Protein Alignment usp and Nr1d2

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001412823.1
• Gene: Nr1d2 / 353187
• MGIID: 2449205
• Length: 586
• Species: Mus musculus
• Alignment Length: 614
• Identity: 152/614 - (24%)
• Similarity: 227/614 - (36%)
• Gaps: 204/614 - (33%)

  Fly    29 SNNSSFSPKA----ESPVPFMQAMSMVHVLPGSNSASSNNN------SAGD----AQMAQAPNSA 79
            |::|:.||.:    .|...|..:.|.|...|.|::..:|.|      |:.|    :.....|...
Mouse    14 SSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNCDANGNPKNADISSIDGVLKSDRTDCPVKT 78

  Fly    80 GGSAAAAVQQQY----------PPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRK 134
            |.::|..:.:.:          |.....||...||.:|||.|||.||||::||||||||:|::::
Mouse    79 GKTSAPGMTKSHSGMTTFYFLSPYALEFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQ 143

  Fly   135 DLTY-ACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAV------QEERQR------GARNAA 186
            ::.| .|.:|.||.|.:..|||||.||::|||:.||.|:||      :.|:||      .|....
Mouse   144 NIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTM 208

  Fly   187 GRLSASG-----------GGSSGP-----------------------------GSV--------- 202
            .....||           ..|:.|                             |.|
Mouse   209 MNTQFSGHLQNDTLAEQHDQSALPAQEQLRPKSQLEQENIKNTPSDFAKEEVIGMVTRAHKDTFL 273

  Fly   203 -------GGSSSQGGGGGGGVSGGM----------GSG--------------------------- 223
                   ..|.|.....|..:...|          |||
Mouse   274 YNQEHRENSSESMPPQRGERIPRNMEQYNLNQDHRGSGIHNHFPCSERQQHLSGQYKGRNIMHYP 338

  Fly   224 NGSDDFMTNSVSRDFS-------IERI-----IEAEQRAETQC--GDR--ALTFLRVGPYSTVQP 272
            ||....:.|....:||       .:||     .:.|.|....|  |.|  .:..:...||  |.|
Mouse   339 NGHAVCIANGHCMNFSSAYTQRVCDRIPVGGCSQTENRNSYLCNTGGRMHLVCPMSKSPY--VDP 401

  Fly   273 DYKG-------------AVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIA 324
            ...|             ||.           ::||:|:.:|.|..:...|||.||||...|:|:.
Mouse   402 QKSGHEIWEEFSMSFTPAVK-----------EVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMV 455

  Fly   325 NVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAG--VSAIFD 387
            ..|     ||.|              :.||....|.      .:.:|.....::.||  :|::|
Mouse   456 RFA-----SLFD--------------AKERTVTFLS------GKKYSVDDLHSMGAGDLLSSMF- 494

  Fly   388 RILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDD 452
                |.|.|:..|.|...|:|...|::|.:.|..||::...:|..:|.:...|.......||.:.
Mouse   495 ----EFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEA 555

  Fly   453 GRFAQLLLRLPALRSISLKCQDHLFLFRI 481
            ..|.:|||:||.|||::....:.|..|::
Mouse   556 SIFTKLLLKLPDLRSLNNMHSEELLAFKV 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	42/82 (51%)
		NR_LBD_RXR_like	237..480	CDD:132741	69/273 (25%)
Nr1d2	NP_001412823.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..256		2/30 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..292		2/18 (11%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	404..586		57/222 (26%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:29533925	1..60		12/45 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..90		17/75 (23%)