Protein Alignment usp and nhr-120

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_509116.2
• Gene: nhr-120 / 182882
• WormBaseID: WBGene00003710
• Length: 477
• Species: Caenorhabditis elegans
• Alignment Length: 549
• Identity: 114/549 - (20%)
• Similarity: 195/549 - (35%)
• Gaps: 171/549 - (31%)

  Fly     3 NCDQ-DASFRLSHIKEEVKPDISQLN--DSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNN 64
            ||.. |.|.:|.|....:..:...:|  |.:.||.||.:                  |:|.|...
 Worm     9 NCTHLDKSNKLLHPSPPMWINRDSMNWVDGSLSSHSPMS------------------SDSISPLR 55

  Fly    65 NSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPL-------SGSKHLCSICGDRASGKHYGVYSCE 122
            :.|.|..|.:..::           :..|..|:       ...||.||:||||.:|.||.|.||.
 Worm    56 SPAEDTNMVECSSN-----------ELQPPAPIRKIRNVRKSDKHHCSVCGDRPTGYHYDVLSCN 109

  Fly   123 GCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAG 187
            |||.||:||:.....:.|.:..||...|..|..|:.||::||:..||...|:|
 Worm   110 GCKTFFRRTIINSRNFICTKGGNCQFTKDFRCACRACRFEKCVRVGMNPSAIQ------------ 162

  Fly   188 RLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAET 252
                            ..||:.......:..|....|..||       :..::...:.|..|..|
 Worm   163 ----------------FPSSKNHNEADDMDSGDEDSNIQDD-------KSLALIPFVSAPLRETT 204

  Fly   253 -----------QCGDRALTFLRVGPYSTVQPDY--------KGAVSALCQVVNK----------- 287
                       :..|..|.. |:.....|:.|:        ...:...|.:..|
 Worm   205 IHTYRWVDDIFRREDAVLRH-RIPGTLPVEDDFCLGELLRKNILIGGDCAIDRKPGTLYTNDPVR 268

  Fly   288 -----QLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAW-------CSIVSLDDGGAG 340
                 .|..:||:|:....|.::...||..|:......|.:|..::       .|.::..||
 Worm   269 YWMVVDLLLIVEFAKTFESFRKLSEFDQKCLISHIGGVLHVATQSFYSYFEAKSSTLTFPDG--- 330

  Fly   341 GGGGGLGHDGSFERRSPGLQ------PQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKR 399
                    ..:|||:...::      .:::|||    |:         :.:::..::|. :|.|
 Worm   331 --------INAFERKMADVEKDDKRRSRKVFLN----YY---------AEMYNAPVNEF-LKNK- 372

  Fly   400 LNLDRRELSCLKAIILYNPDIRGIKSRAEIEMC----------REKVYACLDEHCRLEHPGDDG- 453
              :...|.|..|:|.|::||        .:||.          ||::...|.::...|:....|
 Worm   373 --VTMTEYSFFKSISLFSPD--------NLEMSDAGRLIANEERERLTTLLRKYLVAEYGFKVGM 427

  Fly   454 -RFAQLLLRLPALRSISLKCQDHLFLFRI 481
             ||:.:|:.:....:...|.:|::.|..:
 Worm   428 NRFSLILMAISTFVNYGEKRRDYISLMSL 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	34/75 (45%)
		NR_LBD_RXR_like	237..480	CDD:132741	53/302 (18%)
nhr-120	NP_509116.2	NR_DBD_HNF4A	91..164	CDD:143518	33/100 (33%)
		NR_LBD	267..440	CDD:132726	40/208 (19%)