Protein Alignment usp and nhr-119

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_494368.2
• Gene: nhr-119 / 187340
• WormBaseID: WBGene00003709
• Length: 708
• Species: Caenorhabditis elegans
• Alignment Length: 486
• Identity: 118/486 - (24%)
• Similarity: 209/486 - (43%)
• Gaps: 117/486 - (24%)

  Fly    72 MAQAPNSAGGSAAAAVQQQYP----PNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTV 132
            |.:...|:..:.||::.::..    .:|  ||....|.:|||..:..||||.:|.||||||:||:
 Worm     1 MGKVDTSSLENMAASISRKSSLSQIASH--SGGSDTCKVCGDGNAKTHYGVVTCFGCKGFFRRTL 63

  Fly   133 RKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSS 197
            ::...|.||.|.:|::|:.:||.|::||::||:..||..:||:.:|....|:..||...|...:.
 Worm    64 KRPSEYTCRHNGHCVVDRHERNSCRFCRFKKCIEVGMDPKAVRPDRDATGRHYQGRQRRSKLSAE 128

  Fly   198 GPGSVGGSSSQ--------------------GGGGGGGVSGGMGSGNGSDDFMTNSVSRDF---- 238
            ..|.|.....:                    |||.|                 ....|:.:
 Worm   129 DEGEVDAEWMRKLPVDMRTTLMQLLNIDLIVGGGDG-----------------HTEPSKIYPLPF 176

  Fly   239 --SIERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPH 301
              ||.:::|     :....|...|.:|...:..:.||      .|..:.:::|..|:::|..:..
 Worm   177 ATSIRQLLE-----DPTLLDGKRTEMRYETFREINPD------ELPCIAHRRLIAMIDWADHLFD 230

  Fly   302 FAQV-PLDDQVILLKAAWIELLI----ANVA---WCSIVSLDDGGAGGGGGGLGHDGSFERRSPG 358
            ...| .:||::.::||::..|:|    ||.:   ...||.|..            .|...|.:|.
 Worm   231 MMDVNNMDDKIAIVKASYGPLMIFSLCANTSRHKMSDIVCLST------------FGYISRYAPN 283

  Fly   359 --LQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIR 421
              .:|          ||..:.:.       :|.:.||...:|::||...|::.:||||:.||.::
 Worm   284 GWAEP----------YHFGNQLA-------ERCIDELIDPLKKMNLKEEEITLIKAIIVLNPYLK 331

  Fly   422 GIK---SRAEIEMCREKVYACLDEHCRLEHPGD--DGRFAQLLLRLPALRSISLKCQDHLFL--- 478
            .:.   |.|.::: |:::...|....|..||.:  ..||..|||.:|::..:.....::|..
 Worm   332 TLTQDGSEAIMDL-RDRIQETLYHVVRETHPKEVASSRFGNLLLFVPSVMMLGRLVTENLSFVDS 395

  Fly   479 FRITSDRPLEELF-----LEQLEAP----PP 500
            |...:|..:.:|.     :||..:|    ||
 Worm   396 FGQMNDALVHDLLQEAPKVEQNRSPTNTSPP 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	34/75 (45%)
		NR_LBD_RXR_like	237..480	CDD:132741	57/266 (21%)
nhr-119	NP_494368.2	NR_DBD_HNF4A	35..110	CDD:143518	34/74 (46%)
		HOLI	214..380	CDD:214658	47/195 (24%)