DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ph-p and sfmbt2

DIOPT Version :9

Sequence 1:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster
Sequence 2:	XP_005164891.1	Gene:	sfmbt2 / 555450	ZFINID:	ZDB-GENE-041210-196	Length:	861	Species:	Danio rerio

Alignment Length:	766	Identity:	157/766 - (20%)
Similarity:	240/766 - (31%)	Gaps:	233/766 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   950 QQQHHQSGQLQLSSV----------PFSVSSSTTPAGIATSSALQAALSASGAIFQTAKPGT--C 1002
            |.|.:..|:|.||.|          .|.:.:...|.|.|..:.|            ..||.|  |
Zfish   180 QVQRNVGGRLCLSYVGLNDPSYYMWMFYLDTRLRPLGWAKENNL------------PMKPPTDLC 232

  Fly  1003 ---SSSSPTSSVVTITNQS-STPLVTSSTVASIQQAQTQSAQVHQHQ-------QLISATIAGGT 1056
               |||..|:::...|.:: :.||..        :.....|.:|.|.       :::|
Zfish   233 DLRSSSEWTTALDEATAEALNNPLPL--------EVFKDHADLHTHSFRAGMKLEMVS------- 282

  Fly  1057 QQQPQGPPSLTPTTNPILAMTSMMNATVGHLS-TAPPVTVSVTSTAV---TSSPGQLVLLSTASS 1117
               |..|..:.|     :::|.:.|..  |.. |...:|...|.|:.   ..|||.|.:.....:
Zfish   283 ---PVEPFHICP-----VSVTKVYNEY--HFQITVDDLTADATPTSAVCHAESPGILPVQWCLKN 337

  Fly  1118 GGGGSIP----------ATPTKETPSKGPTATLVPIGSPK------------TPVSGKDTCTTP- 1159
            |.....|          |...|.|.::.......|..|..            .|:...:.|...
Zfish   338 GVELERPRGFETQDFDWADYLKHTSTEAAPDACFPNASQSRGFCKDMWLEAVNPLHPAELCVARI 402

  Fly  1160 ------------KSSTPATVSASVEASS----STGEALSNGDASDRSSTPSKGATTPTSKQSNAA 1208
                        :..|.......|:..|    ..|...:||.....|   .|....|..|  .|.
Zfish   403 TQVKGCLLWLRLEGLTKPLPDCIVDVESMNIFPVGWCEANGYPLTHS---LKTVCLPQKK--IAV 462

  Fly  1209 VQPPSSTTPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGT 1273
            |||.....|:     :.|.:    .::..:|....:.:.||                 ....|..
Zfish   463 VQPEKQLAPS-----QSPDI----PISLCSSAPMDSGLVNG-----------------KYCCSQL 501

  Fly  1274 FIT-SCTSTTTTTTSSISNGSKDLPK-------AMIKPNVLTHVIDGFIIQEANEPFPVTR--QR 1328
            ||. .|.|........|:    :|||       |::...:||     .:|..|.:|..|.|  |.
Zfish   502 FINHRCFSGPYLNKGRIA----ELPKAVGPGKCAVVLKEILT-----MLINSAYKPGRVLRELQM 557

  Fly  1329 YADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVA--CEQ-CGKMEHKAKLKRKRY----CSPG 1386
            ..|...:.:....||..:.....|.:.....:|.|:  |.: |.:::....|....:    |...
Zfish   558 VEDPQWNCQEETLKAKYKGKSYRSTMRIVRTADQVSEFCRRVCERLQCCLNLFGPTFVSDKCPEN 622

  Fly  1387 CSRQA--------KNGIGGVGSGETNGLG---------------------TGGIVGV-------D 1415
            ||.|.        |..:|....||....|                     ...|||.       |
Zfish   623 CSSQTKTKYTYYKKRKVGRPSLGENAQDGDLSKPARRRKKRKAIFVQKKRRSSIVGYHTTESPQD 687

  Fly  1416 AMALVDRLDEAMAEEKMQTEATPKLSE------SFPILGASTEVPPMSLPVQAAISAPSPLAMPL 1474
            :....|..::...||.....::..|.|      |.|..|.    ||....:|..::.|
Zfish   688 SDYNYDEDEDEDFEEWGSEASSSSLREEASAHNSLPRRGR----PPRRAALQRRMTHP------- 741

  Fly  1475 GSPLSVALPTLAPLSVVTSGAAPKSSEVNGT---------------DRPPISSWSVDDVSNFIRE 1524
            ||..|   ..::|.....|.:..::.....|               |..|: .|||.||.:||..
Zfish   742 GSETS---DRISPRRTTRSVSYSQNQMARDTNVKMESTEEEDRLVLDTNPL-QWSVSDVVDFITS 802

  Fly  1525 LPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKIVAKVESIK 1575
             ..|......|.:|:|||||||||....:...|.:|||||:|:..::|.:|
Zfish   803 -TDCASLAKIFQEQDIDGQALLLLTLPTVQECMDLKLGPAIKLCHQIERVK 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	29/68 (43%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	28/65 (43%)
sfmbt2	XP_005164891.1	MBT	13..110	CDD:214723
		MBT	134..228	CDD:302657	13/59 (22%)
		MBT	277..348	CDD:280910	17/87 (20%)
		MBT	356..447	CDD:214723	12/90 (13%)
		DUF3588	498..612	CDD:288954	27/122 (22%)
		SAM_Scm-like-4MBT1,2	777..861	CDD:188980	30/78 (38%)
		SAM	788..852	CDD:197735	28/65 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910