DRSC/TRiP Functional Genomics Resources

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Protein Alignment wapl and WAPL

DIOPT Version :10

Sequence 1:NP_525042.2 Gene:wapl / 31187 FlyBaseID:FBgn0004655 Length:1741 Species:Drosophila melanogaster
Sequence 2:NP_055860.1 Gene:WAPL / 23063 HGNCID:23293 Length:1190 Species:Homo sapiens


Alignment Length:1442 Identity:357/1442 - (24%)
Similarity:563/1442 - (39%) Gaps:415/1442 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 GTSRLVSTDSEEPPSSSPAHQNQLNQLSVTEEEPAERSG----DETVPASTPKITVKPLRPPTAA 409
            |.:..::...::.|:..|..|....:..|.||...:..|    ||::|.|:..:           
Human    36 GETTFMAKLGQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNL----------- 89

  Fly   410 DSVDGSSAAVGGASAGDSFE----ERKSQSLEPN--------------------EDEEEEEEEED 450
                   |.|..:|..:|.|    |..:..||.|                    ||....:|:..
Human    90 -------AQVKCSSYSESSEAAQLEEVTSVLEANSKISHVVVEDTVVSDKCFPLEDTLLGKEKST 147

  Fly   451 EE--EEPPEINYCTVKISPDKPPKERLKLIIKTDVIRNAIAKAAAAAESRSEKKSRSKKHKHKQL 513
            ..  |:...|:.|...|:.||                         .|:..|:..::..|.||. 
Human   148 NRIVEDDASISSCNKLITSDK-------------------------VENFHEEHEKNSHHIHKN- 186

  Fly   514 LAAGSGAAPASGATPAEINSEFKTPSPHLALSEANSQ--QAQHTPSHLHQLHQLHPQRGSAVISP 576
             |..|...|.:..|.|   ||.|..:     ...|||  :...:||      ::.|.:|| |.:.
Human   187 -ADDSTKKPNAETTVA---SEIKETN-----DTWNSQFGKRPESPS------EISPIKGS-VRTG 235

  Fly   577 TTRSDHDFDSQSSVLGSISSKGNSTPQLLAQAVQEDSCVIRSRGSSVITSD--LETSQHSSLVAP 639
            ....|:||:.                      ::.:.|::.      :.||  ||...       
Human   236 LFEWDNDFED----------------------IRSEDCILS------LDSDPLLEMKD------- 265

  Fly   640 PSDIESRLESMMMTIDGAGTGAASAVPETPLQEDIL-AVLRGEVPRLNGNTDPEPTEEEDQQQQP 703
             .|.::|||::                ...::|||: :|||             ||    ..:..
Human   266 -DDFKNRLENL----------------NEAIEEDIVQSVLR-------------PT----NCRTY 296

  Fly   704 KRATRGRGRKANNNVDVTPPATETRTRGRAKGADATTAAISPPTGKRNTRGTRGSRKA------- 761
            .||.:.:..:..:|.|              |..|.|:.|::....:.:..|...::|.       
Human   297 CRANKTKSSQGASNFD--------------KLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTS 347

  Fly   762 -EQEVDMEVDETAM----------TTVPANEEQLEQATLPPRRGRNAAARANNN-NLASVNNNIN 814
             ...|....|.|.:          |.....|..:::.|.........|.|.... ::|:......
Human   348 FRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTR 412

  Fly   815 KIAANLSAKAEASRL--------AEGGVAGGAARSYGRKRKNQQVTQV----LQQEPVPEEQETP 867
            ...:|..:|.:. :|        ..||..||:..|      |.::...    |.:.   |:.|..
Human   413 FRPSNTKSKKDV-KLEFFGFEDHETGGDEGGSGSS------NYKIKYFGFDDLSES---EDDEDD 467

  Fly   868 DAEEEQPTPAKIPHTDHREHSPDHDPDPDPDELSNNSNNSSLQHDGSSSSPPPRDFKFKDKFKRT 932
            |.:.|:.|..|...|   ..||...|.|:       ||::|......:::....||         
Human   468 DCQVERKTSKKRTKT---APSPSLQPPPE-------SNDNSQDSQSGTNNAENLDF--------- 513

  Fly   933 LTLDTQGAANAGAGGAAAAAPPESSGEQRGAVKLVISKKKGSIFKSRALVPSDQAEQATVAKRHL 997
             |.|..|.             |||       ||..|:|:            .|::::.|   |.:
Human   514 -TEDLPGV-------------PES-------VKKPINKQ------------GDKSKENT---RKI 542

  Fly   998 YKHSWDAALEANGGGTNSDASNASASGVGVAGAKDHLHHLAAGKSDGDFGDSPSSNNNGSSSACS 1062
            :            .|.....:.|      |..|: |.:|..:.:..|.....|.|          
Human   543 F------------SGPKRSPTKA------VYNAR-HWNHPDSEELPGPPVVKPQS---------- 578

  Fly  1063 SASTLRGDSPALGKISRLAGKQ------GV-PATSTSSDAFDLDLEPIAGELDLERSAAGASAGG 1120
                         ...||:.|:      || .|.:..|........|.....|:..:        
Human   579 -------------VTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTA-------- 622

  Fly  1121 TGATTGGGGATGGGGPVRVDRKTKDYYPVVRNVKTAHQIQEIGEYQEMDDDVEYILDALQPHNPP 1185
                            ::..|:.|:.|.||::||..:.:.|.||.||..||:||:|..|:...|.
Human   623 ----------------LKCRREDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPL 671

  Fly  1186 ATRCLSALQLAAKCMMPAFRMHVRAHGVVTKFFKALSDANKDLSLGLCTSAIMYILSQEGLNMDL 1250
            .|||||.:.||.||.||:||||:||||:|...||.|.|:....:|.|||:|:|||||::.|||||
Human   672 NTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDL 736

  Fly  1251 DRDSLELMINLLEADGVGGSTETGHPDRAGYDRNKQKVRELCEEIKAQGKGTHLNVDSLTVGTLA 1315
            ||.||:|||.|||.:....|.:.  .:....::.|:|:|.|||.:    ...||:::::|.|.||
Human   737 DRASLDLMIRLLELEQDASSAKL--LNEKDMNKIKEKIRRLCETV----HNKHLDLENITTGHLA 795

  Fly  1316 METLLSLTSKRAGEWFKEDLRKLGGLEHIIKTISDFCRPVIACDTEIDWQPTLLDNMQTVARCLR 1380
            |||||||||||||:||||:||.||||:||:..:.: |...::.|.:   :..|:.::....||||
Human   796 METLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKE-CVDHLSRDED---EEKLVASLWGAERCLR 856

  Fly  1381 VLENVTQHNETNQRYM-------LTSGQGKAV---ETLCQLYRLCSRQIMLHPSD--GGGSNKEH 1433
            |||:||.||..||.|:       |.....||:   |.|.|.|......|.|..|.  ...:...|
Human   857 VLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNH 921

  Fly  1434 PGVAMRELLVPVLKVLINLTHTFNEAQPSLGAELLGQRGDVVETSFRLLLLSANYIPDQCVFELS 1498
            .|.|:.:.:..::.||:|||:. ||    .|:...|::..::.|:...:|....|:|.:..|::.
Human   922 VGKAVEDCMRAIIGVLLNLTND-NE----WGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIR 981

  Fly  1499 ILVLTLLINLCMHTVPNRAALMQAAAPAEYVA--------DNPPAQGSVSALQALLEYFYKCEEL 1555
            :|.|.|||||..::..||..|:.......:.:        |:....|.|.|:|||::.|.:.|..
Human   982 VLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQVHAVQALVQLFLERERA 1046

  Fly  1556 ARLVEKNTDAFLE------------------------------SNEKGKKKQEEVEETVNNLVQR 1590
            |:|.|..||..::                              :.||.||::|:.|..:|..:|.
Human  1047 AQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGTEEKHKKEEEDEELDLNKALQH 1111

  Fly  1591 AGHHMEHTLKGSYAAILVGNLIADNELYESVVRRQLRGNSFKEIIGVLEKYHTFMNLTSSLEAAF 1655
            ||.|||..:..||.|:|:|.|..::.:..:.||..|....|..:..:|:|:.:|||||.   |..
Human  1112 AGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTC---AVG 1173

  Fly  1656 VAHMKSTKRIID 1667
            ....||..|:|:
Human  1174 TTGQKSISRVIE 1185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
waplNP_525042.2 PHA03307 69..>436 CDD:223039 18/94 (19%)
WAPL 1152..1515 CDD:462278 152/374 (41%)
WAPLNP_055860.1 Mediates interaction with the cohesin complex 1..659 162/896 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..82 9/35 (26%)
FGF motif 1 73..75 0/1 (0%)
FGF motif 2 429..431 0/1 (0%)
FGF motif 3 453..455 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 459..553 30/163 (18%)
WAPL 638..998 CDD:462278 152/374 (41%)
Blue background indicates that the domain is not in the aligned region.

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