Protein Alignment Vinc and CTNNA3

DIOPT Version :10

• Sequence 1: NP_476820.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: XP_016871641.1
• Gene: CTNNA3 / 29119
• HGNCID: 2511
• Length: 970
• Species: Homo sapiens
• Alignment Length: 1027
• Identity: 213/1027 - (20%)
• Similarity: 397/1027 - (38%)
• Gaps: 242/1027 - (23%)

  Fly     6 TKTIESILDPVAQQVSRLVILHEEAEDGNAMPDLSRPVQVVSAAVA----NLVKVGRDTINSSDD 66
            |.|:|.:|:|:..||:.||...:  ...:.....|:...|:.|:|.    ||:..|...  :.:.
Human    32 TFTVEKLLEPLIIQVTTLVNCPQ--NPSSRKKGRSKRASVLLASVEEATWNLLDKGEKI--AQEA 92

  Fly    67 KILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESEVR 131
            .:|:.::.::|..|...|:.|:.:::....||...|.|:.:::.:|.:|...:.||:..|
Human    93 TVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLILAD----- 152

  Fly   132 KIIQECKRVLDYLAVAEVINTMEQLVQFLKDLS--PCLSKVHREVGAREKELTH------QVHS- 187
                    ::|.:.:.:.::..::..:.||:::  ..|.|.::::|...:.|.:      ||::
Human   153 --------MIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQVNNS 209

  Fly   188 ---------------------------EILVRCLEQVKTLAPIL--ICSMKVYIHIVEQQGRGAE 223
                                       :.:......:|..:|:|  |||.     .:|.....:.
Human   210 GLNTTFAFSRKNLPTPKASDLKSPNQRDEIAGARASLKENSPLLHSICSA-----CLEHSDVASL 269

  Fly   224 EAAENRNYLAARMSDELQEIIRVL----------------QLTTYDEDTSELDNLTVLKKLSNAI 272
            :|:::      .:.:|:|..:.|:                |..|......||:||.||    |.:
Human   270 KASKD------TVCEEIQNALNVISNASQGIQNMTTPPEPQAATLGSALDELENLIVL----NPL 324

  Fly   273 SNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEISERCLPQDSYPIRKLADEVTAMANTLCEL 337
            :...|:....|           ||.|..:|..|..:::....:|.:..|.:| |..|:...|.:|
Human   325 TVTEEEIRPSL-----------EKRLEAIISGAALLADSSCTRDLHRERIIA-ECNAIRQALQDL 377

  Fly   338 RQEGKGQSPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQQTAHTIQGRLEQAVKWLQHPEIN 402
            ..|      ...::.:.|..|...|.....|..|   .:|:..:..||.         |.|.||.
Human   378 LSE------YMNNMRKLIPCRATRLTKTAPQVYL---TSGLVDSKSTIS---------LLHHEIK 424

  Fly   403 DGGLGERAINLIVEEGRKVAEGCPGHQKAEIQQLCDEVERLKRQAAGSGPAAKQAAKQLTQKLYE 467
             .|..||:..|.:                .:..:|.:...|:||
Human   425 -AGKKERSNTLNI----------------ALDNMCKKTRDLRRQ--------------------- 451

  Fly   468 LKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGREQNFNQKSNNLQAFSDRASKTSRMV 532
                ::.|:::.:...|:|.:.||....||...     |||:...:.:   ..|.:.   |||:|
Human   452 ----LRKAIIDHVSDSFLDTTVPLLVLIEAAKN-----GREKEIKEYA---AIFHEH---TSRLV 501

  Fly   533 -AAGGACG---NKKIAEILLSSAAQVDSLTPQLISAGRIRMNYPGSKAADEHLQNLKQQYADTVL 593
             .|..||.   |:...:|:..:|..:::|.||:|:|.......|.|:|....::..|:.:.:.:.
Human   502 EVANLACSMSTNEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAVKNTMEMYKRTWENHIH 566

  Fly   594 RMRTLCDQATDPADFIKTSEEHMQVYAKLCEDAIHARQPQKMVDNTSNIARLIN----RVLLVAK 654
            .:....|..|...||:..||.|:......|..|:..:.    .||....|..|.    ||..:..
Human   567 VLTEAVDDITSIDDFLAVSESHILEDVNKCIIALRDQD----ADNLDRAAGAIRGRAARVAHIVT 627

  Fly   655 QEADNSEDPVFTERLNAAANRLERS-LPAMVGDAKLVATNIADPAAAAAWKNSF----QRLLGDV 714
            .|.|:.|...:||.:....|.|..: :|..|....:....::..:......|.|    :::...:
Human   628 GEMDSYEPGAYTEGVMRNVNFLTSTVIPEFVTQVNVALEALSKSSLNVLDDNQFVDISKKIYDTI 692

  Fly   715 REVRDAIAPPQPPPLPTSLPPPIPELSAL--------HLSNQ---NAERA--PPRPPLPREGLAP 766
            .::|.::       :....|..:.::|.|        |.|.|   ..:||  ...|...:|.:|
Human   693 HDIRCSV-------MMIRTPEELEDVSDLEEEHEVRSHTSIQTEGKTDRAKMTQLPEAEKEKIA- 749

  Fly   767 VRPPPPETDDEDEGVFRTMPHANQPILIAARGLHQEVRQWSSKDNEIIAAAKRMAILMARLSELV 831
                      |....|:.:...          |..|:..|....|:||..||.|.::|..:::.
Human   750 ----------EQVADFKKVKSK----------LDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDF- 793

  Fly   832 LSDSRGS-----KRELIATAKKIAEASEDVTRLAKELARQCTDRRIRTNLLQVCERIPTIGTQLK 891
               :||.     ..::|..||.|:|:...:..||:::|.||.|...:.:||...|:|.....|||
Human   794 ---TRGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLK 855

  Fly   892 ILSTVKATM--LGAQGSDEDREATEMLVGNAQNLMQSVKETVRAAEGASIKI 941
            |.|.|||.:  ||.:......::...|:..|:|||.:|.:||:.:..||.||
Human   856 ICSQVKAEIQNLGGELIMSALDSVTSLIQAAKNLMNAVVQTVKMSYIASTKI 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_476820.1	Vinculin	3..960	CDD:460040	213/1027 (21%)
CTNNA3	XP_016871641.1	Vinculin	30..931	CDD:460040	213/1027 (21%)