93	NP_001021218.1	MFS_1	250..643	CDD:284993	102/485 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4703
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960