Protein Alignment wapl and Wapl

DIOPT Version :10

• Sequence 1: NP_525042.2
• Gene: wapl / 31187
• FlyBaseID: FBgn0004655
• Length: 1741
• Species: Drosophila melanogaster
• Sequence 2: NP_001414208.1
• Gene: Wapl / 290577
• RGDID: 1590924
• Length: 1198
• Species: Rattus norvegicus
• Alignment Length: 1469
• Identity: 359/1469 - (24%)
• Similarity: 556/1469 - (37%)
• Gaps: 461/1469 - (31%)

  Fly   349 GTSRLVSTDSEEPPSSSPAHQNQLNQLSVTEEEPAERSG----DETVPASTPKITVKPLRPPTAA 409
            |.:..::...::.|:..|..|....:..|.||:..:..|    ||::|.|:
  Rat    36 GETTFMAKLGQKRPNFKPDIQEIPKKPKVEEEDTGDPFGFDSDDESLPVSS-------------- 86

  Fly   410 DSVDGSSAAVG-GASAGDSFE----ERKSQSLEPN--------ED----------EEEEEEEEDE 451
                 .|.|.| |:|..:|.|    |..:..||.|        ||          |:....:|..
  Rat    87 -----KSLAQGKGSSYSESSEAVQLEEVTSVLEANSKCSHAVGEDSFASDRCLLVEDSLIGKEKN 146

  Fly   452 EEEPPEIN----YCTVKISPDKPPKERLKLIIKTDVIRNAIAKAAAAAESRSEKKSRSKKHKHKQ 512
            ....||.|    .||..|:.||                         .|:.||:..::..|.||
  Rat   147 TNRIPEDNANKSSCTKLITSDK-------------------------VENFSEEHEKNSHHFHK- 185

  Fly   513 LLAAGSGAAPASGATPAEINSEFKTPSPH---LALSEA-----------NSQQAQHTPSHLHQLH 563
                               |:|..|..|:   :|.||.           |||.|:.|.|.....
  Rat   186 -------------------NAEDSTKKPNAETVAASECKADETKTSDTWNSQSAKRTESPSESC- 230

  Fly   564 QLHPQRGSAVISPTTRSDHDFDSQSSVLGSISSKGNSTPQLLAQAVQEDSCVIRSRGSSVITSDL 628
               |.:|| |.:.....|:||:.                      ::.:.|:            |
  Rat   231 ---PVKGS-VRTGLYEWDNDFED----------------------IRSEDCI------------L 257

  Fly   629 ETSQHSSLVAPPSDIESRLESMMMTIDGAGTGAASAVPETPLQEDIL-AVLRGEVPRLNGNTDPE 692
            .....|.|.....|:::|:            |....:.|. .:|||: :|||
  Rat   258 SLDNDSLLEMKDEDLKNRI------------GGLENLNEA-FEEDIIQSVLR------------- 296

  Fly   693 PTEEEDQQQQPKRATRGRGRKANNNVDVTPPATETRTRGRAKGADATTAAISPPTGKRNTRGTRG 757
                                           .:..||..||..|             ::::||
  Rat   297 -------------------------------PSNCRTYCRANKA-------------KSSQGT-- 315

  Fly   758 SRKAEQEVDMEVDETAMTTVPANEEQLEQATLPPRRG--------RNAAARANN------NNLAS 808
                 ...|..:|.|:.|...||.|..:......::|        |....|..:      :.|:.
  Rat   316 -----SNFDKLMDGTSQTLAKANSESSKDGLNQAKKGSVSCGTSFRGTVGRTRDYTVLHPSCLSV 375

  Fly   809 VNNNINKIAANLSAKAEASRLAEGGVAGGAARSYGRKRKNQQVTQVLQQEPVPEEQETPDAEEEQ 873
            .|..|.........:..||..|:.|.|       ||.||...:                 |..:.
  Rat   376 CNVTIQDTMERSMDEFTASTPADLGEA-------GRLRKKADI-----------------ATSKT 416

  Fly   874 PTPAKIPHTDHREH-------SPDHDPDPDPDELSNNSNNSSLQHDG----SSSSPPPRD----F 923
            .|..:..:|..::.       ..||| :...||..:.|:|..:::.|    |.|.....|    .
  Rat   417 TTRFRPSNTKSKKDVKLEFFGFEDHD-ETGGDEGGSGSSNYKIKYFGFDDLSESEDDDDDDCQVE 480

  Fly   924 KFKDKFKRTLTLDTQGAANAGAGGAAAAAPPESSGEQR-------GAVKLVISKKKGSIFKSRAL 981
            :.||| |||.|          |...:...|||||...:       .|..|..::....:.:|...
  Rat   481 RKKDK-KRTKT----------APSPSQQPPPESSDNSQDSQSSTNNAENLDFTEDLPGVPESVKK 534

  Fly   982 VPSDQAEQATVAKRHLYKHSWDAALEANGGGTNSDASNASASGVGVAGAKDHLHHLAAGKSDGD- 1045
            ..|.|.:::....|.::            .|.....:.|      |..|: |.:|..:.:..|.
  Rat   535 PISKQGDKSKENTRKIF------------SGPKRSPTKA------VYNAR-HWNHPDSEELPGPP 580

  Fly  1046 -----------FGDSPSSNNNGSSSACSSASTLRGDSPALGKISRLAGKQGVPATSTSSDAFDLD 1099
                       ....|:..::|         ..:..:|.|..|..:.    :|..         .
  Rat   581 IVKPQSVTVRLSSKEPNQKDDG---------VFKAPAPPLKVIKTVT----IPTQ---------P 623

  Fly  1100 LEPIAGELDLERSAAGASAGGTGATTGGGGATGGGGPVRVDRKTKDYYPVVRNVKTAHQIQEIGE 1164
            .:.|...|                              :..::.|:.|.||::||..:.:.|.||
  Rat   624 YQEIVTAL------------------------------KCRKEDKELYTVVQHVKHFNDVVEFGE 658

  Fly  1165 YQEMDDDVEYILDALQPHNPPATRCLSALQLAAKCMMPAFRMHVRAHGVVTKFFKALSDANKDLS 1229
            .||..||:||:|..|:...|..|||||.:.||.||.||:||||:||||:|...||.|.|:....:
  Rat   659 NQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQN 723

  Fly  1230 LGLCTSAIMYILSQEGLNMDLDRDSLELMINLLEADGVGGSTETGHPDRAGYDRNKQKVRELCEE 1294
            |.|||:|:|||||::.|||||||.||:|||.|||.:....|.:.  .:....::.|:|:|.|||.
  Rat   724 LSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKL--LNEKDMNKIKEKIRRLCET 786

  Fly  1295 IKAQGKGTHLNVDSLTVGTLAMETLLSLTSKRAGEWFKEDLRKLGGLEHIIKTISDFCRPVIACD 1359
            :    ...||:::::|.|.|||||||||||||||:||||:||.||||:||:..:.: |...::.|
  Rat   787 V----HNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKE-CVDHLSRD 846

  Fly  1360 TEIDWQPTLLDNMQTVARCLRVLENVTQHNETNQRYM-------LTSGQGKAV---ETLCQLYRL 1414
            .:   :..|:.::....|||||||:||.||..||.|:       |.....||:   |.|.|.|..
  Rat   847 ED---EEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIISSAKALQHCEDLIQQYNR 908

  Fly  1415 CSRQIMLHPSDGGGSNK--------EHPGVAMRELLVPVLKVLINLTHTFNEAQPSLGAELLGQR 1471
            ....|.:      ..:|        .|.|.|:.:.:..::.||:|||:. ||    .|:...|::
  Rat   909 AENSICI------ADSKPLPYQNVTNHVGKAVEDCMRAIIGVLLNLTND-NE----WGSTKTGEQ 962

  Fly  1472 GDVVETSFRLLLLSANYIPDQCVFELSILVLTLLINLCMHTVPNRAALMQAAAPAEYVAD----- 1531
            ..::.|:...:|....|:|.:..|::.:|.|.|||||..::..||..|:.......:.:.
  Rat   963 EGLIGTAMNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSFSSGE 1027

  Fly  1532 ---NPPAQGSVSALQALLEYFYKCEELARLVEKNTDAFLE------------------------- 1568
               |....|.|.|:|||::.|.:.|..|:|.|..||..::
  Rat  1028 GDHNLRLAGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVST 1092

  Fly  1569 -----SNEKGKKKQEEVEETVNNLVQRAGHHMEHTLKGSYAAILVGNLIADNELYESVVRRQLRG 1628
                 :.||.||:.|:.|..:|..:|.||.|||..:..||.|:|:|.|..::.:..:.||..|..
  Rat  1093 EKTDGAEEKQKKEDEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPE 1157

  Fly  1629 NSFKEIIGVLEKYHTFMNLTSSLEAAFVAHMKSTKRIID 1667
            ..|..:..:|:|:.:|||||.   |......||..|:|:
  Rat  1158 GDFSIMTEMLKKFLSFMNLTC---AVGTTGQKSISRVIE 1193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wapl	NP_525042.2	PHA03307	69..>436	CDD:223039	20/95 (21%)
		WAPL	1152..1515	CDD:462278	151/380 (40%)
Wapl	NP_001414208.1	None