Protein Alignment Vinc and Vinac1

DIOPT Version :10

• Sequence 1: NP_476820.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: XP_001004454.2
• Gene: Vinac1 / 668894
• MGIID: 3649276
• Length: 1413
• Species: Mus musculus
• Alignment Length: 1427
• Identity: 272/1427 - (19%)
• Similarity: 452/1427 - (31%)
• Gaps: 550/1427 - (38%)

  Fly     2 PVFHTKTIESILDPVAQQVSRLVILHEEAEDGN-AMPDLSRPVQVVSAAVANLVKVGRDTINSSD 65
            |....:.:|.|:.|:..|:..|:|..|..|..| |:..|.:..:.::.|....|.|.......|:
Mouse    13 PTIQNRAMEQIITPMTVQLCHLLISVERKEVQNKALASLQKVAEQLANASEEFVHVASRLAGDSE 77

  Fly    66 DKILRQDM-PSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESE 129
            :|.||::| |.|...:.....:|..| :.|...|.|....::|:..::.:|..|..:||..|.:.
Mouse    78 EKWLREEMKPVAESLILSGRNILRVA-EKLHLQPESQRHWEELVATAQQVLVDTKKVLLLDDAAA 141

  Fly   130 VRKIIQECKRVLDYLAVAEVINTMEQLVQFLKDLSPCLSKV-----------------HR----- 172
            |||........|..:...|.......|...|.||:..|.::                 ||
Mouse   142 VRKTRTAANWCLTCVEALEEAEDTTSLRTSLDDLAAALFRLGGLTARWAWDQHLGRARHRLGCCV 206

  Fly   173 ------------------EVGAREK--ELTHQVHSEIL-----------VRCLEQVKTLAPILIC 206
                              .|.:|.:  .||.|...|:|           ...|.|...||..| |
Mouse   207 PALLAAAHGHLRHPRDPQLVASRRRVFALTRQSLEELLDALQPGVGVVGTGVLSQNGALARGL-C 270

  Fly   207 SMKVYIHIVEQQGRG-------------------AEEAAENRNYLAARMSDELQEIIRVLQLTTY 252
            .::   .::|..|.|                   |..|.:.|.:|.:|....:|....|..|...
Mouse   271 KLR---KVLEDPGPGHLLLDAPLAAVVWHCLRLAACSAPQERMHLVSRCRQLMQLRPGVHSLPRS 332

  Fly   253 DEDTSELDNLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKALRQVIDNATE---------- 307
            ...|    :...|:..::|:..             |:|.|:    |||::|..|:
Mouse   333 SPGT----DCEALRAATDALFR-------------AVRAGL----LRQILDTFTDTQSPLETLVQ 376

  Fly   308 -------ISERCLPQDSYPIRKLADEVTAMANTL-----------------CELRQEGKGQSPQA 348
                   |..||   ||   ..||:.|..:.:..                 |..:|.|:    ..
Mouse   377 AALATSTIRFRC---DS---EALAETVQILLDAFHNQAKQMIRVAHLVWVCCPQQQTGR----DL 431

  Fly   349 ESLVRGIRDRMGELKSLVHQA--VLGVDKAGVQQTAHTIQGRLEQAVKWLQH-----------PE 400
            |:.|.|::..:.::|.|..|:  .||:|     .:..|:|..||...:..:|           ||
Mouse   432 EAAVAGLQRLVIKVKELFSQSPQTLGLD-----WSPATLQALLEAWARESEHLLSCFDVVLNIPE 491

  Fly   401 INDGGLGERAINLIV-----------EEGRKVA--EGCPGH--------------------QKAE 432
            .....:.|...:|.:           |..|.||  .|...|                    .:..
Mouse   492 FLSVSIQEMTKHLDLSTIALRSGASREFSRSVAFLRGRATHIVQVMSRYVGQDPDPIFRNGMRVV 556

  Fly   433 IQQLCDEVERLKRQAAGSGPAAKQAAKQ----LTQKLYELKAAIQNALVNRIVQDFM------DV 487
            :|||......|  .||..|..|:.:|:.    ||...:.:.||.|       |::.:      |:
Mouse   557 VQQLAQSSVTL--GAATEGSRAEDSAQDTDVFLTMAKHLIHAAQQ-------VREGLDGSNHPDI 612

  Fly   488 STPLK----QF-----------------TEAVLQPEGTPG------------------------- 506
            .:||:    :|                 |.:.::.:..||
Mouse   613 LSPLRVQVQRFDMTKGWSYFILPSPQHPTASEIKYQRVPGLWKSGPNTSLLPVEQLSYTVVPGTC 677

  Fly   507 ----------------REQNFNQKSNNLQAFSDRASKTSRMVAAGGACGNKKIAEILLSSAAQVD 555
                            ..:|.|.:...|...:.....::.........|.:.:....::...:|.
Mouse   678 IHGWRFPLPAVSKGVTTMENRNHQVVTLPCTNTPEQNSTVDTVQETQAGEETLGPERMTGLQEVS 742

  Fly   556 SLTPQLISAGR-------------IRMNY------------------------------------ 571
            :|.|.:|...|             :|:::
Mouse   743 TLAPSIIDLARKEVHSANTGSEELLRVSFQQSQGTREDRWGLVARAGDWYPLCQQLFCHNLETEL 807

  Fly   572 PGSKAADEHLQ----------------NLKQQYADTVLRMRTLCDQATDPADFIKTSEEHMQVYA 620
            |||.||...||                |:.::..|.:...|.|.:        ::...|..:::|
Mouse   808 PGSMAAFVELQQDLALMVQVAAKSGPVNVDKKNPDLMGHPRLLLE--------LQDRSEKTEIHA 864

  Fly   621 KLCEDAIHA----RQPQKMVDNTSN------------------IARLINRVLLVAKQEADNSED- 662
            |...|.:.:    ::|....:|..|                  .:|.....||..:|...|.:.
Mouse   865 KQLLDQVLSSDGLQEPTLREENIDNGCLLWAVAVQDLMQCMERFSRRQGLFLLPLRQAVKNQQGL 929

  Fly   663 -------PVFTERLNAAANRLERSLPAMVGDAKL------------VATN---------IADP-- 697
                   ...::||..||    :....:.|||::            |.|:         ::.|
Mouse   930 QKGLGQAAEISQRLQEAA----KLSSVLCGDAQVKGEISFLCREVHVLTDALLEVAHILVSSPKP 990

  Fly   698 ---------------------------AAAAAWKNSFQ------------RLLGDVREVRDAIAP 723
                                       :..||:::.||            .:|..::.|:..||.
Mouse   991 CPSLSTRFELLCLELSLRAKALTDYLTSINAAYEHMFQDVISKSSQNRIEGMLSTIQAVQGIIAG 1055

  Fly   724 PQ-----PPPLPTSLP-------------PPIPELSALHL------------------------S 746
            .|     ...|..||.             |.:.|:.:||.                        |
Mouse  1056 GQESETVQKDLLVSLESILTLTKEVVRKVPVLQEVQSLHTLDWLQWEWAAKVHHAVTQLQALEGS 1120

  Fly   747 NQNA------------ERAPP-------RPPLPREGLAPVR---------PPPPETDDEDEGVFR 783
            :..|            |:|.|       .||...||.|...         ..|.:|.:...|...
Mouse  1121 HMEAWRLLVQYLKPRGEQAKPLEEDLVQPPPHCNEGTAGTTSGVSVDSQGAVPKDTPESSVGTCA 1185

  Fly   784 TMPHANQPILIAARGLHQE-------------VRQWSSKD--NEIIAAAKRMA---ILMARLSEL 830
            ..| |......|.|.:||.             ..:.||.|  |.|....:.||   :||||  .|
Mouse  1186 DEP-ATTRTTTADRSMHQSGSLSLPPAQMDQPAPEDSSADSENRITQITQEMATEVLLMAR--SL 1247

  Fly   831 VLSDSRGSKRELIATAKKIAEASEDVTRLAKELARQCTDRRIRTNLLQVCERIPTIGTQLKILST 895
            ..|....:|.:|||:|:|::.:.:|.|||...:|:.|.|:|....||.:.|:|.|:.:||.|:|:
Mouse  1248 RKSGQVLTKDQLIASARKVSASGKDFTRLIHIIAKNCIDQRCSQELLCMVEQIQTMSSQLSIISS 1312

  Fly   896 VKATMLGAQGSDEDREATEMLVGNAQNLMQSVKETVRAAEGASIKIRSDQTSNRLQWVRRQP 957
            |||::..::.|:      |:||.|||.|:|:|.:||.|.|.|.::        .|:|....|
Mouse  1313 VKASLTRSKSSE------ELLVDNAQRLLQAVSKTVSAVEAACLR--------GLRWPSSDP 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_476820.1	Vinculin	3..960	CDD:460040	271/1426 (19%)
Vinac1	XP_001004454.2	Vinculin	15..>610	CDD:460040	129/644 (20%)
		Vinculin	<1224..1375	CDD:460040	55/153 (36%)