Protein Alignment usp and Nr2c2

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001334271.1
• Gene: Nr2c2 / 22026
• MGIID: 1352466
• Length: 629
• Species: Mus musculus
• Alignment Length: 611
• Identity: 157/611 - (25%)
• Similarity: 235/611 - (38%)
• Gaps: 214/611 - (35%)

  Fly    35 SPKAESPVPFMQAMSMVHVL--PGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHP- 96
            ||...||.|.:|.:|....:  |......::..:....|:..|.:::|.|     :||:....|
Mouse    31 SPGMTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSS-----KQQFILTSPD 90

  Fly    97 -------------LSGSKHL---------------------------------------CSICGD 109
                         .|.:|.|                                       |.:|||
Mouse    91 GAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGD 155

  Fly   110 RASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAV 174
            :|||:|||..|||||||||||:|||:|||:||.:::|||:|..|||||:||.:|||..|||.|:|
Mouse   156 KASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESV 220

  Fly   175 QEER-----QR----------------------------------GAR----------------- 183
            |.||     ||                                  |||
Mouse   221 QSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPL 285

  Fly   184 ---NAAGRLSASGGGSSGPGSVGG-----------SSSQGGGGGG-------------------- 214
               :....|:|.....:..|::|.           |.|...|...
Mouse   286 IREDGTVLLAADSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLA 350

  Fly   215 ------------GVSGGM-GSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGP 266
                        .::.|: .||.||    .:.:|||.|.. |||.|   .....|..:||....|
Mouse   351 KALNTTDSASPPSLADGIDASGGGS----IHVISRDQSTP-IIEVE---GPLLSDTHVTFKLTMP 407

  Fly   267 YSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCS- 330
              :..|:|.. |..:|:..::.||..:.:||.:|.|..:..|....|::|.|.||....:|.|:
Mouse   408 --SPMPEYLN-VHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQ 469

  Fly   331 IVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRI------ 389
            ::||                            ...|....::.:||..:..:|.  |||
Mouse   470 VMSL----------------------------STILAAIVNHLQNSIQEDKLSG--DRIKQVMEH 504

  Fly   390 ---LSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGD 451
               |.|....|.:|::|..|.:.||||:|::||..|:...::||..:||....|.::.:..:..|
Mouse   505 IWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSED 569

  Fly   452 DGRFAQLLLRLPALRSISLKCQDHLF 477
            ..|.|::|:||||||.:|....:.||
Mouse   570 TYRLARILVRLPALRLMSSNITEELF 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	50/114 (44%)
		NR_LBD_RXR_like	237..480	CDD:132741	69/251 (27%)
Nr2c2	NP_001334271.1	NR_DBD_TR2_like	145..231	CDD:143525	51/85 (60%)
		NR_LBD_TR2_like	394..615	CDD:132750	63/235 (27%)