Protein Alignment Vinc and ctnnal1

DIOPT Version :10

• Sequence 1: NP_476820.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_001137526.1
• Gene: ctnnal1 / 100034581
• ZFINID: ZDB-GENE-060503-507
• Length: 754
• Species: Danio rerio
• Alignment Length: 970
• Identity: 165/970 - (17%)
• Similarity: 296/970 - (30%)
• Gaps: 345/970 - (35%)

  Fly     6 TKTIESILDPVAQQVSRLVILHEE--AEDGNAMPDLSRPVQVVSAAVANLVKVGRDTINSSDDKI 68
            |:::|..|.|:..|::.| |.|::  .:....:..:.|..|.||.||...|.||......::|
Zfish    19 TRSVEQTLIPLVSQITTL-INHKDKLKKTEKTLRAIQRVGQAVSVAVGRFVAVGEAIAAENED-- 80

  Fly    69 LRQDMPSALHRVE----GASQL-----LEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLC 124
            |:::|..|.....    |.:||     ||......||..:|.  |..:::.:|.:|...:.:|:.
Zfish    81 LKEEMGLACFEARRAGTGIAQLTDVSSLEHCDGDGRSTVFSD--RTGMVKAARMLLSSVTKVLVL 143

  Fly   125 FDESEVRKIIQECKRVLDYLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEI 189
            .|...:::||....:||..|...|.::|.::.||........:.:.....|.|:.:|..:.....
Zfish   144 ADCIVIKQIISSRNKVLVTLEQLERVSTFQEFVQIFSQFGNEMVEFAHLTGDRQNDLKDEKKRAR 208

  Fly   190 LVRCLEQVKTLAPILICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRVLQLTTYDE 254
            :......::....:|:.:.|..:...:     .|.|..|:..:..||...|:::|.:
Zfish   209 MAAARAVLEKCTMMLLTASKTCLRHPD-----CESARINKEAVFQRMRIALEQVIEI-------- 260

  Fly   255 DTSELDNLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEISERCLPQDSYP 319
                                                          |.|..:....:.||...|.
Zfish   261 ----------------------------------------------VTDTRSSGEAKALPVSIYA 279

  Fly   320 -IRKLADEVTAMANTL----CELRQEGKGQSPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQ 379
             |:....:|.|:.::|    ||      ..:.|.|:||....|                    ..
Zfish   280 GIKDFKVKVEALRDSLYGVSCE------AVAAQLEALVEKTED--------------------FT 318

  Fly   380 QTAHTIQGRLEQAVKWLQHPEINDGGLGERAINLIVEEGRKVAEGCPGHQKAEIQQLCDEVER-- 442
            .:|:|...:.|..::..|               :..:|.:::.......|..:.::..||:|.
Zfish   319 DSAYTRHEQRETIIQLCQ---------------ITRQETKQLINTWRHAQSLKAKEATDEMELSI 368

  Fly   443 LKRQAAGSGPAAKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGR 507
            ||         ..|....|.|:|:::.......|: ::..|.:            |||.....|.
Zfish   369 LK---------TCQCVSDLRQELHKVAVGRATELL-KLHSDHL------------VLQALKASGG 411

  Fly   508 EQNFNQKSNNLQAFSDRAS----------KTSRMVAAGGACGNKKIAEILLSSAAQVDSLTPQLI 562
            :       .||:|.:|.||          :|.|::.  ...|.:.:....:.:......:.||:|
Zfish   412 D-------GNLEAVADYASTLTEHNEQLVETCRLLC--HVSGTEPLEITCIHAEETFRVIGPQII 467

  Fly   563 SAGRIRMNYPGSKAADEHLQNLKQQYADTVLRMRTLCDQATDPADFIKTSEEHMQVYAKLCEDAI 627
            ||.:....:|.||.|.|:|....:.:..      .|||               |.:..|...|..
Zfish   468 SAAQTLALHPTSKIAKENLDVFCEAWES------QLCD---------------MAILLKEINDVF 511

  Fly   628 HARQPQKMVDNTSNIARLINRVLLVAKQEADNSEDPVFTERLNAAANRLERSLPAMVGDAKLVAT 692
            ..|:                                                     ||.|..
Zfish   512 EGRR-----------------------------------------------------GDKKTY-- 521

  Fly   693 NIADPAAAAAWKNSFQRLLGDVREVRDAIAPPQPPPLPTSLPPPIPELSALHLSNQNAERAPPRP 757
                                                  .|||.|     ..|.:|....:|
Zfish   522 --------------------------------------LSLPRP-----GKHSANLKTVKA---- 539

  Fly   758 PLPREGLAPVRPPPPETDDEDEGVFRTMPHANQPILIAARGLHQEVRQWSSKDNEIIAAAKRMAI 822
                          .:.|.|::   .|:......:.:....:..||.:|..:|:|
Zfish   540 --------------AKLDAEEQ---TTIAKLGLELCLLTSDVDSEVERWDEQDHE---------- 577

  Fly   823 LMARLSELVLSDSRGSKRELIATAKKIAEASEDVTRLAKELARQCTDRRIRTNLLQVCERIPTIG 887
             |.||.:::  .|......|....:.:.:.:.|:...|:.|:.|.         ||:|..:.::.
Zfish   578 -MVRLCQII--SSMAYSMYLFTRGEGLLKTTSDLFHQAEVLSDQG---------LQLCPVLQSLS 630

  Fly   888 TQLKILSTVKATMLGAQGSDEDR----EATEMLVGNAQNLMQSVKETVRAAEGASIKIRS 943
            |||               .||||    ..||.|....|.|....|..|:.......|:.|
Zfish   631 TQL---------------LDEDRMLIISETEKLSSACQQLQACAKTPVQGKSAIFQKVDS 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_476820.1	Vinculin	3..960	CDD:460040	165/970 (17%)
ctnnal1	NP_001137526.1	Vinculin	16..>510	CDD:460040	117/647 (18%)