Protein Alignment Vinc and Vcl

DIOPT Version :10

• Sequence 1: NP_476820.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: XP_006518985.1
• Gene: Vcl / 22330
• MGIID: 98927
• Length: 1134
• Species: Mus musculus
• Alignment Length: 1148
• Identity: 470/1148 - (40%)
• Similarity: 646/1148 - (56%)
• Gaps: 202/1148 - (17%)

  Fly     1 MPVFHTKTIESILDPVAQQVSRLVILHEEAE-DGNAMPDLSRPVQVVSAAVANLVKVGRDTINSS 64
            ||||||:||||||:|||||:|.|||:|||.| ||.|:|||:.||..|.|||:|||:||::|:.::
Mouse     1 MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTT 65

  Fly    65 DDKILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESE 129
            :|:||::|||.|..:||.|...|.:|:.||:|||||.|||..||:||||||.|||.|||.|||:|
Mouse    66 EDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAE 130

  Fly   130 VRKIIQECKRVLDYLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEILVRCL 194
            |||||:.||.:|:||.||||:.|||.||.:.|:|.|.::|:.:.:..|::|||||.|..:||..:
Mouse   131 VRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSM 195

  Fly   195 EQVKTLAPILICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRVLQLTTYDEDTSEL 259
            ..||.|.|:||.:||:::.....:.:|.|||.:|||:...:||.|:.|||||||||::|||....
Mouse   196 NTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260

  Fly   260 DNLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEISERCL----------- 313
            .:...:|:...:|.:|:.||..||.:|.|..|..||:|:||::|.|.::.|.|.
Mouse   261 KDTEAMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTC 325

  Fly   314 ----------------PQDSYPI------------------------------------------ 320
                            .|.:.|:
Mouse   326 KMLGQMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDA 390

  Fly   321 -------------------------RKLAD----------------EVTAMANTLCELRQEGKGQ 344
                                     ||:|:                |:.|:.:.|.:||::|||.
Mouse   391 AQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEIAALTSKLGDLRRQGKGD 455

  Fly   345 SPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQQTAHTIQGRLEQAVKWLQHPEINDGGLGER 409
            ||:|.:|.:.:...:..|::..::||.....|   :.|..::|::|||.:|:.:|.::|.|:|:.
Mouse   456 SPEARALAKQVATALQNLQTKTNRAVANSRPA---KAAVHLEGKIEQAQRWIDNPTVDDRGVGQA 517

  Fly   410 AINLIVEEGRKVAEGCPGHQKAEIQQLCDEVERLKRQAA-------GSGPAAKQAAKQLTQKLYE 467
            ||..:|.||.::|....|..:.::...||.|::|..|.|       |..|.|:..|.||...|.:
Mouse   518 AIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKD 582

  Fly   468 LKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGREQNFNQKSNNLQAFSDRASKTSRMV 532
            |||.:|.|:...:...|.|.:||:|....|...|...|.||:.|::::.|.:..|.|...|:...
Mouse   583 LKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKA 647

  Fly   533 AAGGACGNKKIAEILLSSAAQVDSLTPQLISAGRIRMNYPGSKAADEHLQNLKQQYADTVLRMRT 597
            ||.|. .||...|.:.:|......||||:|||.||.:..||::||.||.:.:|.|:.|.|.:|..
Mouse   648 AAVGT-ANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTG 711

  Fly   598 LCDQATDPADFIKTSEEHMQVYAKLCEDAIHARQPQKMVDNTSNIARLINRVLLVAKQEADNSED 662
            |.|:|.|....:..|||.::.....|:.|:...|||.:|...::|||..||:|||||:|.:||||
Mouse   712 LVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSED 776

  Fly   663 PVFTERLNAAANRLERSLPAMVGDAKLVATNIADPAAAAAWKNSFQRLLGDVREVRDAIAPPQPP 727
            |.|.|.:.||::.|.:::..||.|||.||.||:||....::.:|..|:||.|.:||:|..|.:|
Mouse   777 PKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP- 840

  Fly   728 PLPTSLPPPIPELSALHLSNQNAERAPPRPPLPREGLAPVRPPPPETDDED-------------- 778
                ..|||.|:|..|.|::   |.|||:||||...:.|.||||||..||:
Mouse   841 ----DFPPPPPDLEQLRLTD---ELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPM 898

  Fly   779 ---------------------------------------------------EGVFRTMPH---AN 789
                                                               |.....||.   .|
Mouse   899 MMAARQLHDEARKWSSKPGIPAAQVGIGVVAEANAADAVGFPFPSDMEDDYEPELLLMPSNQPVN 963

  Fly   790 QPILIAARGLHQEVRQWSSKDNEIIAAAKRMAILMARLSELVLSDSRGSKRELIATAKKIAEASE 854
            ||||.||:.||:|..:||||.|:|||||||||:|||.:|.||...| |:||.||..||.||:||:
Mouse   964 QPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGS-GTKRALIQCAKDIAKASD 1027

  Fly   855 DVTRLAKELARQCTDRRIRTNLLQVCERIPTIGTQLKILSTVKATMLGAQG-SDEDRE-ATEMLV 917
            :|||||||:|:||||:||||||||||||||||.|||||||||||||||... |||:.| ||||||
Mouse  1028 EVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLV 1092

  Fly   918 GNAQNLMQSVKETVRAAEGASIKIRSDQTSNRLQWVRRQPWYQ 960
            .||||||||||||||.||.||||||:| ....|:|||:.||||
Mouse  1093 HNAQNLMQSVKETVREAEAASIKIRTD-AGFTLRWVRKTPWYQ 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_476820.1	Vinculin	3..960	CDD:460040	466/1144 (41%)
Vcl	XP_006518985.1	Vinculin	3..1134	CDD:460040	466/1144 (41%)