Protein Alignment usp and nhr-14

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_741860.2
• Gene: nhr-14 / 181102
• WormBaseID: WBGene00003613
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 422
• Identity: 135/422 - (31%)
• Similarity: 190/422 - (45%)
• Gaps: 86/422 - (20%)

  Fly    98 SGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQ 162
            |.|...|.:|||:|.|||||..:|.||||||:|:|.::|.|.||.|:.|.|||..||.|:|||:|
 Worm    14 STSADFCVVCGDKAIGKHYGAVACNGCKGFFRRSVWQNLQYTCRFNKQCNIDKDHRNACRYCRFQ 78

  Fly   163 KCLTCGMKREAVQEERQR-GARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGS 226
            |||..|||.||:|.||.| |:.....|        ||..|...|.|:            |:.:..
 Worm    79 KCLADGMKPEAIQNERDRIGSTKRRKR--------SGANSENNSDSE------------GTPSPK 123

  Fly   227 DDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQ 291
            .:.|.|||||.. ||.:::.|.|..:.....||  ||         |.....::..:.||    .
 Worm   124 IEVMGNSVSRKL-IEMLLDIEHRLASNQSMNAL--LR---------DESEMKNSRQRAVN----Y 172

  Fly   292 MVEYARMMPHFAQVPLDDQVILLK--AAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFER 354
            ::.:..|:....:|||.|:|:|||  ::...||                     |.|       :
 Worm   173 LIGWTNMLHPLPEVPLADKVLLLKKFSSAFTLL---------------------GTL-------Q 209

  Fly   355 RSPGLQ----PQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIIL 415
            ||..|.    |....|:.|.| |.....:|     ..||:.||...::||..|..|.|||||::|
 Worm   210 RSMALPHFVLPNDQVLSISAS-HPPELFEA-----LTRIIDELLTPLRRLRTDHAEFSCLKALLL 268

  Fly   416 YNPDIRGI--KSRAEIEMCREKVYACLDEHCRLEHPGDDG--RFAQLLLRLPALRSISLKCQDHL 476
            .|||:.||  .:|..|...|:.:...|..:........|.  |.:.||:.:|:|.|:|....:..
 Worm   269 LNPDVVGISNNTRERIREARDALLKTLFAYMSNTQNSIDASLRVSSLLMIIPSLISVSSSIMEFP 333

  Fly   477 FLFRI--TSDRPLEELFLEQLEAPPPPGLAMK 506
            .|..:  ..|....:....::|.||   |.||
 Worm   334 ALSDLFGLGDVIKRDTISPKIETPP---LEMK 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	44/75 (59%)
		NR_LBD_RXR_like	237..480	CDD:132741	65/252 (26%)
nhr-14	NP_741860.2	NR_DBD_HNF4A	20..95	CDD:143518	45/74 (61%)
		HOLI	176..322	CDD:214658	50/179 (28%)