Protein Alignment CG4313 and tkr-1

DIOPT Version :10

• Sequence 1: NP_569971.3
• Gene: CG4313 / 31169
• FlyBaseID: FBgn0025632
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_499064.2
• Gene: tkr-1 / 192055
• WormBaseID: WBGene00006576
• Length: 406
• Species: Caenorhabditis elegans
• Alignment Length: 460
• Identity: 83/460 - (18%)
• Similarity: 154/460 - (33%)
• Gaps: 167/460 - (36%)

  Fly    74 DELLTIAWVACIVFIIV---GVPGNLLTIVALSRGRQTRNSTAIFIINLSCSDLLFGCFNLPLAA 135
            :.|.|..:|| |.|:::   .:.||.:.:..:.:.:........|:.|::.:|||...||:..:.
 Worm    38 ESLATQVFVA-IAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFLFNMAFADLLIALFNVGTSW 101

  Fly   136 STFKERAWTHSDLLCRLFPMLRYGLLAVSLLSVSLITINRYIIIAHPRQ-YPRIYQRRYLALMVA 199
            :......|.:.| ||.|..........||:.|:..::.:|...:.:|.| .|...:|..:|:::
 Worm   102 TYNLYYDWWYGD-LCTLTSFFGIAPTTVSVCSMMALSWDRCQAVVNPLQKRPLSRKRSVIAILI- 164

  Fly   200 GTWITTFSIMIPTWRGVWGIFGLDVSIGSCSIMHDRYGRSPKEFLFIAAFMVPCICIVICYARIF 264
             .|:.:....:|        |.:..|:.|                            :..|..:.
 Worm   165 -IWVVSTVTALP--------FAIAASVNS----------------------------LYTYDVVT 192

  Fly   265 LLVRKAAIRAGTAGKTNVSDVTPSSAPQHQIQAMATPKKPEKVTTSSGEANEPIAGRPFVVEENL 329
            ..|.||.:               .|||.:...        |||.
 Worm   193 STVSKAHV---------------CSAPVNTFF--------EKVL--------------------- 213

  Fly   330 AYIDDNASTDSLPISYSIRRRDQDQQPPPVDANVVLKEREKERDRDQEKVSLGRSQTQLEMGKTH 394
                       ..|.|::          |:                   :.||.:.|:
 Worm   214 -----------FGIQYAL----------PI-------------------IILGSTFTR------- 231

  Fly   395 GKNPITTSLRTTSFTRFSPRKSHYASMGNTSNASSIYPGRMSAKDRRLLKMILVIFVWFVICYLP 459
                |..:.|.|                |.:..||:......||. :.:||:.::.|.||:|:||
 Worm   232 ----IAVAFRAT----------------NEATDSSLKNNHTRAKS-KAVKMLFLMVVAFVVCWLP 275

  Fly   460 ITVAKIWKSATEVHWFNIA----GYLLIY---LTTC-INPLIYVLMSSEYRRAYWNLLRCHGSPD 516
            .   .|:.:.....:|:.|    .|||||   :::| .||:||...:..:|..:..:.|.....|
 Worm   276 Y---HIYHAFALEEFFDAARGKYAYLLIYWIAMSSCAYNPIIYCFANERFRIGFRYVFRWIPVID 337

  Fly   517 TQKQR 521
            .:|::
 Worm   338 CKKEQ 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4313	NP_569971.3	7tmA_GPR84-like	78..505	CDD:320338	79/438 (18%)
		TM helix 1	79..105	CDD:320338	6/28 (21%)
		TM helix 2	112..135	CDD:320338	7/22 (32%)
		TM helix 3	150..180	CDD:320338	6/29 (21%)
		TM helix 4	194..212	CDD:320338	2/17 (12%)
		TM helix 5	237..262	CDD:320338	1/24 (4%)
		TM helix 6	437..467	CDD:320338	11/29 (38%)
		TM helix 7	473..498	CDD:320338	12/32 (38%)
tkr-1	NP_499064.2	7tm_GPCRs	44..326	CDD:475119	78/436 (18%)
		TM helix 1	46..70	CDD:320512	6/24 (25%)
		TM helix 2	79..101	CDD:320512	7/21 (33%)
		TM helix 3	116..138	CDD:320512	4/21 (19%)
		TM helix 4	160..176	CDD:320512	3/25 (12%)
		TM helix 5	207..230	CDD:320512	8/91 (9%)
		TM helix 6	259..281	CDD:320512	9/24 (38%)
		TM helix 7	294..319	CDD:320512	10/24 (42%)