Protein Alignment CG4313 and BDKRB2

DIOPT Version :10

• Sequence 1: NP_569971.3
• Gene: CG4313 / 31169
• FlyBaseID: FBgn0025632
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_000614.1
• Gene: BDKRB2 / 624
• HGNCID: 1030
• Length: 391
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 90/561 - (16%)
• Similarity: 171/561 - (30%)
• Gaps: 215/561 - (38%)

  Fly     9 TPHPISIALPLSDPYATDHMADQDAVLPVPLSDSLDLDVDVDLNLNMNLNLNVDDRRQVLFEGYS 73
            :|..||:.|.:.          :|:| |...|.|.|:         :|:.|..........:...
Human     3 SPWKISMFLSVR----------EDSV-PTTASFSADM---------LNVTLQGPTLNGTFAQSKC 47

  Fly    74 DELLTIAWVACI------VFIIVGVPGNLLTIVALSRGRQTRNSTAIFIINLSCSDLLFGCFNLP 132
            .::..:.|:..|      |..::....|:..:......:.:.....|::.||:.:||:..| .||
Human    48 PQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILAC-GLP 111

  Fly   133 LAASTFKER-AWTHSDLLCRLFPMLRYGLLAVSLLSVSLITINRYIIIAHPRQYPRIYQRRYLAL 196
            ..|.|.... .|...:.|||:...:....|..|:..:.|::|:||:.:.......|:...|
Human   112 FWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVR---- 172

  Fly   197 MVAGTWITTFSIMIPTWRGVWGIFGLDVSIGSCSIMHDRYGRSPKEFLFIAAFMVPCICIVICYA 261
                 |...:|::|      ||          |:::..    ||
Human   173 -----WAKLYSLVI------WG----------CTLLLS----SP--------------------- 191

  Fly   262 RIFLLVRKAAIRAGTAGKTNVSDVTPSSAPQHQIQAMATPKKPEKVTTSSGEANEPIAGRPFVVE 326
               :||.:........|              |.:.|.                   :...|.::.
Human   192 ---MLVFRTMKEYSDEG--------------HNVTAC-------------------VISYPSLIW 220

  Fly   327 ENLAYIDDNASTDSLPISYSIRRRDQDQQPPPVDANVVLKEREKERDRDQEKVSLGRSQTQLEMG 391
            |....:..|.....||:|.......|..|        ||:..|.::.::
Human   221 EVFTNMLLNVVGFLLPLSVITFCTMQIMQ--------VLRNNEMQKFKE---------------- 261

  Fly   392 KTHGKNPITTSLRTTSFTRFSPRKSHYASMGNTSNASSIYPGRMSAKDRRLLKMILVIFVWFVIC 456
                       ::|                                 :||...::||:.:.|:||
Human   262 -----------IQT---------------------------------ERRATVLVLVVLLLFIIC 282

  Fly   457 YLPITVA------------------KIWKSATEVHWFNIAGYLLIYLTTCINPLIYVLMSSEYRR 503
            :||..::                  :|....|::..|      :.|..:|:|||:||::...:|:
Human   283 WLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASF------MAYSNSCLNPLVYVIVGKRFRK 341

  Fly   504 AYWNLLR-------CHGSPDTQKQRNQANAKRKHLESNRQV 537
            ..|.:.:       |...|  .:..|.....|..:...||:
Human   342 KSWEVYQGVCQKGGCRSEP--IQMENSMGTLRTSISVERQI 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4313	NP_569971.3	7tmA_GPR84-like	78..505	CDD:320338	71/451 (16%)
		TM helix 1	79..105	CDD:320338	4/31 (13%)
		TM helix 2	112..135	CDD:320338	8/22 (36%)
		TM helix 3	150..180	CDD:320338	8/29 (28%)
		TM helix 4	194..212	CDD:320338	3/17 (18%)
		TM helix 5	237..262	CDD:320338	2/24 (8%)
		TM helix 6	437..467	CDD:320338	10/47 (21%)
		TM helix 7	473..498	CDD:320338	8/24 (33%)
BDKRB2	NP_000614.1	7tmA_BK-2	58..343	CDD:320503	70/445 (16%)
		TM helix 1	59..85	CDD:320503	3/25 (12%)
		TM helix 2	92..117	CDD:320503	9/25 (36%)
		TM helix 3	130..160	CDD:320503	8/29 (28%)
		TM helix 4	173..194	CDD:320503	8/64 (13%)
		TM helix 5	221..250	CDD:320503	7/36 (19%)
		TM helix 6	263..293	CDD:320503	10/62 (16%)
		TM helix 7	311..336	CDD:320503	9/30 (30%)