Protein Alignment Vinc and CTNNAL1

DIOPT Version :10

• Sequence 1: NP_476820.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_003789.1
• Gene: CTNNAL1 / 8727
• HGNCID: 2512
• Length: 734
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 139/712 - (19%)
• Similarity: 269/712 - (37%)
• Gaps: 138/712 - (19%)

  Fly     6 TKTIESILDPVAQQVSRLVILHEE--AEDGNAMPDLSRPVQVVSAAVANLVKVGRDTINSSDDKI 68
            |:::|..|.|:..|::.| |.|::  .:....:..:.|..|.|:.||...||||....|.:.|
Human    34 TRSVEQTLLPLVSQITTL-INHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENWD-- 95

  Fly    69 LRQDMPSALHRVEGASQLLEEASDM-----LRSDPYSGPARKK--LIEGSRGILQGTSSLLLCFD 126
            |::::..|....:.|.:.:...:|:     |.||........|  :|:.:|.:|...:.:||..|
Human    96 LKEEINIACIEAKQAGETIAALTDITNLNHLESDGQITIFTDKTGVIKAARLLLSSVTKVLLLAD 160

  Fly   127 ESEVRKIIQECKRVLDYLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEILV 191
            ...:::||....:||..:...|.:|:.::.||........:.:.....|.|:.:|..:.....:.
Human   161 RVVIKQIITSRNKVLATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKKAKMA 225

  Fly   192 RCLEQVKTLAPILICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRVLQ--LTTYDE 254
            .....::....:|:.:.|..:     :....|.|.:|:..:..||...|.::|.::.  ....:.
Human   226 AARAVLEKCTMMLLTASKTCL-----RHPNCESAHKNKEGVFDRMKVALDKVIEIVTDCKPNGET 285

  Fly   255 DTSELDNLTVLKKLSNAI----SNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEISERCLPQ 315
            |.|.:...|.:|:....|    .|...|:.|.||           ..|..:::...:.::.....
Human   286 DISSISIFTGIKEFKMNIEALRENLYFQSKENLS-----------VTLEVILERMEDFTDSAYTS 339

  Fly   316 DSYPIRKLADEVTAMANTLCELRQ--------EGKGQSPQAESL---VRGIRDRMGELKSLVHQA 369
            ..:..|.|  |::..|.  .||:|        :.|.....||.|   :..|...:.|||..:|
Human   340 HEHRERIL--ELSTQAR--MELQQLISVWIQAQSKKTKSIAEELELSILKISHSLNELKKELH-- 398

  Fly   370 VLGVDKAGVQQTAHTIQGRLEQAV-KWLQHPEINDGGLGERAINLIVEEGRKVAEGCPGHQKAEI 433
                 ....|..|..::...:..| |.|:...:      |..:..:.|...|::|     ||.::
Human   399 -----STATQLAADLLKYHADHVVLKALKLTGV------EGNLEALAEYACKLSE-----QKEQL 447

  Fly   434 QQLCDEVERLKRQAAGSGPA------AKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDV----- 487
            .:.|    ||.|..:|:.|.      |::..:...|::......:.....::|.::.:||
Human   448 VETC----RLLRHISGTEPLEITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAW 508

  Fly   488 -------STPLKQFTEAVLQPEGTPGREQNF----NQKSNNLQAFSDRASKTSRMVAAGGACGNK 541
                   ||.|::..:..   ||..|.:..:    ....||....|.:..|......|
Human   509 ESQISDMSTLLREINDVF---EGRRGEKYGYLSLPKPMKNNANLKSLKPDKPDSEEQA------- 563

  Fly   542 KIAEILLSSAAQVDSLTPQLISAGRIRMNYPGSKAADEHLQNLKQQYADTVLRMRTLCDQA---- 602
            |||::.|    ::..||..                ||..::..:.|..:.|...|.:...|
Human   564 KIAKLGL----KLGLLTSD----------------ADCEIEKWEDQENEIVQYGRNMSSMAYSLY 608

  Fly   603 --TDPADFIKTSEE---HMQVYA----KLCEDAIHARQPQKMVDNTSNIARLINRVLLVAKQ 655
              |.....:|||::   .::|:|    || ..::.|...|...|:...:...||:::.:..|
Human   609 LFTRGEGPLKTSQDLIHQLEVFAAEGLKL-TSSVQAFSKQLKDDDKLMLLLEINKLIPLCHQ 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_476820.1	Vinculin	3..960	CDD:460040	139/712 (20%)
CTNNAL1	NP_003789.1	Vinculin	31..675	CDD:460040	139/712 (20%)