Protein Alignment Vinc and Ctnna1

DIOPT Version :10

• Sequence 1: NP_476820.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_001007146.1
• Gene: Ctnna1 / 307505
• RGDID: 1359485
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 1008
• Identity: 229/1008 - (22%)
• Similarity: 401/1008 - (39%)
• Gaps: 219/1008 - (21%)

  Fly     6 TKTIESILDPVAQQVSRLVILHEEAEDGNAMPDLSRPVQVVSAAV----ANLVKVGRDTINSSDD 66
            |..:|.:|:|:..||:.||..:.:. ..|.....|:...|::|:|    .|.::.| |.| :.:.
  Rat    22 TLAVERLLEPLVTQVTTLVNTNSKG-PSNKKRGRSKKAHVLAASVEQATENFLEKG-DKI-AKES 83

  Fly    67 KILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESEVR 131
            :.|::::.:|:..|.....|::.|:.....||.|...|..::..:|.:|...:.||:..|.::|.
  Rat    84 QFLKEELVAAVDDVRKQGDLMKSAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVY 148

  Fly   132 KIIQECKRVLD-YLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEILVRCLE 195
            |::.:.|.|.| .|.:....|..:..:|: :.|.|.:.|::.....|::||....|.:.:.....
  Rat   149 KLLVQLKVVEDGILKLRNAGNEQDLGIQY-RALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARG 212

  Fly   196 QVKTLAPILICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRVLQLTTYDEDTSELD 260
            .::...|||..:.:.   .::.....|.:|  ||:.:..::...:..|....|.|..| |.|:
  Rat   213 ILQKNVPILYTASQA---CLQHPDVAAYKA--NRDLIYKQLQQAVTGISNAAQATASD-DASQ-- 269

  Fly   261 NLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKAL------RQVIDNATEISERCLPQDSYP 319
                            :|..         .||.||.|.      :|:|.:....||
  Rat   270 ----------------QQGG---------GGGGGELAYALNNFDKQIIVDPLSFSE--------- 300

  Fly   320 IRKLADEVTAMANTLCELRQEGKGQSPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQQTAHT 384
                                         |.....:.:|   |:|::..|.|..|      ::.|
  Rat   301 -----------------------------ERFRPSLEER---LESIISGAALMAD------SSCT 327

  Fly   385 IQGRLEQAVKWLQHPEINDGGLGERAINLIVEEGRKVAEGCPGHQKAEIQQLCDE----VERLKR 445
            ...|.|                            |.||| |...::| :|.|..|    ..|.:|
  Rat   328 RDDRRE----------------------------RIVAE-CNAVRQA-LQDLLSEYMGNAGRKER 362

  Fly   446 QAAGSGPAAKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGREQN 510
                 ..|...|..::|:|..:|:..::.|:::.:...|::.:.||....||.          :|
  Rat   363 -----SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAA----------KN 412

  Fly   511 FNQK--SNNLQAFSDRASKTSRMVAAGGAC---GNKKIAEILLSSAAQVDSLTPQLISAGRIRMN 570
            .|:|  ....|.|.:.|:|.  :..|..||   .|::..:::..||:|:::|.||:|:|......
  Rat   413 GNEKEVKEYAQVFREHANKL--IEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAA 475

  Fly   571 YPGSKAADEHLQNLKQQYADTVLRMRTLCDQATDPADFIKTSEEHMQVYAKLCEDAIHARQPQKM 635
            .|.||.|.|::...|:|:...|..:....|..|...||:..||.|:......|..|:.    :|.
  Rat   476 KPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQ----EKD 536

  Fly   636 VDNTSNIARLIN----RVLLVAKQEADNSEDPVFTERLNAAANRLERS-LPAMVGDAKLVATNIA 695
            ||.....|..|.    ||:.|...|.||.|..|:||::..|...|..: :|......:.....::
  Rat   537 VDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALS 601

  Fly   696 DPAAAAAWKNSF---QRLLGD-VREVRDAIAPPQPPP---------------LPTSLPPPIPELS 741
            ...|....:|.|   .||:.| :|::|.|:...:.|.               ..||:.....:|
  Rat   602 SDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQL- 665

  Fly   742 ALHLSNQNAERAPPRPPLPREGLAPVRPPPPETDDEDEGVFRTMPHANQPILIAARGLHQEVRQW 806
               ::.|:|.....:  ||:|..|.:........:|..                  .|..||.:|
  Rat   666 ---IAGQSARAIMAQ--LPQEQKAKIAEQVASFQEEKS------------------KLDAEVSKW 707

  Fly   807 SSKDNEIIAAAKRMAILMARLSELVLSDSRG-----SKRELIATAKKIAEASEDVTRLAKELARQ 866
            ....|:||..||:|.::|..:::.    :||     :..::|:.|||||||...:.:|.:.:|..
  Rat   708 DDSGNDIIVLAKQMCMIMMEMTDF----TRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADH 768

  Fly   867 CTDRRIRTNLLQVCERIPTIGTQLKILSTVKATM--LGAQGSDEDREATEMLVGNAQNLMQSVKE 929
            |.|...:.:||...:||.....||.|.|.|||.:  ||.:......::...|:..|:|||.:|.:
  Rat   769 CPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQ 833

  Fly   930 TVRAAEGASIKIRSDQTSNRL-----QWVRRQP 957
            ||:|:..||.|.:..|....|     .|..:.|
  Rat   834 TVKASYVASTKYQKSQGMASLNLPAVSWKMKAP 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_476820.1	Vinculin	3..960	CDD:460040	229/1008 (23%)
Ctnna1	NP_001007146.1	Vinculin	19..869	CDD:460040	229/1008 (23%)