Protein Alignment Vinc and deb-1

DIOPT Version :10

• Sequence 1: NP_476820.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_001293743.1
• Gene: deb-1 / 177482
• WormBaseID: WBGene00000942
• Length: 1090
• Species: Caenorhabditis elegans
• Alignment Length: 1099
• Identity: 498/1099 - (45%)
• Similarity: 675/1099 - (61%)
• Gaps: 147/1099 - (13%)

  Fly     1 MPVFHTKTIESILDPVAQQ---------------------------------------------- 19
            ||||||||||:||:|||||
 Worm     1 MPVFHTKTIENILEPVAQQLHYVLAMAEKNATSVDEVRHLGTSMPNLDRFASRSALALSRASSRR 65

  Fly    20 ----------------------------------VSRLVILHEEAEDGNAMPDLSRPVQVVSAAV 50
                                              |||||||||||.||||||||:.||.:||.||
 Worm    66 SIPEYITPDTVRHVVNDDDCPVCQLMMPRGKDGCVSRLVILHEEANDGNAMPDLTGPVGMVSRAV 130

  Fly    51 ANLVKVGRDTINSSDDKILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGIL 115
            .||::||.||.:.|||:||:||||.||.||||:|:||||:|..|:.||||.|||||||:|:||||
 Worm   131 GNLIQVGYDTCDHSDDRILQQDMPPALQRVEGSSKLLEESSYSLKHDPYSVPARKKLIDGARGIL 195

  Fly   116 QGTSSLLLCFDESEVRKIIQECKRVLDYLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKE 180
            ||||:||||||||||||||:.|::..||:||:|||.:|..|.||:||:||.|..|..:|..|::|
 Worm   196 QGTSALLLCFDESEVRKIIRVCRKANDYVAVSEVIESMADLQQFVKDISPVLHDVTNDVNLRQQE 260

  Fly   181 LTHQVHSEILVRCLEQVKTLAPILICSMKVYIHIVEQQGR-GAEEAAENRNYLAARMSDELQEII 244
            ||||||.|||:||::.:|.:|||||||||..|.:.....| |..||..|||:::.||::|:.|||
 Worm   261 LTHQVHREILIRCMDSIKVIAPILICSMKTSIELGTPHPRQGHAEAIANRNFMSQRMTEEMNEII 325

  Fly   245 RVLQLTTYDEDTSELDNLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEIS 309
            |||||||||||..:.||:||::|..:|..:.:..|.:||::|:|..|.|||||:|::.:.|..||
 Worm   326 RVLQLTTYDEDEWDADNVTVMRKALSAAKSLLTAALDWLADPHARSGAVGEKAIRRICEYADRIS 390

  Fly   310 ERCLPQDSYPIRKLADEVTAMANTLCELRQEGKGQSPQAESL----VRGIRDRMGELKS--LVHQ 368
            .|.||:|:..|::...|:|:..:.||.||..|:   |..|:|    .|.::|.:|...|  |:..
 Worm   391 ARALPEDAQSIKRSIFEITSFTDELCNLRNNGQ---PDRENLAAQTARRLKDLVGSQNSSGLMGD 452

  Fly   369 AVLGVDKAGVQQTAHTIQGRLEQAVKWLQHPEINDGGLGERAINLIVEEGRKVAEGCPGHQKAEI 433
            |:....:.|....|||..||||||::||.:|.::|||||.:|:.|:..:.||:|:......:..:
 Worm   453 ALQNAQRHGGANPAHTAAGRLEQALRWLDNPGLDDGGLGLQALRLLTADARKLADRLNPQDRNRL 517

  Fly   434 QQLCDEVER-------LKRQAAGSGPAAKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDVSTPL 491
            ..||.:::|       |:|:..|:.|.|.|...||...|.:|...::..|.:|:|.||.|::|||
 Worm   518 LGLCSDIDRLAAQLADLERRGLGNSPEAHQIRNQLKNALRDLGDFMRRVLTDRVVDDFADITTPL 582

  Fly   492 KQFTEAVLQPEGTPGREQNFNQKSNNLQAFSDRASKTSRMVAAGGACGNKKIAEILLSSAAQVDS 556
            |||.|||......|.|||||..||..|...|...:.|:|:||:.|...:||..|.:|.:|.:|:.
 Worm   583 KQFVEAVHADPYDPNREQNFVDKSQRLTDHSQSMTTTARLVASCGPSKSKKTVEAILDTAEKVEQ 647

  Fly   557 LTPQLISAGRIRMNYPGSKAADEHLQNLKQQYADTVLRMRTLCDQATDPADFIKTSEEHMQVYAK 621
            |||||::|||:|::.|||   ::|.:|:.:||||.:.|:|:..|.|.|..:|::.||..|:.|..
 Worm   648 LTPQLVNAGRVRLHNPGS---EQHFENIHKQYADALHRLRSHVDDAIDTGEFVRASETAMRRYTN 709

  Fly   622 LCEDAIHARQPQKMVDNTSNIARLINRVLLVAKQEADNSEDPVFTERLNAAANRLERSLPAMVGD 686
            .||.||:......:|:|:|.||||.||||:.|:.||||||:|.|..|:..||::|..::|.||.:
 Worm   710 HCEGAINGADAHGLVNNSSQIARLGNRVLMTAQNEADNSEEPSFVSRVRNAADQLHNAIPPMVNN 774

  Fly   687 AKLVATNIADPAAAAAWKNSFQRLLGDVREVRDAI-------------------APPQPPPLPTS 732
            ||.:|.|..|..||..|:.:...||..||.|.|||                   |.|..||.|:|
 Worm   775 AKQIAQNPHDQYAAQNWRGTNDHLLNSVRAVGDAITGVPMSNGRHSSYQESISRASPYNPPPPSS 839

  Fly   733 --------LPPPIPELSALHLSNQNAERAPPRPPLPREGLAPVRPPPPETDDEDEGVFR-----T 784
                    .||..|.:....:..::.. ||||||.|.|...|.|||||...||:|....     .
 Worm   840 QVIRSVNASPPTAPIIHNKMIIREDIP-APPRPPPPVELSPPPRPPPPPEYDEEEETRAFWERYP 903

  Fly   785 MPHA-NQPILIAARGLHQEVRQWSSKDNEIIAAAKRMAILMARLSELVLSDSRGSKRELIATAKK 848
            :|.| :||:|.||..||.|::||||::|:|:||||||||||||||:||..:. |:|::||..:|.
 Worm   904 LPQASHQPMLAAAHNLHNELKQWSSQENDIVAAAKRMAILMARLSQLVRGEG-GTKKDLINCSKA 967

  Fly   849 IAEASEDVTRLAKELARQCTDRRIRTNLLQVCERIPTIGTQLKILSTVKATMLGA---------- 903
            ||::||:|||||.:|||.|||.::||.||||.||||||.||||:||||||||||:
 Worm   968 IADSSEEVTRLAVQLARLCTDIKMRTALLQVSERIPTIATQLKVLSTVKATMLGSANVIGPYGQP 1032

  Fly   904 -QGSDEDREATEMLVGNAQNLMQSVKETVRAAEGASIKIRSDQTSNRLQWVRRQPWYQY 961
             :||:||.||.:.||.||||||||||:.|||||.||||||:: :..||:|:|:..|..:
 Worm  1033 VEGSEEDDEAMQQLVHNAQNLMQSVKDVVRAAEAASIKIRTN-SGLRLRWLRKPMWSNF 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_476820.1	Vinculin	3..960	CDD:460040	496/1094 (45%)
deb-1	NP_001293743.1	Vinculin	81..1089	CDD:460040	481/1016 (47%)