Protein Alignment CG4281 and SQS1

DIOPT Version :10

• Sequence 1: NP_569973.1
• Gene: CG4281 / 31171
• FlyBaseID: FBgn0025626
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_014175.1
• Gene: SQS1 / 855497
• SGDID: S000005168
• Length: 767
• Species: Saccharomyces cerevisiae
• Alignment Length: 811
• Identity: 139/811 - (17%)
• Similarity: 261/811 - (32%)
• Gaps: 281/811 - (34%)

  Fly    56 ALNQGHHHGHHGHHHHHHHTS----ANVDGLDTHNLKLPASDSDEKAEAMLPLRLPLTLPIRMGA 116
            |....|:.|....|....::.    .|..|:....:|...:.::....:.:||          |.
Yeast     2 AKRHSHYQGSRRRHARGSNSKKAGRGNAKGIQGRKIKKKPTPTNSWHNSSIPL----------GE 56

  Fly   117 LESDSLNETTFSPAR-FYKPNSRRKRKIKRMSMEFEFSKDT-SHTFTESPLQPSLLSSSGSATGT 179
            .:.|.:. ..|:|.| |..|.:..         ::.|.:|. |.:.....|:|.....|.:
Yeast    57 GDLDDVG-ADFNPGRAFISPKTIE---------DYYFGRDAKSRSMKMGGLRPGNRYDSST---- 107

  Fly   180 IRKRLLKIDATGHRSHLFFCGKRKRSNRDRYHEQDSVKLYALPHSQVDDQHVEQPQHQQ-QRMRP 243
                    |....|:..     |||                 |...|..:.|..|.|.. |::|.
Yeast   108 --------DLQAGRAAF-----RKR-----------------PMQFVKAKEVYDPSHNMIQKLRA 142

  Fly   244 RSYSSTSKPLSDRLLPL--NKGLLSK----INRMAAQGQQTKHTQKTETKDKDLKCHRSEGPEG- 301
            ::.:..|:.:.:|...:  ..|.::.    ||...::.:. ..:|.:.:.|..|..:.|:..:|
Yeast   143 KNETKNSEEIVEREADVFEEPGKMTSDVEYINNEDSENED-DDSQNSPSTDHSLSSNESKVEDGD 206

  Fly   302 ---VSLEMEELPD----QKDAVQKLPLPSADFTTANFNSISMDTIVPVTDID----------ALL 349
               |..|.::.||    ::..::::..|..       .:|..|.|:.:..::          .:.
Yeast   207 LFFVDEEAQQSPDLTKIKRVCIEEIARPRE-------VAIEFDPILTIGKVELSVSEGNESKEIS 264

  Fly   350 LSTP--------PAAPLLRKKAQG--------------------QAPGHSSSSSSKTERRRRFQT 386
            :..|        |.|..:.....|                    ..|.:.||:||:.:     |.
Yeast   265 VDVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDELDYEIETENNSEPLYESSASSEVD-----QG 324

  Fly   387 F------------------PQPQL--QLQAQSMDCSELYDFLSSSSLSSSTDSEAEVG------- 424
            |                  |.|||  .::..|::.::.::. ::.:|.|....|.|.|
Yeast   325 FNYVGQRHNSRADNNLLPSPSPQLTEDIKCLSINGTKTFEG-NNDNLPSPASEELEFGFKEEDFV 388

  Fly   425 ---------GHRRHDTDRE---------GD--------DELTDWPGNEFG-PGARYDPKRKLTKK 462
                     ..|....|..         ||        |.|||:..:|.| |..|........|.
Yeast   389 INTNDIVVSNIRMGGVDNSYYLRCYRLLGDYDFHWIDQDLLTDFVVDELGLPEDRLPAYLNFIKN 453

  Fly   463 SLLPQIR------SDDTIGEDDTLMSGTEAGAVGMEPPSKSPV---QLPESLQDL---------S 509
            ||:|:|.      ||..|.:........|..:...:....|.|   .:.|.|.||         .
Yeast   454 SLIPKIEPAEPTYSDIPISDSSDEGDSYEGDSYEDDEDMASSVVHSDIEEGLDDLIAYTLKHDTE 518

  Fly   510 RFQP----------AGVSEPIEIQNACSEMETNADGTMPA--SRQIES------------EMSGE 550
            ||:.          .|..:.:.|.:|.: ::|....|:.:  |::||:            :....
Yeast   519 RFKTFETKSLETKGKGKKKKLLIDDALA-LDTETLETLQSKFSKRIETKAKKRKAKEDFIDQENR 582

  Fly   551 TSNPFLSSSPPG-HAQGQEVREIRAGCRRINGERPGFSIKMSVNERIARFLQDSQQTQIRLPDIE 614
            .||..|...|.| |.|                         ::.:....||..:.. ::..|.::
Yeast   583 NSNDMLKKYPYGLHIQ-------------------------NIKDEFESFLSRNND-RLTFPPLD 621

  Fly   615 LYETDSMSNLATLYSL-----------TMVVEHGCTVLTKTGNTTQTVSM-DHL--QQGLQPRAD 665
            .:...::..:|..|::           ::|||.    :.||..::...|: |.|  |:.:..|.|
Yeast   622 PHGNKTVMKIAKHYNMKSSKIGKANHTSVVVEK----IKKTKWSSPNYSLIDQLMRQRPVFMRID 682

  Fly   666 L------FGDFKR------RCYGEEGEEEGE 684
            :      ...|:|      :.:.:|||..|:
Yeast   683 IRRPREEQAAFERTKTIRGKFHVKEGEIVGQ 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4281	NP_569973.1	None
SQS1	NP_014175.1	R3H_G-patch	597..654	CDD:100075	8/82 (10%)
		G-patch	721..764	CDD:396249