Protein Alignment usp and Nr2c1

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_035759.3
• Gene: Nr2c1 / 22025
• MGIID: 1352465
• Length: 590
• Species: Mus musculus
• Alignment Length: 504
• Identity: 134/504 - (26%)
• Similarity: 214/504 - (42%)
• Gaps: 132/504 - (26%)

  Fly   103 LCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTC 167
            ||.:|||:|||:|||..:||||||||||::||:|.|:||.:::|:|:|..||||||||.|:|:..
Mouse   100 LCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCVINKHHRNRCQYCRLQRCIAF 164

  Fly   168 GMKREAVQEER----------------------QRGARN----------------AAGRLSA--- 191
            |||:::||.||                      ::..|:                :||.|.:
Mouse   165 GMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSAGLLDSGMF 229

  Fly   192 -----SG------------------GGSSGPGSVGGSSSQGG--------GGGGGVSGGMGSGNG 225
                 ||                  |..|...||..|.:..|        ||...|...:.:|:.
Mouse   230 VNIHPSGIKTEPAMLMAPDKAESCQGDLSTLASVVTSLANLGKAKDLSHCGGDMPVVQSLRNGDT 294

  Fly   226 S-----DDFMTN-SVSRDF-SIERIIEAEQRAETQCGDRAL---TFLRVGPYSTVQ--------- 271
            |     .|..|| .|||.| ::.:.:...:.:..|..:..:   ..|..|..|.|:
Mouse   295 SFGAFHHDIQTNGDVSRAFDTLAKALTPGESSACQSPEEGMEGSPHLIAGEPSFVEKEGPLLSES 359

  Fly   272 ------------PDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIA 324
                        |:|.. |..:.:..::.||..:.:|..:|.|..:..::.:.|:||.|.||...
Mouse   360 HVAFRLTMPSPMPEYLN-VHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTL 423

  Fly   325 NVAWC----SIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAI 385
            .:|.|    ::.::...........|..|.....|...|. :.:|..|.|.   ||.:|
Mouse   424 GLAQCWQVMNVATILATFVNCLHSSLQQDKMSPERRKSLM-EHIFKLQEFC---NSMVK------ 478

  Fly   386 FDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPG 450
                          |.:|..|.:.||||:|::||..|:::...||..:||.|....::....:|.
Mouse   479 --------------LCIDGHEYAYLKAIVLFSPDHPGLENMELIERFQEKAYVEFQDYITRTYPD 529

  Fly   451 DDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQLEAPP 499
            |..|.::|||||||||.::....:.||...:..:..::.:....|:..|
Mouse   530 DTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHILKMEP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	45/74 (61%)
		NR_LBD_RXR_like	237..480	CDD:132741	62/271 (23%)
Nr2c1	NP_035759.3	Required for interaction with KAT2B	1..166		40/65 (62%)
		NR_DBD_TR2_like	96..182	CDD:143525	47/81 (58%)
		NR_LBD_TR2_like	355..576	CDD:132750	57/245 (23%)
		Required for interaction with NRIP1	571..590		2/8 (25%)