DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-p and phc3

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	XP_009296927.1	Gene:	phc3 / 558094	ZFINID:	ZDB-GENE-070912-369	Length:	890	Species:	Danio rerio

Alignment Length:	1004	Identity:	236/1004 - (23%)
Similarity:	362/1004 - (36%)	Gaps:	298/1004 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   739 VNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQM----LQQQIA 799
            |..|...:...:.|||.|.|.|           :...:|.:|:.| |.:.:.|.|    |||..|
Zfish    18 VTTASTTVTSTTPTGTSIPLGN-----------ISSDRQAVQVIQ-QTLHRPQSMTAQYLQQMYA 70

  Fly   800 AIQMQ--QQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQH 862
            |.|..  .|.||:|.|||.||.::..|.:......|              |....|.::...:.|
Zfish    71 AQQQHILLQTAALQQQQQHQQNLTAAQILTTTDTAA--------------QTNGSQFISSPSSSH 121

  Fly   863 QQA--LANATQQILQVAPNQFITSHQQQQQQQLHNQ---LIQQQ---LQQQAQAQVQAQVQAQAQ 919
            ...  |||.||..:.: |...:|....:.|....:.   .|.||   |...:....|||:..:.|
Zfish   122 GNGPQLANVTQTSIPI-PTSPVTQPMARIQVTSSSSTGGAISQQAMLLGNSSPTGSQAQMYLRTQ 185

  Fly   920 QQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSST-TPAGIATSSAL 983
            ............:|..:...|..:||..|.|.|              |::..| .|..:.||..:
Zfish   186 MLILTPAATVAAVQPDLTVVSSISSQSASSQVQ--------------SLALRTHLPGALTTSQNI 236

  Fly   984 QAALSASGAIFQTAKP--GTC---SSSSP-----TSSVVTITNQ-----SSTPLVTSSTVASIQQ 1033
            |......|....:..|  ..|   |:..|     ||..|::.|.     |:.|.:..||...:|.
Zfish   237 QIKPPLQGQTLVSPPPKMSICPLKSTQLPQNLVETSRSVSVLNNVTQTPSAQPAIPPSTFTPVQS 301

  Fly  1034 AQTQSAQVH-------------------QHQQLISATIAGGTQQQPQGPPSL----TPTT----- 1070
            .|....|:|                   .|:||...|:....|.....|.:|    ||||
Zfish   302 HQLIRHQLHCPSGPRVAPQHLIIQQSSSTHRQLHPITLRVTAQDGSPTPFTLHTRTTPTTATVQS 366

  Fly  1071 --NPILAMTSMMNATVGHLS-TAPPVTVSVTSTAVTSSPGQLVLLSTASSGGGGSIPATPTKETP 1132
              ..:|::.|..|.|..... |:||        ||...|..|.|         |......::.||
Zfish   367 QQTELLSVPSSTNQTANQTKYTSPP--------AVLPDPPPLHL---------GPALEPVSQYTP 414

  Fly  1133 SKGP--------------TATLVPIGSPKTPVSGKDTCTT------PKSSTPATVSASV------ 1171
            ...|              :...|.:.|..|.:|.::...|      |..|.|...:.:|
Zfish   415 LSCPPPLKLVQPQRLALRSVQAVEVQSDHTLLSEEELPLTEAVLQLPFQSLPPPQTVAVDLKVQP 479

  Fly  1172 ----EASSST----GEALSNGDASDRSSTP--SKGATTPTSKQSNAAVQPPSST------TPNSV 1220
                |||..|    .|.|:....::.:|.|  |:.:::||..||:   :|..|:      ..|..
Zfish   480 ATQTEASQVTPLLESENLTLVTDAEHASPPQNSRTSSSPTLSQSD---EPQRSSDVVTDQPENLT 541

  Fly  1221 SGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFITSCTSTTTTT 1285
            :.:|:|.:.:..|:..:....|..|         ::.|..:|:|             ..|::..:
Zfish   542 ADQEQPCVPSSRSVIRSPEEPTHAT---------SSPSPLLSSA-------------VRSSSRLS 584

  Fly  1286 TSSISNGSKDLP-KAMIKPNVLTHVIDGFIIQEANEPFPVTR----------------------- 1326
            ::|:....:..| :|:.:|::|||:|:||:|:|..|||||..
Zfish   585 SASLPESPEGRPSQAISRPHILTHLIEGFVIREGLEPFPVRHVSLEMNLQATLPENREDGESALI 649

  Fly  1327 -----QRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKME-HKAKLKRKRYCSP 1385
                 ...:|.|:.|.|.:.:.|::   ||        .:::.||.|||.. .:|.|:.||:||.
Zfish   650 DADHPDSSSDSDIDDPPAEDEQTVE---KL--------PEVLECEFCGKRGLAQAFLRSKRFCSM 703

  Fly  1386 GCSRQ----------------------AKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMA 1428
            .|:|:                      ...|..|..|...||            :..:.|.....
Zfish   704 TCARRFNLRCKKRLNRLREEKVTYWPHRSMGKRGRPSRCLNG------------SAREHLPRPQL 756

  Fly  1429 EEKMQTEATPKLSESFPILGASTEVPPMSLPVQAAISA-----------PSPLAMPLGSPLSVAL 1482
            :...|......:|.|..:.....|.||..:..:..:.|           .|.:....||.|.:
Zfish   757 QGSHQASDNQMVSNSVWMEREEEEDPPGPMTTRLRLQAEREKEQNREQEQSRVESSSGSELLL-- 819

  Fly  1483 PTLAPLSVVTSGAAPKSSEVNGTDRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLL 1547
                                   |..| |.|||:.|.:||..||||.|...:|..||||||||||
Zfish   820 -----------------------DSSP-SQWSVEQVCSFISTLPGCHDVAAEFGCQEIDGQALLL 860

  Fly  1548 LKEKHLVNAMGMKLGPALKIVAKVESIKE 1576
            |.|.||::||.:||||||||.|.:.::|:
Zfish   861 LTEDHLMSAMNLKLGPALKICAHINTLKQ 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	39/67 (58%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	38/64 (59%)
phc3	XP_009296927.1	SAM_Ph1,2,3	821..889	CDD:188976	39/68 (57%)
phc3	XP_009296927.1	SAM	823..890	CDD:197735	40/68 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4720
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030