Protein Alignment usp and nr2c1

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001016207.1
• Gene: nr2c1 / 548961
• XenbaseID: XB-GENE-484727
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 540
• Identity: 140/540 - (25%)
• Similarity: 230/540 - (42%)
• Gaps: 143/540 - (26%)

  Fly    54 LPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNH--PLSGSK-----------HLCS 105
            ||.....:..::|.|...:. .|::||.:.........|..|  .||.::           .||.
 Frog    90 LPSKVILTRQDSSQGKVYLT-TPDAAGVNQLFISTPDVPAQHIQILSDTQCLDQNLNKQLVELCV 153

  Fly   106 ICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMK 170
            :|||:|||:|||..:||||||||||::||:|.|.||.:::|:|:|..||||||||.|:|:..|||
 Frog   154 VCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYTCRGSKDCVINKHYRNRCQYCRLQRCIALGMK 218

  Fly   171 REAVQEER--------------------------------------------------------- 178
            :::||.||
 Frog   219 QDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATTTFVTENKTSRTTSLLDSGMLVNI 283

  Fly   179 -QRGARNAA-----GRLSASGGGSSGPGSVGGSSSQGGGGGG--------GVSGGMGSGNGS--- 226
             |.|.:|.:     .::.|..|..|...:|..|.:.......        .:...:.:|:.|
 Frog   284 QQSGVKNESILITPNKVDACQGDLSTLANVVTSLANLNKSKELPQTNTELSIIESLSNGDSSLSE 348

  Fly   227 ---DDFMTNSVSRDFS--IERIIEAEQRAE--TQC-------------------GDRALTFLRVG 265
               ||...:.|:|.|.  .:.:.::|..|:  ::|                   .|..:.|....
 Frog   349 LAQDDQSNSEVTRAFDTLAKALNQSENSAQGSSECVGSNSNLTDANVEIEGPLLSDAHIAFRLTM 413

  Fly   266 PYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVA-WC 329
            |  :..|:|.. |..:|:..::.||..:.:||.:|.|..:..::.:.|:||.|.||....:| .|
 Frog   414 P--SPMPEYLN-VHYICESASRLLFLSMHWARSIPSFQSLGQENSISLVKACWNELFSLGLAQCC 475

  Fly   330 SIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRI--LSE 392
            .:::::...|    ..:.|                 |:.|..:.:.||.|  |..:.|.|  |.|
 Frog   476 QVMNVETILA----AFVNH-----------------LHNSMQHDKLSADK--VKLVMDHIFKLQE 517

  Fly   393 LSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQ 457
            ....|.:|::|..|.:.||||.|::||..|:::.:.||..:||.|....::....:|.|..|.::
 Frog   518 FCNSMVKLSVDGYEYAYLKAIALFSPDHPGLENVSHIEKLQEKAYMEFQDYVTKTYPEDTYRLSR 582

  Fly   458 LLLRLPALRSISLKCQDHLF 477
            |||||||||.::....:.||
 Frog   583 LLLRLPALRLLNAAITEELF 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	45/75 (60%)
		NR_LBD_RXR_like	237..480	CDD:132741	68/267 (25%)
nr2c1	NP_001016207.1	NR_DBD_TR2_like	147..233	CDD:143525	47/85 (55%)
		NR_LBD_TR2_like	401..622	CDD:132750	64/228 (28%)